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Mettler-Toledo Presents Live Webinar on Ensuring USP Compliance

Published: Friday, November 29, 2013
Last Updated: Thursday, November 28, 2013
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Mr. Gregory Martin will explain the implications of the latest USP revisions for balance users.

Mettler-Toledo has announced an upcoming webinar entitled “Ensuring USP Compliance with Revised Chapters on Weighing" with special guest presenter Mr. Gregory Martin, President of Complectors Consulting LLC.

The United States Pharmacopeia (USP) revisions to General Chapters <41> Balances and <1251> Weighing on an Analytical Balance will become official on December 1, 2013.

This webinar will be hosted on Dec 3, 2013 at 08:00 PST, 11:00 EST, 16:00 GMT; 17:00 CET. Event registration is at:

In this free educational webinar, laboratory managers and professionals who are concerned with regulatory affairs, compliance and metrology will learn about the details of these latest changes, understand the impact on their weighing processes and gain advice on how to update their standard operating procedures (SOP's) to remain compliant.

General Chapter <41> now states that accurate weighing must be performed using a calibrated balance. Repeatability and accuracy requirements are clarified and updated, with new acceptance limits and permissible test weights.

General Chapter <1251> has undergone major revisions focusing on balance qualification and operation, including the importance of "minimum weight". A daily balance check, typical in the pharmaceutical industry, is not actually a requirement. Instead, the type and frequency of balance checks should be determined by the risk and process tolerance of the application. Performing the right tests at the right intervals will ensure quality results and can potentially save time and money by eliminating unnecessary testing!

General Chapter <1251> also introduces "gravimetric dosing", a weighing methodology for analytical standard and sample preparation. This method involves weighing of the sample and diluent, resulting in concentration units of mg/g.

During this webinar, Mr. Gregory Martin will explain the implications of the latest USP revisions for balance users. Weighing and compliance experts from Mettler-Toledo will advise on how standard operating procedures (SOP's) should be updated to ensure compliance.

This webinar provides a unique opportunity to obtain expert advice during a live question and answer session after the presentation, allowing verification that individual weighing processes are up-to-date in advance of the next audit.

The key learning objectives for webinar attendees are: to discover which tests have to be periodically performed on balances used for quantitative analysis and which acceptance criteria apply from 1st Dec, based on the USP revisions; to recognize that a daily balance check is not a requirement and get insight into the risk-based approach recommended by USP General Chapter <1251>; to learn how to assess and calculate the minimum weight of a balance; and to find out more about gravimetric sample preparation and how to implement this method.

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