Thursday, May 17, 2012
Technology Networks
Technology Networks
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 | Metabolic Profiling of Physiological and Pathological Processes Professor Elaine Holmes, Metabometrix, speaking at Advances in Metabolomic Profiling 2011. |
 | Lipidomics in Life Style Associated Diseases Ivana Bobeldijk-Pastorova, TNO, speaking at Advances in Metabolic Profiling 2011. |
Biomarkers Market (Discovery Technologies, Applications & Indications) – Global Trends, Opportunities & Forecasts (2011 – 2020)
MarketsandMarkets
This Biomarkers Market research report categorizes on the basis of discovery technologies and application market across major indications; forecasting revenues and analyzing trends.
Single Cell Omics 2011
Select Biosciences Ltd
The single cell Omics revolution is the potential transformation of cellular heterogeneity from a source of noise to a source of new, as yet hidden discoveries.
Multiplexed Diagnostics 2010
Select Biosciences Ltd
The multiplexed diagnostics market has grown rapidly and generated sales of approximately $2.4 billon in 2009, but is now balanced on multiple tipping points.
Genomics, Proteomics and Metabolomics in Diagnostics: Market landscape, innovative technologies and future outlook
Business Insights
There has been a significant transition in the diagnostic techniques created with increasing technological innovations. In the future, the focus will be on genetic study and disease predisposition, which will test patients' probability of acquiring a disease or a disorder, enabling precautionary steps.
MarketsandMarkets
This Biomarkers Market research report categorizes on the basis of discovery technologies and application market across major indications; forecasting revenues and analyzing trends.
Single Cell Omics 2011
Select Biosciences Ltd
The single cell Omics revolution is the potential transformation of cellular heterogeneity from a source of noise to a source of new, as yet hidden discoveries.
Multiplexed Diagnostics 2010
Select Biosciences Ltd
The multiplexed diagnostics market has grown rapidly and generated sales of approximately $2.4 billon in 2009, but is now balanced on multiple tipping points.
Genomics, Proteomics and Metabolomics in Diagnostics: Market landscape, innovative technologies and future outlook
Business Insights
There has been a significant transition in the diagnostic techniques created with increasing technological innovations. In the future, the focus will be on genetic study and disease predisposition, which will test patients' probability of acquiring a disease or a disorder, enabling precautionary steps.
Functional Metabolomics Reveals Novel Active Products in the DHA Metabolome
In this review, researchers from Harvard Medical School provide an update and overview of functional metabolomics that identified a new bioactive metabolome of docosahexaenoic acid.
Lipidomics of Intact Mitochondria by MALDI-TOF/MS
Researchers from University of Bari Aldo Moro describe a simple and fast method of lipid analyses of isolated intact mitochondria by means of MALDI-TOF mass spectrometry.
Warwick Researchers Solve 40-year-old Fourier Transform Mass Spectrometry Phasing Problem
Scientists at the University of Warwick have developed a computation which simultaneously doubles the resolution, sensitivity and mass accuracy of Fourier Transform Mass Spectrometry at no extra cost.
A Toxic Menu
Marine worm feeds on carbon monoxide and hydrogen sulphide with the help of symbiotic bacteria.
1H NMR Metabolomics Analysis of Glioblastoma Subtypes
In this study, researchers from the National Research Council, Canada investigate the correlation between the metabolomics and gene expression characteristics of glioblastoma multiformes.
Flexibility of a Eukaryotic Lipidome - Insights from Yeast Lipidomics
In this article, researchers from Max Planck Institute of Molecular Cell Biology and Genetics investigate the influence of a variety of commonly used growth conditions on the yeast lipidome.
Development of Quantitative Metabolomics for Pichia Pastoris
Five different procedures based on cold methanol quenching and cell separation by filtration were tested regarding methanol content and temperature of the quenching solution as key parameters.
Bioinformatics Tools for Mass Spectroscopy-Based Metabolomic Data Processing and Analysis
This paper provides an overview of the data processing tools available, offering a review of the collection of recent reports on the topic.
Detailed Mitochondrial Phenotyping by High Resolution Metabolomics
In this study, researchers from Emory University, have used “top-down” metabolic profiling to determine the spectrum of metabolites present in liver mitochondria.
Microbial Metabolomics
This review focuses on metabolomics in microorganisms and utilizes selected topics to illustrate its impact on the understanding of systems microbiology.
