Fall in Deaths Following Withdrawal of Pain KillerReduction in deaths after withdrawn of pain-relief drug co-proxamol in UK.
Interfacing Medicinal Chemistry with Structural BioinformaticsThe observed aaRS-specific stability differences between key riboswitch structural elements could potentially be targeted to effect ligand-specificity in future drug discovery efforts.
Revolutionary New Cancer Targeting Technology Described in Nature MedicineImmunocore scientists manage to overcome cancer problem by boosting the ability of cancer-specific TCRs.
Anti-HIV Drug Use During Pregnancy Does Not Affect Infant Size, Birth WeightNIH study indicates drug safe during pregnancy, but infants smaller at first birthday.
Prosonix Demonstrates Improved Delivery and Co-localization of Respiratory MedicinesNew review published in European Respiratory Disease(ERD).
Design, Synthesis and Activity Study of Aminopeptidase N Targeted AHPA DerivativesAPN was shown to be involved in the degradation of extracellular matrix in tumor invasion and may serve as a target receptor for drug delivery into tumors and also contribute to angiogenesis.
Researchers Turn Big Data Problems into Advanced Biology and Drug DiscoveriesUniversity of Illinois at Chicago and The Genome Analysis Centre in Norwich, UK leverage SGI(R) UV(TM) to accelerate drug discovery and complex problem analysis.
New Research on Zebrafish Brings a Cure for Hearing Loss CloserZebrafish to discover drugs that may lead to the restoration of hearing.
Enabling Large-Scale Design, Synthesis and Validation of Small Molecule Protein-Protein AntagonistsWith the number of new drug applications (NDA) on the decline, a new approach that stops our dependence from old compounds, and utilizes the vast information available on protein interactions and structure, is desperately needed.
Preclinical Predictors of Anticancer Drug Efficacy: Critical Assessment with Emphasis on Nanomolar PotencyThis article looks at prediction of cancer drug efficacy in its ultimate user, the human patient and reviews current knowledge followed by illustrative examples that, in the absence of definitive data, provide an empirical perspective.
