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Scientific News
Misfolded Proteins Clump Together in a Surprising Place
Stowers researchers create new framework for protein aggregation under acute stress.
Nanoparticle Research Could Enhance Drug Delivery Through Skin
A milestone study from the University of Southampton could have major implications for the delivery of drugs.
Chemists Recruit Anthrax to Deliver Cancer Drugs
With some tinkering, a deadly protein becomes an efficient carrier for antibody drugs.
Protein ‘Map’ Could Lead to Potent New Cancer Drugs
Findings will help scientists to design drugs that could target NMT enzyme.
Animal Testing can Mislead Drug Discovery and Development
Several blockbuster drugs would not be on the market, if scientists had relied solely on drug-uptake in animal trials, according to new research.
Synthesis and Bioactivity of Analogues of Tropodithietic Acid
The study suggests that the sulfur atoms in the marine antibiotic TDA are not essential for bioactivity, but different modes of action for TDA and its sulfur-free analogue cannot be excluded.
Cancer-Fighting Drugs Might Also Stop Malaria Early
A number of compounds have been identified which could be used to fight malaria.
Collaboration Leads to Possible Shortcut to New Drugs
The reaction, reported in Science, demonstrates how a carboxylic acid can be transformed into a very reactive site through use of a novel photoredox catalyst.
Catalysts That Mimic Enzymes Could Revolutionize Pharmaceutical Manufacturing
Structures made of polymer chains allow the catalysts to work in water.
Discovery of How Taxol Works Could Lead to Better Anticancer Drugs
The drug’s interference with the normal function of microtubules could help in designing better anticancer drugs.

Thermodynamics Guided Lead Discovery and Optimization
György M. Keseru, Head of Discovery Chemistry, Gedeon Richter, speaking at Medchem Europe 2011.

Enhancing Success Rates in Virtual Screening
Giulio Rastelli, Associate Professor in Medicinal Chemistry at the University of Modena, speaking at Medchem Europe 2011.

How to Obtain a Solid Track Record in Medicinal Chemistry Research Services
Bruno Giethlen, Chief Scientific Officer, Prestwick Chemicals speaking at Pharma Outsourcing Congress 2011

Cationic Lipid Formulations with Programmed Biodegradability for Gene Therapy Applications
Asier Unciti-Broceta, Senior Research Fellow, University of Edinburgh, speaking at MedChem Europe

Novel Histamine Receptor Family Antagonists by Fragment Screening and Molecular Modelling
Mark Slack, Group Leader Cellular Assays, Evotec, speaking at MedChem Europe

The Development of Synthetic Approaches that Allow the Systematic Exploration of Chemical Space
Adam Nelson, Professor, University of Leeds, speaking at MedChem Europe

Next-Generation Kinase Inhibitors following a Retro-Design Approach
Gerhard Mueller, Chief Scientific Officer, Proteros Fragments, speaking at MedChem Europe

Beyond Growing and Linking - Impact of Fragments on the Discovery of Kinase Inhibitors
Andreas Kuglstatter, Research Scientist II, Hoffmann-La Roche, speaking at MedChem Europe

A Novel Platform Technology Sheds Light on the Molecular Mechanisms of Liver Toxicity of Two Parkinson Drugs
Friedrich Kroll, Head of Medicinal Chemistry, Caprotec, speaking at MedChem Europe

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