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Scientific News
Animal Testing can Mislead Drug Discovery and Development
Several blockbuster drugs would not be on the market, if scientists had relied solely on drug-uptake in animal trials, according to new research.
Synthesis and Bioactivity of Analogues of Tropodithietic Acid
The study suggests that the sulfur atoms in the marine antibiotic TDA are not essential for bioactivity, but different modes of action for TDA and its sulfur-free analogue cannot be excluded.
Cancer-Fighting Drugs Might Also Stop Malaria Early
A number of compounds have been identified which could be used to fight malaria.
Collaboration Leads to Possible Shortcut to New Drugs
The reaction, reported in Science, demonstrates how a carboxylic acid can be transformed into a very reactive site through use of a novel photoredox catalyst.
Catalysts That Mimic Enzymes Could Revolutionize Pharmaceutical Manufacturing
Structures made of polymer chains allow the catalysts to work in water.
Discovery of How Taxol Works Could Lead to Better Anticancer Drugs
The drug’s interference with the normal function of microtubules could help in designing better anticancer drugs.
Chemists Discover Cancer Drug Candidate Structure
Chemists at The Scripps Research Institute have determined the correct structure of a highly promising anticancer compound approved by the U.S. FDA for clinical trials in cancer patients.
Novel Drug Targets for Allergy Identified
Researchers have identified several target molecules which are suitable for the development of new allergy drugs.
Drug Does Not Improve Set of Cardiovascular Outcomes for Diastolic Heart Failure
NIH-supported study finds drug does appear to reduce hospitalizations for diastolic heart failure.
Entirely Novel Strategy to Molecular Anticancer Therapy Tricks Malignant Cells
New drug prevents tumour growth by inhibiting the nucleotide sanitizing enzyme MTH1.

De Novo Molecular Design: A Powerful Strategy for the Discovery of New Potential Antimalarials and Antibacterials
Colin Fishwick, Reader/ Director Organic Chemistry/Leeds Structure-Based Drug Design Group, University of Leeds School of Chemistry, speaking at MedChem Europe 2009

Intersecting Biological and Chemical Knowledge for Computational Toxicology
Florian Nigsch, Research Associate, University of Cambridge, speaking at ADMET Europe 2009

CYP Poor Metaboliser Genotyping on the Agilent Bioanalyzer and Clinical Application
Irina Piatkov, Senior Hospital Scientist, Diversity Health Institute, speaking at the Molecular Diagnostics World Congress 2009

Biomarkers as Expression Signatures: Combinatorial Problem Solved with Gene Networks
Audrey Alexenko, Researcher, Stockholm Bioinformatics Centre, speaking at the Molecular Diagnostics World Congress 2009

Bioluminescent Cytochrome P450 Inhibition and Induction Assays: Comparisons to Conventional Methods
Jim Cali, Senior Scientist, Promega, speaking at ADMET Europe 2009

In silico Prediction of ADMET Properties
John Dearden, School of Pharmacy and Chemistry, Liverpool John Moores University, speaking as ADMET Europe 2009

Retigabine and Therapeutic Indications of Activating Neuronal KCNQ Voltage-Gated Potassium Ion Channels
Jim Wu, Head of Discovery Biology, Roche R&D Center, speaking at Ion Channel Targets 2008

Hypertension in P2Y2 Receptor-Deficient Mice is Caused by Constitutive Activation of ENaC
James Stockand, Associate Professor, University of Texas Health Science Center at Houston, speaking at Ion Channel Targets 2008

Mechanosensitivity, A Wide Open Field
Frederick Sachs, Distinguished Professor, New York State University at Buffalo, speaking at Ion Channel Targets 2008

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