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Scientific News
Animal Testing can Mislead Drug Discovery and Development
Several blockbuster drugs would not be on the market, if scientists had relied solely on drug-uptake in animal trials, according to new research.
Synthesis and Bioactivity of Analogues of Tropodithietic Acid
The study suggests that the sulfur atoms in the marine antibiotic TDA are not essential for bioactivity, but different modes of action for TDA and its sulfur-free analogue cannot be excluded.
Cancer-Fighting Drugs Might Also Stop Malaria Early
A number of compounds have been identified which could be used to fight malaria.
Collaboration Leads to Possible Shortcut to New Drugs
The reaction, reported in Science, demonstrates how a carboxylic acid can be transformed into a very reactive site through use of a novel photoredox catalyst.
Catalysts That Mimic Enzymes Could Revolutionize Pharmaceutical Manufacturing
Structures made of polymer chains allow the catalysts to work in water.
Discovery of How Taxol Works Could Lead to Better Anticancer Drugs
The drug’s interference with the normal function of microtubules could help in designing better anticancer drugs.
Chemists Discover Cancer Drug Candidate Structure
Chemists at The Scripps Research Institute have determined the correct structure of a highly promising anticancer compound approved by the U.S. FDA for clinical trials in cancer patients.
Novel Drug Targets for Allergy Identified
Researchers have identified several target molecules which are suitable for the development of new allergy drugs.
Drug Does Not Improve Set of Cardiovascular Outcomes for Diastolic Heart Failure
NIH-supported study finds drug does appear to reduce hospitalizations for diastolic heart failure.
Entirely Novel Strategy to Molecular Anticancer Therapy Tricks Malignant Cells
New drug prevents tumour growth by inhibiting the nucleotide sanitizing enzyme MTH1.

Chemogenomic Strategies to Expand the Bioactive Chemical Space
Edgar Jacoby, Group Leader, Novartis, speaking at MedChem Europe

Dynamic Combinatorial Library – an Integrated Approach for Direct Lead Discovery Using Chemical Fragments
Beining Chen, Senior Lecturer, University of Sheffield, speaking at MedChem Europe

Dynamic Combinatorial Library – an Integrated Approach for Direct Lead Discovery Using Chemical Fragments
Beining Chen, Senior Lecturer, University of Sheffield, speaking at MedChem Europe

Chemical Synthesis and Rapid Scale-Up in Continuous Flow Reactors
Paul Watts, Senior Lecturer, University of Hull, speaking at Advances in Synthetic Chemistry

Supported Organic, Nanometallic and Enzymatic Catalysis in Microreactors
Willem Verboom, Associate professor, Univ. of Twente, speaking at Advances in Synthetic Chemistry

Microwave-assisted Multi-component Syntheses of Heterocycles Initiated by Transition Metal Catalysis
Thomas J. J. Müller, Chair of Organic Chemistry, Heinrich-Heine-Universität Düsseldorf, speaking at Advances in Synthetic Chemistry

Scaling Out an SNAr Reaction in Microwave Flow Reactors
Jonathan Moseley, Associate Principal Scientist, AstraZeneca, speaking at Advances in Synthetic Chemistry

Novel Process Windows - Gateways to Sustainable and Intensified Process Chemistry
Volker Hessel, Professor, Eindhoven University, speaking at Advances in Synthetic Chemistry

A Roadmap for Successful Probe Discovery in an Academic Setting: The KU Experience
Rathnam Chaguturu, University of Kansas, Director, speaking at Probe Discovery 2010.

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