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Scientific News
Misfolded Proteins Clump Together in a Surprising Place
Stowers researchers create new framework for protein aggregation under acute stress.
Nanoparticle Research Could Enhance Drug Delivery Through Skin
A milestone study from the University of Southampton could have major implications for the delivery of drugs.
Chemists Recruit Anthrax to Deliver Cancer Drugs
With some tinkering, a deadly protein becomes an efficient carrier for antibody drugs.
Protein ‘Map’ Could Lead to Potent New Cancer Drugs
Findings will help scientists to design drugs that could target NMT enzyme.
Animal Testing can Mislead Drug Discovery and Development
Several blockbuster drugs would not be on the market, if scientists had relied solely on drug-uptake in animal trials, according to new research.
Synthesis and Bioactivity of Analogues of Tropodithietic Acid
The study suggests that the sulfur atoms in the marine antibiotic TDA are not essential for bioactivity, but different modes of action for TDA and its sulfur-free analogue cannot be excluded.
Cancer-Fighting Drugs Might Also Stop Malaria Early
A number of compounds have been identified which could be used to fight malaria.
Collaboration Leads to Possible Shortcut to New Drugs
The reaction, reported in Science, demonstrates how a carboxylic acid can be transformed into a very reactive site through use of a novel photoredox catalyst.
Catalysts That Mimic Enzymes Could Revolutionize Pharmaceutical Manufacturing
Structures made of polymer chains allow the catalysts to work in water.
Discovery of How Taxol Works Could Lead to Better Anticancer Drugs
The drug’s interference with the normal function of microtubules could help in designing better anticancer drugs.

Kinase Inhibitors with Tailored Binding Kinetics by Fragment-Based Design
Peter Sennhenn, Head of Medicinal Chemistry, Proteros fragments GmbH, speaking at MedChem Europe 2009

Development of Proteomics Methods for Profiling Cytochrome P450s
Chris Sutton, Head of the ICT Proteomics and Mass Spectrometry Facility, Bradford University, speaking at ADMET Europe 2009

Screening for Transient Drugs/Fragments: New Opportunities for Drug Discovery
Sten Ohlson, Professor, University of Kalmar, speaking at MedChem Europe 2009

Structural Insights into Antagonist-K+ Channel Interactions
Olaf Pongs, Professor, Hamberg University, Screening Europe 2009

Filling in the Gaps of Early Drug Discovery with High-Throughput Label-Free Biosensors: Hope, Hype or Truth?
Julio Jose Martin, Manager Screening and Compound Profiling, GlaxoSmithKline, Screening Europe 2009

A Structural View on Protein Kinase CK2 and its Potential Role as a Target for Small Molecules
Karsten Niefind, University of Cologne, speaking at Screening Europe 2009

Fragment Based Drug Discovery of Novel MK2 Inhibitors
Thomas Hesterkamp, VP Fragment Based Drug Discovery, Evotec AG, speaking at MedChem Europe 2009

Development of DIBENZOSUBERONES as Potent and Highly Selective p38 MAPK Inhibitors
Stefan Laufer, Professor, Department Head, Eberhard-Karls-University Tuebingen, speaking at MedChem Europe 2009

Impedance-Based Measurement of GPCR Modulators in Drug Discovery – Characterization of Signalling Pathways in Recombinant and Non-Recombinant Cells
John Gatfield, Senior Lab Head Molecular Biology, Actelion Pharmaceuticals Ltd, speaking at Screening Europe 2009

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