An Automated, Cell-based Platform for the Rapid Detection of Novel Androgen Receptor Modulators

AR activity is regulated through the binding of androgenic hormones (eg., testosterone and di-hydroxy testosterone). In turn, AR functions to regulate the expression of a myriad of genes involved in metabolic processes, cell proliferation/apoptosis, and male sexual differentiation and development. AR dysfunction often has severe health implications, such as androgen insensitivity syndrome and prostate cancer. Consequently, AR commands much attention as a target for the discovery and development of improved drugs. In particular, anti-androgens comprise an important class of drugs used in the treatment prostate cancer.