Corporate Banner
Satellite Banner
Medicinal Chemistry
Scientific Community
Become a Member | Sign in
Home>Resources>Application Notes>This Application Note
  Application Notes
Scientific News
Atriva Therapeutics GmbH Develops Innovative Flu Drug
Highly effective against seasonal and pandemic influenza.
Study Removes Cancer Doubt for Multiple Sclerosis Drug
Researchers from Queen Mary University of London are calling on the medical community to reconsider developing a known drug to treat people with relapsing Multiple sclerosis after new evidence shows it does not increase the risk of cancer as previously thought.
New Hope for Personalized Treatment of Eczema
Pharmaceutical researchers at Oregon State University have developed a new approach to treat eczema and other inflammatory skin disorders that would use individual tests and advanced science to create personalized treatments based on each person's lipid deficiencies.
Inroads Against Leukaemia
Potential for halting disease in molecule isolated from sea sponges.
Researchers Disguise Drugs As Platelets to Target Cancer
Researchers have for the first time developed a technique that coats anticancer drugs in membranes made from a patient’s own platelets.
HIV Patients Should Be Included in Early Clinical Trials of Anti-TB Drugs
Tuberculosis is the number one cause of death in HIV-infected patients in Africa and a leading cause of death in this population worldwide.
Combination Drug Therapy Shrinks Pancreatic Tumors In Mice
Two drugs that affect the structure and function of DNA have been found to block the growth of pancreatic tumor cells in mice, researchers hope the drugs can soon be tested in humans with the disease.
Seeking A Better Way To Design Drugs
NIH funds research at Worcester Polytechnic Institute to advance a new chemical process for more effective drug development and manufacturing.
Old Drug Performs New Tricks
Cambridge-led research reveals the powers of a "wonder drug" that has lain under the noses of doctors for 50 years.
Diabetes Drugs May Actually Release Sugar Into the Blood
A family of drugs used to treat Type 2 diabetes could promote the release of sugars into the blood - something the drugs are supposed to prevent, Cambridge scientists have claimed.
Scroll Up
Scroll Down

The Forced Degradation (De-esterification) of Parabens Using a Microreactor Flow System
Bookmark and Share

Syrris Ltd

Product degradation studies are an important test for any pharmaceutical or other high value active material. These experiments generally expose the material to an external stress to assess the stability of the constituents or formulation. External stresses may include temperature, pH, light, moisture, and even exposure to other materials within the product formulation, and their degradation products.

Conventionally, degradation tests can take very long periods of time, because standard testmethods require the materials to be exposed to stress factors for periods of weeks or longer, andthen tested using standard analytical methods.

Accelerated testing is of clear benefit. Use of elevated temperature to increase the rate ofinteractions is the most powerful factor to shorten the length of time required for these tests.However, conventional batch techniques are of limited use for such accelerated testing, as theapproach is not readily amenable to carrying out a wide range of tests at varying temperature and storage time. It is also difficult to achieve temperatures near or beyond reflux without specialprecautions; achieving such temperatures is typically required to achieve significant rateacceleration.

An ideal forced degradation test system would have a number of useful properties:

  • Ability to accelerate tests by a factor of 10 to 100 fold or more (e.g. 1 hour to 1 minute = 60 fold)
    • Requires holding sample at temperatures well above reflux
  • Ability to process and manage multiple samples under multiple times and temperatures
    • Requires sample introduction, tracking and storage capability
  • Ability to introduce a range of contaminant materials
    • Requires injection and mixing systems
  • Ability to introduce other stresses
    • Requires capability to expose to light, etc.
  • Ability to sample automatically and collate data
    • Requires integrated analytical capability

Flow systems are ideal for this application, as they meet all of the above requirements in acompact and integrated instrument. A further benefit is that the use of microreactors allows teststo be performed with very small amounts of material, reducing cost and storage space.

This application note describes the use of an Africa flow system to conduct a forced degradationstudy on a series of Parabens (common pharmaceutical preservatives). Solutions of methyl, ethyland propyl paraben are susceptible to de-esterification in the presence of alkali. The flow reactorsystem allows several different levels of exposure to be investigated within a single experiment.Variables such as concentration, temperature and reaction time can be changed to determine thestability of the paraben. A major advantage of the Africa flow system is that the pressureregulation of the system means that temperatures beyond the boiling points of reaction solventscan be used. In these experiments the concentrations of the reactants was held constant whilstboth reaction time and temperature were varied.

Further Information

Related Content

Syrris Invites Chemists to Join Free Flow Chemistry Workshop in the US
Syrris is hosting a free flow chemistry workshop in Cambridge, Massachusetts, USA, on the 9th of May 2013.
Monday, April 22, 2013
Syrris Acclaimed for Latin American Presence
Extensive progress acknowledged following the opening of the Brazilian subsidiary.
Saturday, October 09, 2010
Syrris Announces Outstanding Success Following Expansion of Worldwide Operations
The Company has experienced strong 2010 start by opening its Brazilian subsidiary and new product launches.
Friday, July 16, 2010
Syrris to Host Technical Seminars in India for R&D Chemists
Applications-focused seminars to explore calorimetry, sonocrystallization and flow chemistry solutions.
Monday, May 10, 2010
Syrris Establishes Indian Subsidiary
Company expands its sales network and service support for all customers in India.
Monday, July 27, 2009
Syrris to Further Extend its Global Outreach with new Distributors Across Europe, Asia and the Middle East
Syrris has appointed three sales and customer support personnel and six distributors to support its new modular flow chemistry and synthesis systems.
Thursday, December 06, 2007
Academics Get to Test Flow Chemistry System for Free
Syrris has announced the winners of its competition to win the use of its new FRX300 flow chemistry system.
Monday, October 22, 2007
Win a Flow Chemistry System
Syrris is providing scientists with the opportunity to win one month’s free use of one of its FRX systems, the FRX300, including delivery, training and system support.
Monday, June 18, 2007
Syrris Announce new West Coast Office
To meet the growing Customer demand, Syrris expands its US sales and customer service team with the opening of an office in La Jolla, CA, to provide support for its modular flow chemistry and synthesis products.
Thursday, March 15, 2007
Buoyant Order Book Spurs Recruitment Drive at Syrris
Syrris to double sales force for its FRX and atlas as these systems demonstrate the success of the modular approach.
Tuesday, January 30, 2007
Syrris Appointed as North American Distributor of Lara and Coflux Product Lines
Syrris will be exhibiting Lara and Coflux at the forthcoming Cambridge Healthcare Institute Process R&D Summit in Philadelphia.
Monday, October 03, 2005
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,600+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
3,800+ scientific videos