Corporate Banner
Satellite Banner
Medicinal Chemistry
Scientific Community
 
Become a Member | Sign in
Home>Videos>This Video
  Videos

Return

Strategic Applications of Flow Chemistry within Drug Discovery
Pfizer, Inc.

Despite the significant growth of interest in Flow Chemistry, it is often challenging to integrate this into research programs. Given the fast paced nature of drug discovery, and the growing constraint on resources, it is important to recognize opportunites to utilize Flow Chemistry at times when it can bring the maximum benefit to the program under study. This talk will look at several scenarios where this has been implemented within Pfizer. Firstly, one of the key interests is the opportunity to rapidly expand into novel chemical space, which is important both from a proprietary and pharmacological properties standpoint. Development of robust flow methodologies with a particular focus on library generation offers a unique opportunity to do this. Secondly, one of the most significant advantages of working in Flow is the ability to work with hazardous reagents, and examples of this will also be presented. Finally, expediting compounds as they progress is enabled through use of Flow by simply “scaling out” processes as opposed to “scaling up”. This talk will touch on the interaction between medicinal chemistry and process chemistry, and look at some of the benefits of screening chemistries to make them more amenable to flow with this in mind.

Request more information
Company product page

Scientific News
Survey of New York City Soil Uncovers Medicine-Making Microbes
Microbes have long been an invaluable source of new drugs. And to find more, we may have to look no further than the ground beneath our feet.
Drug Design Strategy to Improve Breast Cancer Treatment
Scientists develop novel structure-based drug design strategy aimed at altering the basic landscape of hormone-driven breast cancer treatment.
`Molecular Commando’ Identified to Tackle Hypoxia Pathway
Scientists identify 'molecular commando' that can activate hypoxic response, which helps combat a number of conditions.
Peer Review is in Crisis, But Should be Fixed, Not Abolished
After the time to get the science done, peer review has become the slowest step in the process of sharing studies, and some scientists have had enough.
Two Antibiotics Fight Bacteria Differently Than Thought
Researchers discover that two widely prescribed antibiotics may fight bacteria differently than previously thought.
Drug Target for Gastrointestinal Stromal Tumors Identified
Researchers show the Hedgehog signaling pathway is central to the formation of gastrointestinal stromal tumors.
Structure of Primary Cannabinoid Receptor is Revealed
The findings provide key insights into how natural and synthetic cannabinoids including tetrahydrocannabinol —a primary chemical in marijuana—bind at the CB1 receptor to produce their effects.
Targeting Cannabinoid CB2 Receptors in the CNS
With endogenous cannabinoids considered as a potential target to combat CNS diseases, this article examines the role of CB2R could play in fighting some disorders.
3D-Printing in Science: Conference Co-Staged with LABVOLUTION
LABVOLUTION 2017 will have an added highlight of a simultaneous conference, "3D-Printing in Science".
Charles River Acquires Agilux
Enhances Charles River’s early-stage capabilities in bioanalytical services.
SELECTBIO

SELECTBIO Market Reports
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
4,000+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
5,300+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!