In this review, researchers from Harvard Medical School provide an update and overview of functional metabolomics that identified a new bioactive metabolome of docosahexaenoic acid.
Lipidomics of Intact Mitochondria by MALDI-TOF/MS
Researchers from University of Bari Aldo Moro describe a simple and fast method of lipid analyses of isolated intact mitochondria by means of MALDI-TOF mass spectrometry.
Warwick Researchers Solve 40-year-old Fourier Transform Mass Spectrometry Phasing Problem
Scientists at the University of Warwick have developed a computation which simultaneously doubles the resolution, sensitivity and mass accuracy of Fourier Transform Mass Spectrometry at no extra cost.
A Toxic Menu
Marine worm feeds on carbon monoxide and hydrogen sulphide with the help of symbiotic bacteria.
1H NMR Metabolomics Analysis of Glioblastoma Subtypes
In this study, researchers from the National Research Council, Canada investigate the correlation between the metabolomics and gene expression characteristics of glioblastoma multiformes.
Flexibility of a Eukaryotic Lipidome - Insights from Yeast Lipidomics
In this article, researchers from Max Planck Institute of Molecular Cell Biology and Genetics investigate the influence of a variety of commonly used growth conditions on the yeast lipidome.
Development of Quantitative Metabolomics for Pichia Pastoris
Five different procedures based on cold methanol quenching and cell separation by filtration were tested regarding methanol content and temperature of the quenching solution as key parameters.
Bioinformatics Tools for Mass Spectroscopy-Based Metabolomic Data Processing and Analysis
This paper provides an overview of the data processing tools available, offering a review of the collection of recent reports on the topic.
Detailed Mitochondrial Phenotyping by High Resolution Metabolomics
In this study, researchers from Emory University, have used “top-down” metabolic profiling to determine the spectrum of metabolites present in liver mitochondria.
Microbial Metabolomics
This review focuses on metabolomics in microorganisms and utilizes selected topics to illustrate its impact on the understanding of systems microbiology.
Agios Strengthens Team with Key Appointments and Promotion
The appointments include Robert J. DeVita, Ph.D., to the role of vice president of chemistry and Marion Dorsch, Ph.D., to the role of vice president of biology.
Metabolon’s Shanghai Jiao Tong University Lab Receives Validation
The joint metabolomics laboratory passed the quality control processes and has officially started operation.
BIOCRATES Goes Spain and Turkey
Austrian diagnostic expert in personalized medicine continues to expand its European distribution network.
Takeda and Metabolon Initiate Research Collaboration
Multiyear research alliance to discover novel targets and biomarkers.
LNC Closes Successfully its Second Fundraising
€ 3.5 million round to accelerate R & D and market access.
AB SCIEX Announces Academic Partnership Program
The program aims to increase the number of scientists who benefit from the company’s assistance and resources for advancing research in proteomics, metabolomics and lipidomics.
Metabolon Awarded Analytical Methods Patent
The patented method enables the researcher to process, analyze and interpret data more efficiently.
AB SCIEX Announces Academic Partnership Program to Support Biological Research
Focus on proteomics, metabolomics and lipidomics to accelerate promising work in science and biomedical studies.
Agilent Technologies and FAPESP Announce Support for Life Science Research Projects
The projects will support research in metabolomics and integrated biology of plants and bacteria at University of São Paulo and State University of Campinas.
AB SCIEX Expands Commercial Operations in Brazil
The expansion will support the increasing use of mass spectrometry for food safety testing, environmental analysis, academic research, drug development, forensic toxicology and clinical research.
The appointments include Robert J. DeVita, Ph.D., to the role of vice president of chemistry and Marion Dorsch, Ph.D., to the role of vice president of biology.
Metabolon’s Shanghai Jiao Tong University Lab Receives Validation
The joint metabolomics laboratory passed the quality control processes and has officially started operation.
BIOCRATES Goes Spain and Turkey
Austrian diagnostic expert in personalized medicine continues to expand its European distribution network.
Takeda and Metabolon Initiate Research Collaboration
Multiyear research alliance to discover novel targets and biomarkers.
LNC Closes Successfully its Second Fundraising
€ 3.5 million round to accelerate R & D and market access.
AB SCIEX Announces Academic Partnership Program
The program aims to increase the number of scientists who benefit from the company’s assistance and resources for advancing research in proteomics, metabolomics and lipidomics.
