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Flow Aqueous Work-up Using FLLEX
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Syrris Ltd

This application note demonstrates the use of the Africa FLLEX (Flow Liquid Liquid EXtraction) module for performing post reaction automated liquid-liquid extraction in a standard Africa flow system. An amide coupling reaction was performed in the Africa system and worked up by extraction with aqueous bicarbonate to remove by-products. The quality of extraction and separation was the same batch.

The FLLEX module is a continuous flow contacting and separating system based on a small PTFE membrane separator. By accurately controlling the cross membrane pressure, the organic phase can be forced through the membrane whilst the aqueous phase is retained. An optical sensing system monitors the purity of both output flow streams and can optimise separation conditions. The FLLEX internal volume is 100 microlitres and total flow rates of 0.5mls/min and above are possible.

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