Corporate Banner
Satellite Banner
Medicinal Chemistry
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Labcyte Announces Collaboration with AstraZeneca

Published: Wednesday, September 25, 2013
Last Updated: Wednesday, September 25, 2013
Bookmark and Share
Companies collaborate to use acoustic dispensing combined with mass spectrometry to greatly advance drug discovery applications.

Labcyte, who developed and commercialized acoustic liquid handling, recently developed techniques for the direct loading of samples into mass spectrometers. This capability creates the potential for high throughput, low cost, label-free analysis. AstraZeneca is supporting this development effort with the goal of expanding mass spectrometry-based analysis throughout the entire drug discovery and development process.

Mass spectrometry is used to quantify the amount of drug substance in screening assays, drug metabolism studies, and safety and efficacy experiments. The Labcyte Echo® acoustic liquid handling system uses sound waves to dispense a wide variety of liquids in nanoliter increments.
The development of an instrument that enables the delivery of test samples into a mass spectrometer through acoustic dispensing will generate better results with lower costs compared to traditional systems, which can be prone to transfer errors and sample contamination. It will streamline the process required to carry out these activities while increasing capacity to enable use in screening.

The drug discovery process requires continued advancement to generate greater biologically relevant data at lower costs and faster throughput. Data rich, label-free assays and broader phenotypic analyses are viewed as critical requirements to the future success of drug discovery programs. This trend requires novel techniques to meet these challenges. Mass spectrometry is an ideal candidate from a data perspective, but current throughput and cost per data point prevent the technology from being fully exploited. The goal of this collaboration is to overcome these limitations by enabling analysis of samples transferred directly from standard microplates with throughput significantly higher than current commercially available systems with substantially lower cost per data point.

“The potential for this breakthrough is yet another example of the incredible impact that acoustic dispensing is having in all areas of life sciences,” said Mark Fischer-Colbrie, Labcyte president and CEO. “Customers, including AstraZeneca, are using our acoustic liquid handling systems to discover new therapeutics, generate better diagnostic results or achieve personalized medical treatments. This work with AstraZeneca has the possibility to achieve dramatic improvements in measuring samples and experimental results. We are very excited to be working with one of the world’s leading pharmaceutical companies to pursue this major opportunity. It is a further testament to the unique capabilities of acoustic liquid handling.”

“The potential benefits of combining these technologies were originally identified by two of our Scientists,” said Mike Snowden, AstraZeneca VP Discovery Sciences. “We are excited to be working with Labcyte to develop acoustic dispensing for mass spectrometry. This project forms part of AstraZeneca’s efforts to access world-leading innovation to enhance the success of drug discovery. Combining acoustic delivery with mass spectrometry has the potential to open up new areas of science through transformational improvements in sampling rates and reductions in sampling volumes.”


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,200+ scientific posters on ePosters
  • More than 4,800+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Labcyte Echo Acoustic Liquid Handler an Essential Component of Pharmaceutical High-Throughput Screening
Recent issue of JBS emphasizes the importance of acoustic liquid handling in drug discovery.
Friday, August 07, 2009
Labcyte Receives 22nd Patent for Restoration of Fluid Volume and Composition Using Acoustics
Patent discloses how to use acoustics to monitor the composition and volume of a fluid and maintain those parameters via active fluid supplementation.
Monday, September 05, 2005
Scientific News
Accessing Metabolic Information with Mass Spec
Scientists at the Helmholtz Zentrum München have developed a new mass spectrometry imaging method which, for the first time, makes it possible to analyze hundreds of metabolites in fixed tissue samples.
Simplifying Gene Testing Access for Ovarian Cancer Patients
Simplifying access to gene testing for women with ovarian cancer improves treatment choices and could save lives.
New Protein Model Could Accelerate Drug Development
Stony Brook-led international research team creates ultra-fast approach to model protein interactions.
New Method Opens Door to Development of Many New Medicines
Findings from TSRI reveal human proteins are better drug targets than previously thought.
What Makes a Good Scientist?
It’s the journey, not just the destination that counts as a scientist when conducting research.
Angina Drug Could Inform A New Strategy To Fight Cryptococcosis
A drug, more commonly used in the treatment of angina, could be the focus of a new strategy in fighting the fatal fungal infection cryptococcosis.
New Skin Cancer Drugs with Surprising Powers
Inserm team synthesizes and developed new drugs for melanoma.
Breast Cancer Drug Hope
A drug for breast cancer that is more effective than existing medicines may be a step closer thanks to new research.
Benchtop Automation Trends
Gain a better understanding of current interest in and future deployment of benchtop automated systems.
A New Platform for Discovering Antibiotics
Harvard chemists hope to shorten time, difficulty in measuring their effectiveness, potential.
SELECTBIO

SELECTBIO Market Reports
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,200+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,800+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!