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Scientific News
Misfolded Proteins Clump Together in a Surprising Place
Stowers researchers create new framework for protein aggregation under acute stress.
Nanoparticle Research Could Enhance Drug Delivery Through Skin
A milestone study from the University of Southampton could have major implications for the delivery of drugs.
Chemists Recruit Anthrax to Deliver Cancer Drugs
With some tinkering, a deadly protein becomes an efficient carrier for antibody drugs.
Protein ‘Map’ Could Lead to Potent New Cancer Drugs
Findings will help scientists to design drugs that could target NMT enzyme.
Animal Testing can Mislead Drug Discovery and Development
Several blockbuster drugs would not be on the market, if scientists had relied solely on drug-uptake in animal trials, according to new research.
Synthesis and Bioactivity of Analogues of Tropodithietic Acid
The study suggests that the sulfur atoms in the marine antibiotic TDA are not essential for bioactivity, but different modes of action for TDA and its sulfur-free analogue cannot be excluded.
Cancer-Fighting Drugs Might Also Stop Malaria Early
A number of compounds have been identified which could be used to fight malaria.
Collaboration Leads to Possible Shortcut to New Drugs
The reaction, reported in Science, demonstrates how a carboxylic acid can be transformed into a very reactive site through use of a novel photoredox catalyst.
Catalysts That Mimic Enzymes Could Revolutionize Pharmaceutical Manufacturing
Structures made of polymer chains allow the catalysts to work in water.
Discovery of How Taxol Works Could Lead to Better Anticancer Drugs
The drug’s interference with the normal function of microtubules could help in designing better anticancer drugs.

Alpha2* Nicotinic Acetylcholine Receptors as a Therapeutic Target for Memory Enhancement
Dr Katumi Sumikawa, University of California, speaking at Ion Channel Targets 2011.

Smooth Muscle Kv7 (KCNQ) Potassium Channels: Important New Therapeutic Targets
Professor Kenneth Byron, Loyola University Chigaco, speaking at Ion Channel Targets 2011.

Protons, Heat and Mechanical Force Converge to Gate Two-Pore Potassium Channels at the Selectivity Filter
Dr Slav Bagriantsev, University of California, speaking at Ion Channel Targets 2011.

Patent Pheromones: Attracting Money, Repelling Infringement, Prompting a Mating Response
Thomas Saunders, Of Counsel, Rissman Hendricks & Oliverio, speaking at Medchem Europe 2011.

Latent Hit Identification in Primary Screening Data with Compound Set Enrichment
Thibault Varin, PostDoctoral Fellow, Novartis, Speaking at Medchem Europe 2011.

Current Perspectives in Fragment Based Ligand Discovery
Roderick Hubbard, Professor, University of York, speaking at Medchem Europe 2011

Approach to Quick Lead Optimization Including Physicochemical and ADME Profiling
Pranas Japertas, Director, ACD Labs, Speaking at Medchem Europe 2011.

Renin Inhibitors: A Journey Through Polarity, Size and Potency
Olivier Bezençon, Chemistry Project Leader and Senior Group Leader, Actelion Pharmaceuticals, speaking at Medchem Europe 2011.

State-of-the-Art in Ligand-Based Virtual Screening
Jürgen Bajorath, Professor, Department of Life Science Informatics, University of Bonn, speaking at Medchem Europe 2011.

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