|Human iPSC-derived hepatocytes and cardiomyocytes for drug toxicity testing|
AnnandRR; Vardaro R; Hamilton B; Akakira R; Tamura K; Yoshida S; Lin YC; Toyoda D; Kogami H; Okuda Y; Watanabe T; Inamura M
Human iPS-derived hepatocytes (ReproHepato™) and cardiomyocytes (ReproCardio 2™) are useful for in vitro toxicity assays.
|Applications of scCO2 as a “Green” Solvent in the Textile Industry|
A. Lutz, A. Kaziunas, R. Schlake, M. Anand, and J.P. Hobbs
Using Supercritical CO2 to dye textiles.
|Using Cresset to grow and link distant fragment hits with sensible chemistry |
M J Slater; T Cheeseright
We describe a further extension to our fragment growing methodology to aid fragment optimisation through linking fragments that have been shown to bind to distinct (distant or adjacent) pockets.
|A multi-resonances valveless micropump with high fluid transportation efficiency|
Ming-Che Hsieh, Min-Fan Huang, and An-Bang Wang
A multi-resonances valveless micropump equipping with inlet/outlet elastic chambers of intendedly-designed stiffness was successfully realized to solve the low efficiency problem. Besides, a theoretical model based on Hydraulic-electrical-Analogy was also proposed to precisely predict its characteristics of dynamic behavior.
|Rate and Mechanistic Investigation of Eu(OTf)2-Mediated Reduction of Graphene Oxide at Room Temperature|
Tufan Ghosh, Sandeepan Maity and Edamana Prasad
Eu(OTf)2 has been introduced as an efficient reagent for the reduction of graphene oxide. Details kinetic studies have been performed which suggests that, the method is more efficient compared to that of other commonly used reduction methods.
|Droplet-on-Demand Platform for Biochemical Screening & Drug Discovery|
L.D. van Vliet1*, F. Gielen1, A. Sinha2, B.T. Koprowski3, J.B. Edel4, X.Niu5, A.J. deMello3, F. Hollfelder1, & J. Motschman2
To demonstrate droplet on demand applications towards study of biological entities encapsulated in nanoliter droplets. Interfacing a droplet on demand platform with microfluidic chips allows for merging and dilution of droplets. This feature is applied to encapsulate yeast cells (S. cerevisiae) and multicellular organisms (C. elegans).
|Direct Targets Identification of a Bioactive Compound|
Sylvain Blanc, Paul Bradley, Marie-Edith Gourdel, Michael Cholay, Gisèle Guimèse, Mike Mckenzie, George Nasi, Jean-Christophe and Barbara Ruggiero
Identifying protein partners of a small bioactive molecule is of great
interest in many aspects of life sciences and specifically in the drug
discovery and development process cycle. It is a support to (i) decipher
the mechanism of action after for example a “High Content” screening,
(ii) study “off-target” effects, (iii) adjust therapeutic indications and
clinical regimens of a drug and (iv) consider drug repositioning.
|3D-Tissue/ Whole-blood Co-culture Models Combined with Multi-Analyte Profile (MAP) Analyses for In-vivo-like Immunopharmacology|
Stein GM, Joos T, Schmolz M
Human Organotypic Test (HOT) Systems aim at in-vivo like substance characterisation of all preparations meant to act on the human immune system.
|Phenotypic Screening Applied to the Anti-biofilm Drug Discovery: Identification of Anti-biofilm Flavonoids from a Chemical Library|
Suvi Manner1*, Malena Skogman2, Pia Vuorela2, Adyary Fallarero2
This work represents a systematic exploration of a flavonoids collection for the inhibitory activity against Staphylococcus aureus biofilms and offers an improved methodological workflow for anti-biofilm screens of chemical libraries taking into account the connections between anti-biofilm and antibacterial properties.