Metabolon Awarded Analytical Methods Patent
The patented method enables the researcher to process, analyze and interpret data more efficiently.
AB SCIEX Announces Academic Partnership Program to Support Biological Research
Focus on proteomics, metabolomics and lipidomics to accelerate promising work in science and biomedical studies.
Agilent Technologies and FAPESP Announce Support for Life Science Research Projects
The projects will support research in metabolomics and integrated biology of plants and bacteria at University of São Paulo and State University of Campinas.
AB SCIEX Expands Commercial Operations in Brazil
The expansion will support the increasing use of mass spectrometry for food safety testing, environmental analysis, academic research, drug development, forensic toxicology and clinical research.
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Transforming Analytical Data into Knowledge with Software for Metabolite Studies
ACD Labs
ACD/Labs has been developing specialized software for chemical and pharmaceutical research for over 16 years. Their expertise includes multi-technique, multi-instrument data handling, knowledge management of analytical and separations data, chemical drawing, and prediction software for a range of chemical properties as well as spectra and chromatograms.
QSAR Model of Regioselectivity of Metabolism in Human Liver Microsomes: Development, Validation, Comparison and Adaptation to Novel Compounds
ACD Labs
Analytical identification of metabolites for a drug candidate is usually a time consuming and low-throughput task which is performed only in late drug development phases. Therefore the ability to predict possible sites of human liver microsomal metabolism using in silico techniques would be highly beneficial for any medicinal chemist.
In silico Identification of Metabolic Soft Spots: Case Study Using ACD/ADME Suite Software
ACD Labs
Metabolic stability, determined in liver microsomes, is one of the primary assays used in early drug discovery. A key factor limiting compound half-life is the cytochrome P450 mediated metabolism. High clearance by these enzymes implies a higher and more frequent dosing as well as poses a risk for individual variations in exposure.
Analytical and Chemical Knowledge Management Software for Drug Metabolism Science
ACD Labs
Characterizing metabolite structures and metabolic pathways is essential to understanding the potential biological implications of compounds in drug discovery.
Analytical and Chemical Knowledge Management Software for Drug Metabolism Science
ACD Labs
Characterizing metabolite structures and metabolic pathways is essential to understanding the potential biological implications of compounds in drug discovery.
Development and Validation of a Novel Post-Thaw Recovery Media for Human Cryopreserved Hepatocytes
BD Biosciences
BD Biosciences has developed and validated a new post-thaw recovery medium for human cryopreserved hepatocytes. The recovery medium maintains hepatocyte post-thaw functions while improving cell health and recovery. The newly developed recovery medium was optimized with BD Gentest™ human inducible cryohepatocytes for viability and recovery.
Probabilistic Predictive Model of the Human Liver Microsomal Metabolism Regioselectivity
ACD Labs
Analytical identification of metabolites for a drug candidate is usually a time consuming and low-throughput task which is performed only in late drug development phases.Therefore, the ability to predict possible sites of human liver microsomal metabolism using in silico techniques would be highly beneficial for any medicinal chemist.
Fully Automated LC-MS/MS-based Determination of Bosentanand its Metabolites in Dried Blood Spots using the SCAP™ DBS System
Inovalab
Dried Blood Spot (DBS) analysis is a very promising alternative to conventional whole blood and plasma analysis used in drug discovery and development or later in therapeutic drug monitoring with well documented advantages.
AN INTEGRATED 1H NMR, GC-MS AND HPLC-(ESI/TOF) BASED METABOLOMICS APPROACH TO THE STUDY OF ACUTE EXERCISE IN HUMAN SERUM METABOLOME
There is an increasing concern about the different response and effect that acute exercise induces on diabetic people and a novel insight into this effect can be performed using a metabolomic approach. Metabolomic is becoming widely spread used as a new and powerful tool for discerning significant changes at metabolic level. In this study we aimed to perform a non-targeted analysis and to identify metabolic differences arisen after 30 minutes of acute exercise in both young men suffering from Ty
Nucleic Acid Reagents and Experimental Results in the NCBI Probe Database
National Center for Biotechnology Information, NIH, Bethesda, MD
Five years ago, the NCBI Probe database (ProbeDB) was established to provide a centralized archive of molecular probes used in biomedical applications. Currently ProbeDB contains around 10 million probes of 65 types including gene silencing agents, in situ hybridization probes, and probes for variation analysis and genome mapping. Presently, ProbeDB is the largest and most extensive database of this type available in public domain.
