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Scientific News
Misfolded Proteins Clump Together in a Surprising Place
Stowers researchers create new framework for protein aggregation under acute stress.
Nanoparticle Research Could Enhance Drug Delivery Through Skin
A milestone study from the University of Southampton could have major implications for the delivery of drugs.
Chemists Recruit Anthrax to Deliver Cancer Drugs
With some tinkering, a deadly protein becomes an efficient carrier for antibody drugs.
Protein ‘Map’ Could Lead to Potent New Cancer Drugs
Findings will help scientists to design drugs that could target NMT enzyme.
Animal Testing can Mislead Drug Discovery and Development
Several blockbuster drugs would not be on the market, if scientists had relied solely on drug-uptake in animal trials, according to new research.
Synthesis and Bioactivity of Analogues of Tropodithietic Acid
The study suggests that the sulfur atoms in the marine antibiotic TDA are not essential for bioactivity, but different modes of action for TDA and its sulfur-free analogue cannot be excluded.
Cancer-Fighting Drugs Might Also Stop Malaria Early
A number of compounds have been identified which could be used to fight malaria.
Collaboration Leads to Possible Shortcut to New Drugs
The reaction, reported in Science, demonstrates how a carboxylic acid can be transformed into a very reactive site through use of a novel photoredox catalyst.
Catalysts That Mimic Enzymes Could Revolutionize Pharmaceutical Manufacturing
Structures made of polymer chains allow the catalysts to work in water.
Discovery of How Taxol Works Could Lead to Better Anticancer Drugs
The drug’s interference with the normal function of microtubules could help in designing better anticancer drugs.

Continuous Flow Synthesis of alpha-Haloketones – Essential Building Blocks of Antiretroviral Agents
Oliver Kappe, Karl Franzens University of Graz, speaking at Flow Chemistry Congress 2014

Catalysis in Flow: Operando Study of Pd Catalyst Speciation and Leaching
Mimi Hii, Imperial College, speaking at Flow Chemistry Congress 2014.

TagLite® 2 cell assay - the next dimension to discovering new antibody drugs
Sandra Grau-Richards, Senior Scientist/Team Leader Roche-Glycart

Drug-drug combinations made simple
Roderick L. Beijersbergen, Associate Professor Division of Molecular Carcinogenesis and Head NKI Robotics and Screening Center.

Druggability of Dynamic Protein-Protein Interfaces
Volkhard Helms, Universitat des Saarlandes, speaking at Discovery Chemistry Congress 2013.

Library Design for Tackling Protein-protein Interactions: The 2P2I Approach
Dr Philippe Roche, CNRS, speaking at Discovery Chemistry Congress 2013.

Approaches to the Discovery of Small-molecule MDM2-p53 Inhibitors
Dr Ian Hardcastle, Newcastle University, speaking at Discovery Chemistry Congress 2013.

How to Make Yeast Tremble and Suffer Energy Loss: Yeast Models for Prion and Mitochondrial Diseases
Professor Marc Blondel, Université de Bretagne Occidentale, speaking at Discovery Chemistry Congress 2013.

Towards the Systematic Exploration of Chemical Space: Design, Synthesis and Exploitation of Diverse Small Molecular Libraries
Dr Richard Doveston, University of Leeds, speaking at Discovery Chemistry Congress 2013.

Chemical Proteomics: Drug Targets, Drug Selectivity, MoA and Resistance
Dr. Guillaume Médard, Technische Universität München, speaking at Discovery Chemistry Congress 2013.

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