Corporate Banner
Satellite Banner
Medicinal Chemistry
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

New Screening Library Offers Exceptional Chemical Diversity to Increase Hit Probability

Published: Thursday, June 12, 2014
Last Updated: Thursday, June 12, 2014
Bookmark and Share
Delivering highly diverse coverage of drug-like chemical space in a single library.

A new highly diverse library of screening compounds is designed to maximize efficiency and productivity for researchers in early phase small molecule drug discovery.

By delivering exceptionally diverse coverage of the space spanned by all possible drug-like molecules and associated characteristics, the Maybridge HitCreator library provides a greater hit probability than larger, but less diverse, screening libraries.

The Maybridge HitCreator library consists of 14,000 screening compounds selected for maximum diversity by rigorous analysis of more than 500,000 commercially available screening compounds.

Each Maybridge HitCreator diversity library is conveniently available off the shelf and supplied as dry films in Thermo Scientific Matrix 96 shallow-well plates or 384-well microplates.

“Diversity-based screening is a vital tool for discovering new molecules that could potentially influence drug discovery. However, the wide range of commercially available screening libraries is daunting for scientists to pick the ideal library for their specific requirements,” said Simon Pearce, product marketing manager, Global Chemicals, Thermo Fisher Scientific. “Our new Maybridge HitCreator library simplifies this challenge through its exceptional diversity. It removed the need to choose between different libraries and covers all drug-like chemical space to provide cost effective hit reliability from a single library.”

Building on more than 50 years in designing proven libraries, all compounds within the Maybridge HitCreator are meticulously selected for a high hit probability. All are drug-like and conform to Lipinski’s “Rule of Five”, ensuring they possess key physicochemical properties frequently found in orally active drugs, as well as additional filters.

These include optimization to ensure a drug can readily permeate cells, therefore HitCreator compounds are selected to have a Polar Surface Area (PSA) of ≤ 140Å2. In addition, all compounds have been screened to remove inappropriate chemical structures, reducing the chance of “false hits.


Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,400+ scientific posters on ePosters
  • More than 3,700+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Thermo Completes Sale of Cole-Parmer to GTCR
Thermo Fisher Scientific Inc. announced that it has completed the sale of its Cole-Parmer customer channel business to private equity firm GTCR LLC for approximately $480 million in cash.
Wednesday, August 20, 2014
Thermo to Sell Cole-Parmer for $480M
Company has signed a definitive agreement to sell its Cole-Parmer channel business to private equity firm GTCR, LLC for $480 million in cash.
Monday, July 21, 2014
Thermo Scientific Selected to Supply Maybridge Fragment Library for Key Research
Recommended for use by renowned fragment library design expert.
Tuesday, February 05, 2013
Record Revenues for Thermo Fisher Scientific
Revenue for the quarter grew 6% to $3.26 billion in 2012, versus $3.09 billion in 2011.
Thursday, January 31, 2013
Thermo Scientific Announces New UHPLC/MS Method for Trace-Level Analysis of Perfluorinated Compounds in Human Breast Milk
The method utilizes SRM and H-SRM on an integrated UHPLC/MS platform enables robust detection of PFCs at ppt concentrations.
Friday, August 27, 2010
Thermo Fisher Scientific Names Recipients of In Vitro Protein Expression Grants
Program provides $25,000 in protein expression tools to advance scientific discovery.
Friday, July 16, 2010
Thermo Fisher Scientific Launches Maybridge Ro3 Diversity Fragment Library
Diverse set of 1,500 molecules engineered for high-quality fragment screening-based programmes.
Tuesday, July 06, 2010
Thermo Fisher Scientific Opens Global Food Safety Response Center
Designed to aid governments and businesses facing unknown food safety threats involving chemical contaminants.
Friday, April 16, 2010
Thermo Fisher Scientific Opens New UK Facility for Cancer Diagnostics and Chromatography Products
The new facility houses Thermo Fisher’s Anatomical Pathology and Chromatography Consumables businesses.
Thursday, February 11, 2010
Thermo Fisher Scientific Names Recipients of RNAi Discovery Grants
More than $400,000 in RNAi screening tools awarded to advance biomedical research and drug discovery.
Friday, November 06, 2009
Thermo Fisher Scientific to Showcase Innovative Mass Spectrometry Solutions at IMSC 2009
Company will showcase a variety of mass spectrometry software and hardware solutions to deliver improved analytical performance.
Monday, September 07, 2009
Thermo Fisher Scientific Collaborates with the Institute of Cancer Research to Create Proteomics Laboratory
The ICR's new, proteomics laboratory is equipped with a complete Thermo Scientific proteomics workflow.
Friday, July 24, 2009
Cancer Research Technology Selects Maybridge Fragments for Lead Discovery Programmes
CRT purchases 2,000 Maybridge Fragments as the foundation of its new fragment screening library.
Friday, May 22, 2009
Thermo Fisher Scientific’s Exactive LC-MS Wins ACHEMA Innovation Award
The Company has been presented with the award for the category of Laboratory and Analytical Techniques.
Friday, May 22, 2009
Thermo Fisher Scientific Event Showcases New Breakthroughs in FAIMS
Attendees presented a number of breakthroughs enabled through their use of the FAIMS technology.
Friday, May 08, 2009
Scientific News
Toxin from Salmonid Fish has Potential to Treat Cancer
Researchers from the University of Freiburg decode molecular mechanism of fish pathogen.
New Diabetes Drug has Unexpected Side Effect
A type of drug used to treat diabetes may reduce the risk of developing Parkinson’s disease, according to new research.
Researchers Develop Vaccine that Protects Primates Against Ebola
A collaborative team from The University of Texas Medical Branch at Galveston and the National Institutes of Health have developed an inhalable vaccine that protects primates against Ebola.
Cannabis May Be Used to Treat Fractures
TAU researcher finds non-psychotropic compound in marijuana can help heal bone fissures.
A Novel Drug to FIght Malaria
An international team of scientists has announced that a new compound to fight malaria is ready for human trials.
New Cell Structure Finding Might Lead to Novel Cancer Therapies
University of Warwick scientists in the U.K. say they have discovered a cell structure which could help researchers understand why some cancers develop.
Creating More Potent Vaccines
Yale researchers uncovered a new role for a type of immune cell, known as regulatory T cells, in promoting long-term immunity.
Potential Therapeutic for Blinding Eye Disease
NIH research points to microglia as potential therapeutic target in retinitis pigmentosa.
Potential New Class of Cancer Drugs
Scientists have found a way to stop cancer cell growth by targeting the Warburg Effect, a trait of cancer cell metabolism that scientists have been eager to exploit.
Global Search for Next Antibiotic
University of Queensland researchers have launched a global search to discover antibiotics capable of combating superbug bacteria that are resistant to current antibiotics.
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,400+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
3,700+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FREE!