Corporate Banner
Satellite Banner
Medicinal Chemistry
Scientific Community
Become a Member | Sign in
Home>News>This Article

Argenta, Antabio Achieve Milestone in Anti-bacterial Drug Discovery Collaboration

Published: Monday, March 10, 2014
Last Updated: Monday, March 10, 2014
Bookmark and Share
Argenta has achieved a milestone with its collaboration partner Antabio in an anti-bacterial drug discovery project funded by the Wellcome Trust.

The attainment of the milestone triggers the drawdown of a further €1.7 million tranche of their Seeding Drug Discovery Award.

A novel lead series of pan-metallo beta-lactamase inhibitors has been identified that, in combination with carbapenems, restores antibacterial activity against life-threatening clinical isolates whilst exhibiting no toxicity or developmental issues. Multi-drug resistant Gram-negative bacteria account for most hospital infections worldwide, causing up to 75,000 deaths yearly and extra healthcare costs/productivity losses of >€1.5 billion. One of the most effective treatments is the use of carbapenem antibiotics; however, the usefulness of these antibiotics is becoming increasingly compromised due to the rise of clinical resistance, associated with the spread of genes encoding various MBL enzymes, primarily the carbapenemases of the NDM, VIM and IMP types. 

The Argenta/Antabio collaboration began in February 2013, when the Wellcome Trust awarded Antabio €4.7 Million to fund the discovery of a novel, safe and efficacious pan-inhibitor of bacterial metallo beta-lactamases (MBLs). Since then, Argenta has provided medicinal chemistry, computer-aided drug design and ADME/PK services, together with its integrated drug discovery expertise, to assist Antabio achieve its research goals.

“To have achieved on schedule our first milestone in our collaboration with the Trust is a great satisfaction for our team, and a sign that solid foundations are in place for this discovery programme.” said Marc Lemonnier, CEO of Antabio. “We believe the therapeutic potential of a small-molecule pan-MBL inhibitor is very significant and will eventually improve the outcome for patients suffering from severe nosocomial Gram-negative infections. This milestone will support further lead optimization efforts to progress our compounds rapidly towards pre-clinical candidate nomination.”

John Montana, Argenta’s Managing Director, added “We are delighted to have achieved this milestone with our collaboration partner, Antabio, and look forward to our continuing partnership on this exciting drug discovery project. Once again, this achievement underlines Argenta’s ability to deliver high quality science within exacting deadlines.”

Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,800+ scientific posters on ePosters
  • More than 4,000+ scientific videos on LabTube
  • 35 community eNewsletters

Sign In

Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Argenta Announces Record Year for Peer-Reviewed Publications
Publications have been co-authored with clients such as Genentech, AstraZeneca and Corcept.
Tuesday, December 10, 2013
Argenta Announces Fourth Extension of Drug Discovery Collaboration with Genentech
Agreement covers a portfolio of projects that utilizes Argenta's drug discovery expertise.
Monday, October 14, 2013
Argenta and Pcovery Announce Drug Discovery Collaboration
Under the terms of the agreement, Argenta will provide medicinal chemistry and computer-aided drug design services to assist Pcovery.
Tuesday, July 16, 2013
Argenta and ANTABIO Announce Drug Discovery Collaboration
Programme will focus on novel antibacterial agents.
Friday, February 08, 2013
Argenta Delivers Preclinical Candidate for Wellcome Trust Funded Anti-Aging Project
The three-year project aimed at identifying selective inhibitors of the 11beta-HSD1 enzyme resulted in the identification of a lead candidate.
Tuesday, October 19, 2010
Argenta Expands Collaboration with Genentech to Include BioFocus
Under the amendment, BioFocus will provide Genentech with integrated medicinal chemistry, in vitro biology and ADME services.
Thursday, September 16, 2010
Argenta Discovery Announces Two-Year Extension of Major Drug Discovery Collaboration with Genentech
This is the second extension of the contract drug discovery agreement since the first collaboration was announced in December 2005.
Friday, May 22, 2009
Argenta Discovery and Porsolt Join Forces to Provide CNS and Pain Contract Drug Discovery Services
The collaboration enables Argenta and Porsolt to undertake fully integrated CNS and pain-focused drug discovery programmes for clients.
Wednesday, May 20, 2009
Argenta Discovery and PRECOS Establish Cancer Drug Discovery Alliance
The alliance will provide exceptional cancer drug discovery services and expertise on a fee-for-service basis.
Thursday, February 19, 2009
Argenta Discovery Announces the Initiation of a Phase II Clinical Trial with ADC4022
The Phase II study is a multi-centre, randomized, double-blind, placebo-controlled study to evaluate the effect of inhaled ADC4022.
Monday, March 10, 2008
Argenta Discovery Announces Two-Year Extension of Major Drug Discovery Collaboration with Genentech
The two programmes under the agreement utilize Argenta's expertise to discover new chemical entities acting against undisclosed drug targets defined by Genentech.
Wednesday, October 24, 2007
Argenta Discovery Announces Contract Drug Discovery Collaboration with BioTie Therapies
Scientists from the two companies will exploit Argenta’s expertise in medicinal chemistry, computer-aided drug design and early ADME to advance one of BioTie’s therapeutics programmes.
Friday, April 06, 2007
Argenta Announces Collaboration with PainCeptor
Scientists from the two companies will exploit Argenta’s expertise in computer-aided drug design and medicinal chemistry.
Monday, May 01, 2006
Argenta Discovery collaboration with Corcept Therapeutics

Wednesday, May 07, 2003
Scientific News
Drug May Prevent Life-Threatening Muscle Loss in Advanced Cancers
New data describes how an experimental drug can stop life-threatening muscle wasting (cachexia) associated with advanced cancers and restore muscle health.
Chemical Design Made Easier
Rice University scientists prepare elusive organocatalysts for drug and fine chemical synthesis.
Nanocarriers May Carry New Hope for Brain Cancer Therapy
Berkeley lab researchers develop nanoparticles that can carry therapeutics across the brain blood barrier.
Potential Persistent Tuberculosis Treatment
Researchers have discovered several first-in-class compounds that target hidden TB infections by attacking a critical process the bacteria use to survive in the hostile environment of the lungs.
Shedding Light on “Dark” Cellular Receptors
UNC and UCSF labs create a new research tool to find homes for two orphan cell-surface receptors, a crucial step toward finding better therapeutics and causes of drug side effects.
Giant Molecules Inhibit Ebola Infection
European researchers have designed a "giant" molecule formed by thirteen fullerenes covered by carbohydrates which, by blocking this receptor, are able to inhibit the cell infection by an artificial ebola virus model.
First Therapy Appearing to Reverse Decline in Parkinson’s
An FDA-approved drug for leukemia improved cognition, motor skills and non-motor function in patients with Parkinson’s disease and Lewy body dementia in a small clinical trial, say researchers at Georgetown University Medical Center (GUMC).
Fighting Pain with Ketamine
Researchers at the Texas A&M Health Science Center are using ketamine, a drug that already exists as an anesthetic, to treat pain.
Possible New Treatment for Neurodegenerative Diseases Found
Researchers at the University of Liverpool have found that a well-established anti-epileptic drug could also be used as a treatment for neurodegenerative diseases.
Breast Cancer Drug Beats Superbug
Tamoxifen helps white blood cells clear multidrug-resistant bacteria in lab and mouse studies.
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,800+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,000+ scientific videos