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Pharma Tech Trends and Development Cost Solutions

Published: Thursday, April 04, 2013
Last Updated: Thursday, April 04, 2013
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METTLER TOLEDO’s new on-demand webinar, “Methods to Improve Chemical Process Development,” takes on the challenges of today’s pharmaceutical market.

The free webinar lays out the pressures currently being faced by the industry—including cost and regulatory pressures—and explores the chemistry workflows and emerging technologies that are helping industry participants address these challenges, remain competitive, and protect profits.

With the reality of patent cliffs, regulatory standards, attrition, and globalization, companies are learning to work fast and “lean” without sacrificing effectiveness and safety. In the webinar, targeted technology application and the methodologies it enables results in an ability to handle increased experiment volume—the kind that will be required for success if pharmaceutical industry trends continue—while lowering development and production costs.

Accounting for issues such as inherited chemistry, variable yields, and long development cycles, the webinar looks at real-world examples of industry giants such as Pfizer using technologies that help understand particle and reaction characteristics for significant process enhancement. In situ mid-IR spectroscopy and Focus Beam Reflectance Measurement (FBRM®)—as well as workstations that incorporate them—are shown to illuminate particle growth/crystallization and other critical reaction characteristics to shorten cycle times, increase yields, enhance safety, and ease scale-up. One production initiation example lowered costs by at least $.5M—a savings that will compound with each successive use of the equipment.

Reaction Progress Kinetics Analysis is also discussed in detail. This methodology, developed by Professor Donna Blackmond who is currently with Scripps Research Institute, allowed researchers to develop a kinetic model in significantly fewer experiments over traditional methods, which in turn helped optimize a synthetic route for enhanced commercial viability.


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