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Designing Drugs with a Whole New Toolbox
Researchers develop methods to design small, targeted proteins with shapes not found in nature.
Small Molecules Lead to a Big Change in Reaction Outcomes
Scientists have changed the behaviour of a group of molecules involved in carbon-oxygen bond synthesis.
Targeting Fat to Treat Cancer
Researchers develop novel cancer treatment that halts fat synthesis in cells, stunting tumors.
Hyperstable Peptides for 'On-Demand' Drugs
These small molecules can fold into different conformations that could allow for greater flexibility in precision drug design
Drug Leads Identified to Combat Heart Disease
Using three supercomputers, researchers surveyed protein structures through accelerated molecular dynamics.
Accelerating the Path to Molecules for Medicine
Researchers convert carbon-hydrogen bonds into nitriles - converting organic molecules into components of medicines.
New Hope for Zika Treatment Found in Large-Scale Screen of Existing Drugs
Johns Hopkins researchers join collaborative group to screen 6,000 existing drugs in hopes of finding treatments for Zika Virus infection
Game Changing Antibacterial Drug Research
Researchers publish report on the synthesis of a newly discovered “game-changing” antibiotic, Teixobactin.
New Way of Displaying 3D Molecular Structures
Metal-organic frameworks provide a new platform for solving the structure of hard-to-study samples.
Agent Blocks Pain Without Morphine's Side Effects
Scientists have synthesised a molecule with specific pain-relief properties and has shown its efficacy in mice.
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AMRI

Rising R&D costs, increasing expectations in the areas of productivity and quality, and a growing need to establish operations in close proximity to emerging markets are driving the international expansion of drug-discovery organizations. This global shift is driving new trends in the area of career development and hiring, such as the need for experienced scientific professionals at different locations all over the globe. Although the global pharmaceutical industry is going through significant changes, the role of medicinal chemistry in identifying and optimizing potential new drug candidates remains substantial. Going forward, current and future candidates in the area of medicinal chemistry and other scientific disciplines who have a willingness to work overseas may gain a competitive advantage when entering or advancing within the drug discovery field. 

During the past 10 years, there has been limited growth in the number of approved new chemical entities entering the marketplace in spite of a significant increase in overall R&D spending. For a number of reasons, R&D activities have also become more global during this time. As a result of this globalization associated with expanding international operations, there is an increased need for talent – principally with discovery and development skill sets – that may favor candidates who are willing to consider working in these non-traditional locations. 

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