Corporate Banner
Satellite Banner
Medicinal Chemistry
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

New Screening Library Offers Exceptional Chemical Diversity to Increase Hit Probability

Published: Thursday, June 12, 2014
Last Updated: Thursday, June 12, 2014
Bookmark and Share
Delivering highly diverse coverage of drug-like chemical space in a single library.

A new highly diverse library of screening compounds is designed to maximize efficiency and productivity for researchers in early phase small molecule drug discovery.

By delivering exceptionally diverse coverage of the space spanned by all possible drug-like molecules and associated characteristics, the Maybridge HitCreator library provides a greater hit probability than larger, but less diverse, screening libraries.

The Maybridge HitCreator library consists of 14,000 screening compounds selected for maximum diversity by rigorous analysis of more than 500,000 commercially available screening compounds.

Each Maybridge HitCreator diversity library is conveniently available off the shelf and supplied as dry films in Thermo Scientific Matrix 96 shallow-well plates or 384-well microplates.

“Diversity-based screening is a vital tool for discovering new molecules that could potentially influence drug discovery. However, the wide range of commercially available screening libraries is daunting for scientists to pick the ideal library for their specific requirements,” said Simon Pearce, product marketing manager, Global Chemicals, Thermo Fisher Scientific. “Our new Maybridge HitCreator library simplifies this challenge through its exceptional diversity. It removed the need to choose between different libraries and covers all drug-like chemical space to provide cost effective hit reliability from a single library.”

Building on more than 50 years in designing proven libraries, all compounds within the Maybridge HitCreator are meticulously selected for a high hit probability. All are drug-like and conform to Lipinski’s “Rule of Five”, ensuring they possess key physicochemical properties frequently found in orally active drugs, as well as additional filters.

These include optimization to ensure a drug can readily permeate cells, therefore HitCreator compounds are selected to have a Polar Surface Area (PSA) of ≤ 140Å2. In addition, all compounds have been screened to remove inappropriate chemical structures, reducing the chance of “false hits.


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,000+ scientific posters on ePosters
  • More than 4,500+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Thermo Completes Sale of Cole-Parmer to GTCR
Thermo Fisher Scientific Inc. announced that it has completed the sale of its Cole-Parmer customer channel business to private equity firm GTCR LLC for approximately $480 million in cash.
Wednesday, August 20, 2014
Thermo to Sell Cole-Parmer for $480M
Company has signed a definitive agreement to sell its Cole-Parmer channel business to private equity firm GTCR, LLC for $480 million in cash.
Monday, July 21, 2014
Thermo Scientific Selected to Supply Maybridge Fragment Library for Key Research
Recommended for use by renowned fragment library design expert.
Tuesday, February 05, 2013
Record Revenues for Thermo Fisher Scientific
Revenue for the quarter grew 6% to $3.26 billion in 2012, versus $3.09 billion in 2011.
Thursday, January 31, 2013
Thermo Scientific Announces New UHPLC/MS Method for Trace-Level Analysis of Perfluorinated Compounds in Human Breast Milk
The method utilizes SRM and H-SRM on an integrated UHPLC/MS platform enables robust detection of PFCs at ppt concentrations.
Friday, August 27, 2010
Thermo Fisher Scientific Names Recipients of In Vitro Protein Expression Grants
Program provides $25,000 in protein expression tools to advance scientific discovery.
Friday, July 16, 2010
Thermo Fisher Scientific Launches Maybridge Ro3 Diversity Fragment Library
Diverse set of 1,500 molecules engineered for high-quality fragment screening-based programmes.
Tuesday, July 06, 2010
Thermo Fisher Scientific Opens Global Food Safety Response Center
Designed to aid governments and businesses facing unknown food safety threats involving chemical contaminants.
Friday, April 16, 2010
Thermo Fisher Scientific Opens New UK Facility for Cancer Diagnostics and Chromatography Products
The new facility houses Thermo Fisher’s Anatomical Pathology and Chromatography Consumables businesses.
Thursday, February 11, 2010
Thermo Fisher Scientific Names Recipients of RNAi Discovery Grants
More than $400,000 in RNAi screening tools awarded to advance biomedical research and drug discovery.
Friday, November 06, 2009
Thermo Fisher Scientific to Showcase Innovative Mass Spectrometry Solutions at IMSC 2009
Company will showcase a variety of mass spectrometry software and hardware solutions to deliver improved analytical performance.
Monday, September 07, 2009
Thermo Fisher Scientific Collaborates with the Institute of Cancer Research to Create Proteomics Laboratory
The ICR's new, proteomics laboratory is equipped with a complete Thermo Scientific proteomics workflow.
Friday, July 24, 2009
Cancer Research Technology Selects Maybridge Fragments for Lead Discovery Programmes
CRT purchases 2,000 Maybridge Fragments as the foundation of its new fragment screening library.
Friday, May 22, 2009
Thermo Fisher Scientific’s Exactive LC-MS Wins ACHEMA Innovation Award
The Company has been presented with the award for the category of Laboratory and Analytical Techniques.
Friday, May 22, 2009
Thermo Fisher Scientific Event Showcases New Breakthroughs in FAIMS
Attendees presented a number of breakthroughs enabled through their use of the FAIMS technology.
Friday, May 08, 2009
Scientific News
Turning Skin Cells into Heart, Brain Cells
In a major breakthrough, scientists at the Gladstone Institutes transformed skin cells into heart cells and brain cells using a combination of chemicals.
Experimental Drug Cancels Effect from Key Intellectual Disability Gene
A University of Wisconsin—Madison researcher who studies the most common genetic intellectual disability has used an experimental drug to reverse — in mice — damage from the mutation that causes the syndrome.
Doubling Down on Dengue
HMS researchers have discovered two ways a compound blocks dengue virus.
Reprogramming Scorpion Venom
‘Twist of nature’ neutralizes toxin.
Tailoring a Suit for Tumor-Penetrating Cancer Meds
For more than a decade, biomedical researchers have been looking for better ways to deliver cancer-killing medication directly to tumors in the body.
Resurrecting an Abandoned Drug
Previously discarded drug shows promise in helping human cells in a lab dish fight off two different viruses.
Safer, Cheaper, Greener and More Efficient System for Organic Synthesis
The new medium not only supports organic synthesis it also produces considerably higher yields of product than pure organic solvents.
Fighting Prostate Cancer
Identifying the most promising compounds which can be used as medications for prostate cancer.
Collaboration to Develop Cancer Therapeutics
Major license agreement with Merck, enabled by Blavatnik Biomedical Accelerator, aims to develop therapy for most common form of acute leukemia.
Faster UVA Molecular Analysis Technology
There are people in the world – chemical engineers, astronomers, national defense scientists investigating an explosion – who need to know just what something is made of, down to the molecular level.
SELECTBIO

SELECTBIO Market Reports
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,000+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,500+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!