ACD Labs
ACD/Labs has been developing specialized software for chemical and pharmaceutical research for over 16 years. Their expertise includes multi-technique, multi-instrument data handling, knowledge management of analytical and separations data, chemical drawing, and prediction software for a range of chemical properties as well as spectra and chromatograms.
QSAR Model of Regioselectivity of Metabolism in Human Liver Microsomes: Development, Validation, Comparison and Adaptation to Novel Compounds
ACD Labs
Analytical identification of metabolites for a drug candidate is usually a time consuming and low-throughput task which is performed only in late drug development phases. Therefore the ability to predict possible sites of human liver microsomal metabolism using in silico techniques would be highly beneficial for any medicinal chemist.
In silico Identification of Metabolic Soft Spots: Case Study Using ACD/ADME Suite Software
ACD Labs
Metabolic stability, determined in liver microsomes, is one of the primary assays used in early drug discovery. A key factor limiting compound half-life is the cytochrome P450 mediated metabolism. High clearance by these enzymes implies a higher and more frequent dosing as well as poses a risk for individual variations in exposure.
Analytical and Chemical Knowledge Management Software for Drug Metabolism Science
ACD Labs
Characterizing metabolite structures and metabolic pathways is essential to understanding the potential biological implications of compounds in drug discovery.
Analytical and Chemical Knowledge Management Software for Drug Metabolism Science
ACD Labs
Characterizing metabolite structures and metabolic pathways is essential to understanding the potential biological implications of compounds in drug discovery.
Development and Validation of a Novel Post-Thaw Recovery Media for Human Cryopreserved Hepatocytes
BD Biosciences
BD Biosciences has developed and validated a new post-thaw recovery medium for human cryopreserved hepatocytes. The recovery medium maintains hepatocyte post-thaw functions while improving cell health and recovery. The newly developed recovery medium was optimized with BD Gentest™ human inducible cryohepatocytes for viability and recovery.
Probabilistic Predictive Model of the Human Liver Microsomal Metabolism Regioselectivity
ACD Labs
Analytical identification of metabolites for a drug candidate is usually a time consuming and low-throughput task which is performed only in late drug development phases.Therefore, the ability to predict possible sites of human liver microsomal metabolism using in silico techniques would be highly beneficial for any medicinal chemist.
Fully Automated LC-MS/MS-based Determination of Bosentanand its Metabolites in Dried Blood Spots using the SCAP™ DBS System
Inovalab
Dried Blood Spot (DBS) analysis is a very promising alternative to conventional whole blood and plasma analysis used in drug discovery and development or later in therapeutic drug monitoring with well documented advantages.
AN INTEGRATED 1H NMR, GC-MS AND HPLC-(ESI/TOF) BASED METABOLOMICS APPROACH TO THE STUDY OF ACUTE EXERCISE IN HUMAN SERUM METABOLOME
There is an increasing concern about the different response and effect that acute exercise induces on diabetic people and a novel insight into this effect can be performed using a metabolomic approach. Metabolomic is becoming widely spread used as a new and powerful tool for discerning significant changes at metabolic level. In this study we aimed to perform a non-targeted analysis and to identify metabolic differences arisen after 30 minutes of acute exercise in both young men suffering from Ty
Nucleic Acid Reagents and Experimental Results in the NCBI Probe Database
National Center for Biotechnology Information, NIH, Bethesda, MD
Five years ago, the NCBI Probe database (ProbeDB) was established to provide a centralized archive of molecular probes used in biomedical applications. Currently ProbeDB contains around 10 million probes of 65 types including gene silencing agents, in situ hybridization probes, and probes for variation analysis and genome mapping. Presently, ProbeDB is the largest and most extensive database of this type available in public domain.
Quantitative Determination of Total Bile Acids with a Thermo Scientific Varioskan Flash Multimode Reader Using a Kinetic Enzyme Cycling Assay
Thermo Fisher Scientific
Serum total bile acids (TBA) level is a long-established and accepted indicator of liver diseases. This application note presents a simple photometric measurement of serum TBA.
Optimization of Instrument Settings and Measurement Parameters for Kinetic Fluorometric and Luminometric Assays
Thermo Fisher Scientific
When fluorometric and luminometric assays are performed in microplate format, a high number of samples can be analyzed at a time. The speed of the reaction kinetics of the assay determines the requirements for the detection instrument and measurement parameters for achieving the best possible performance of the assay.
