Medicinal Chemistry - The Online Scientific Community

Rapid Bone Loss Possible Side Effect of Anti-Obesity Drug
Research from UT Southwestern Medical Center has raised concern about the safe use of fibroblast growth factor 21.

Compugen Cancer Target Results Demonstrate Significant Potential for Cancer Immunotherapy
Findings support CGEN-15001T's potential as a powerful drug target for cancer immunotherapy.

Synthesis, Characterization and Biological Activity Studies of 1,3,4-Oxadiazole Analogs
Some of the compounds prepared were shown to possess remarkable antibacterial, antifungal and anti-inflammatory activities.

Natural Product Biosyntheses in Cyanobacteria: A Treasure Trove of Unique Enzymes
Researchers from the University of Potsdam review biochemical studies of cyanobacterial pathways and how this can inspire the development of concepts for the design of bioactive compounds.

Ganetespib Synergizes with Taxanes in Multiple Non-small Cell Lung Cancer Models
Combination of ganetespib with microtubule stabilizers, docetaxel and paclitaxel, or destabilizers, vincristine, was shown to result in synergistic anticancer activity.

Idera Pharmaceuticals Announces Selection of Toll-like Receptor (TLR) Agonist Candidates for Evaluation as Vaccine Adjuvants by Merck
The partners announced the selection of several novel agonists targeted to TLR7, TLR8 or TLR9 for evaluation and use as vaccine adjuvant candidates under the companies' collaboration and license agreement.

SCYNEXIS and Medicines for Malaria Venture (MMV) Sign HEOS® Agreement
The software is a comprehensive, web-based drug research information management system that supports geographically distributed scientists and facilitates collaboration.

Patent Pheromones: Attracting Money, Repelling Infringement, Prompting a Mating Response Thomas Saunders, Of Counsel, Rissman Hendricks & Oliverio, speaking at Medchem Europe 2011.
Latent Hit Identification in Primary Screening Data with Compound Set Enrichment Thibault Varin, PostDoctoral Fellow, Novartis, Speaking at Medchem Europe 2011.
Current Perspectives in Fragment Based Ligand Discovery Roderick Hubbard, Professor, University of York, speaking at Medchem Europe 2011
Approach to Quick Lead Optimization Including Physicochemical and ADME Profiling Pranas Japertas, Director, ACD Labs, Speaking at Medchem Europe 2011.
Renin Inhibitors: A Journey Through Polarity, Size and Potency Olivier Bezençon, Chemistry Project Leader and Senior Group Leader, Actelion Pharmaceuticals, speaking at Medchem Europe 2011.
State-of-the-Art in Ligand-Based Virtual Screening Jürgen Bajorath, Professor, Department of Life Science Informatics, University of Bonn, speaking at Medchem Europe 2011.
‘Better Compounds Faster’ – The Development and Exploitation of a Desktop Predictive Chemistry Toolkit John Cumming, Global Programme Manager for Predictive Chemistry, AstraZeneca R&D, speaking at Medchem Europe 2011.
Thermodynamics Guided Lead Discovery and Optimization György M. Keseru, Head of Discovery Chemistry, Gedeon Richter, speaking at Medchem Europe 2011.
Enhancing Success Rates in Virtual Screening Giulio Rastelli, Associate Professor in Medicinal Chemistry at the University of Modena, speaking at Medchem Europe 2011.
How to Obtain a Solid Track Record in Medicinal Chemistry Research Services Bruno Giethlen, Chief Scientific Officer, Prestwick Chemicals speaking at Pharma Outsourcing Congress 2011

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