Corporate Banner
Satellite Banner
Medicinal Chemistry
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Shimadzu Introduces C2P Automated Purification/Powderization System

Published: Thursday, May 15, 2014
Last Updated: Thursday, May 15, 2014
Bookmark and Share
Crude2Pure for improved purity, efficiency and productivity.

The field of drug discovery and research has long been complicated by lengthy process times and inefficient operations. Shimadzu Scientific Instruments (SSI) now offers Crude2Pure (C2P), the world’s first automated purification/powderization technology that eliminates time-consuming operations and allows researchers to focus on the crucial tasks of synthesizing and isolating target compounds.

Based on enhanced purification methods, C2P is designed for use with preparative liquid chromatography. The advanced system uses trap concentration to purify target compounds from synthetic products consisting of low molecular weight organic compounds and complicated natural substances, and recovers them as highly pure powders.

This innovative technology allows large-scale, multi-sample processing and will simplify operations, reduce operator workload, and improve productivity in a wide variety of fields, including drug manufacturing, food science, chemistry, government and academic research.

“We are pleased to offer this new technology to greatly enhance research and development projects that require high-quality purification of synthesized target compounds,” said Terry Adams, VP marketing, Shimadzu Scientific Instruments. “This system allows scientists and researchers to more efficiently perform this process, saving time and money for labs, academic institutions and drug developers.”

C2P is the first automated system in the world to accomplish purification of target compounds with high purity and free base resulting in powderized form. The system uses the newly developed Shim-pack C2P-H trapping column to retain target compounds and easily remove only residual components by rinse washing to purify the sample.

Target compounds are recovered “as-is” or as a free base, significantly improving the throughput of biochemical screening and absorption, distribution, metabolism and excretion testing in drug discovery and research.

The system accelerates the sample concentration and powderization process by directly eluting the target compounds retained in the trapping column through a spray nebulizer.

Conventional systems, which employ evaporation to dryness processes, can take as long as 24 hours to complete the process. With C2P, operators can complete the entire process in less than five hours. The system also prevents splashing and contamination problems that occur with conventional processes.

Shimadzu also offers Open Solution Crude2Pure Software, a user-friendly, convenient application that allows operators to set the trap/concentration and powderization operation in three steps. Compatible with an open-access environment, the system allows multiple researchers to share C2P equipment and provides email status notifications to off-site users.


Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,500+ scientific posters on ePosters
  • More than 3,700+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.


Scientific News
Toxin from Salmonid Fish has Potential to Treat Cancer
Researchers from the University of Freiburg decode molecular mechanism of fish pathogen.
New Diabetes Drug has Unexpected Side Effect
A type of drug used to treat diabetes may reduce the risk of developing Parkinson’s disease, according to new research.
Researchers Develop Vaccine that Protects Primates Against Ebola
A collaborative team from The University of Texas Medical Branch at Galveston and the National Institutes of Health have developed an inhalable vaccine that protects primates against Ebola.
Cannabis May Be Used to Treat Fractures
TAU researcher finds non-psychotropic compound in marijuana can help heal bone fissures.
A Novel Drug to FIght Malaria
An international team of scientists has announced that a new compound to fight malaria is ready for human trials.
New Cell Structure Finding Might Lead to Novel Cancer Therapies
University of Warwick scientists in the U.K. say they have discovered a cell structure which could help researchers understand why some cancers develop.
Creating More Potent Vaccines
Yale researchers uncovered a new role for a type of immune cell, known as regulatory T cells, in promoting long-term immunity.
Potential Therapeutic for Blinding Eye Disease
NIH research points to microglia as potential therapeutic target in retinitis pigmentosa.
Potential New Class of Cancer Drugs
Scientists have found a way to stop cancer cell growth by targeting the Warburg Effect, a trait of cancer cell metabolism that scientists have been eager to exploit.
Global Search for Next Antibiotic
University of Queensland researchers have launched a global search to discover antibiotics capable of combating superbug bacteria that are resistant to current antibiotics.
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,500+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
3,700+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FREE!