Pipetting performance of Thermo Scientific Finnpipette F2 in combination with Thermo Scientific Finntip Flex
Thermo Fisher Scientific
The Finnpipette® F2 product family has been designed by taking into account the demands of today´s laboratory work and the require¬ments of the end users. It offers superior comfort, performance, reliability and repeatability in one of the lightest pipettes available.
Using a Thermo Scientific Microplate Photometer to Choose an Optimum Reagent for Cytotoxicity Assays
Thermo Fisher Scientific
A number of different reagents can be used to perform photometric cell proliferation and viability assays. A microplate photometer can quickly determine which reagent is the best choice for an assay and then optimize the assay. Significant time savings and productivity gains can be achieved with this tool.
Ergonomics and Usability Study of Thermo Scientific Finnpipette F1 and F2 Pipettes
Thermo Fisher Scientific
The objective of the study was to evaluate the ergonomics and usability of six manual, singlechannel pipettes. This was done by measuring the load and strain symptoms exhibited by workers’ muscles and joints, and evaluating the usability features of pipettes in a simulated work situation.
Promega’s ADP-Glo™ Kinase Assay performed on BMG LABTECH’s PHERAstar FS and POLARstar Omega
BMG Labtech
The PHERAstar FS as well as the POLARstar Omega offer the ability to perform the ADP-Glo™ assay from Promega in a 384-well format. The ADP-Glo™ Kinase Assay is a homogenous luminescent assay to detect ADP in concentrations ranging from 1 mM to 0.01 µM. Instrument settings and standard ATP/ADP curves over a wide concentration range are presented for both the PHERAstar FS and the POLARstar Omega.
RADAR, a Xevo TQ-S function, combined with Low-High pH UPLC Screening for Fast, Simple Bioanalysis Methods Development
Waters Corporation
Here, we demonstrate the productivity gains possible with Xevo TQ-S for use in bioanalytical methods. Xevo TQ-S employs a unique RADAR functionality to collect data in the time scale of a narrow 1- to 2-second peak.
The Transcreener® ADP2 FI Assay performed on PHERAstar and Omega microplate readers
BMG LABTECH
alamarBlue® Assay for Assessment of Cell Proliferation using the FLUOstar OPTIMA
BMG LABTECH
A DELFIA® time-resolved fluorescence cell-mediated cytotoxicity assay performed on the PHERAstar
BMG LABTECH
Thermo Fisher Scientific
Serum total bile acids (TBA) level is a long-established and accepted indicator of liver diseases. This application note presents a simple photometric measurement of serum TBA.
Optimization of Instrument Settings and Measurement Parameters for Kinetic Fluorometric and Luminometric Assays
Thermo Fisher Scientific
When fluorometric and luminometric assays are performed in microplate format, a high number of samples can be analyzed at a time. The speed of the reaction kinetics of the assay determines the requirements for the detection instrument and measurement parameters for achieving the best possible performance of the assay.
Pipetting performance of Thermo Scientific Finnpipette F2 in combination with Thermo Scientific Finntip Flex
Thermo Fisher Scientific
The Finnpipette® F2 product family has been designed by taking into account the demands of today´s laboratory work and the require¬ments of the end users. It offers superior comfort, performance, reliability and repeatability in one of the lightest pipettes available.
Using a Thermo Scientific Microplate Photometer to Choose an Optimum Reagent for Cytotoxicity Assays
Thermo Fisher Scientific
A number of different reagents can be used to perform photometric cell proliferation and viability assays. A microplate photometer can quickly determine which reagent is the best choice for an assay and then optimize the assay. Significant time savings and productivity gains can be achieved with this tool.
Ergonomics and Usability Study of Thermo Scientific Finnpipette F1 and F2 Pipettes
Thermo Fisher Scientific
The objective of the study was to evaluate the ergonomics and usability of six manual, singlechannel pipettes. This was done by measuring the load and strain symptoms exhibited by workers’ muscles and joints, and evaluating the usability features of pipettes in a simulated work situation.
Promega’s ADP-Glo™ Kinase Assay performed on BMG LABTECH’s PHERAstar FS and POLARstar Omega
BMG Labtech
The PHERAstar FS as well as the POLARstar Omega offer the ability to perform the ADP-Glo™ assay from Promega in a 384-well format. The ADP-Glo™ Kinase Assay is a homogenous luminescent assay to detect ADP in concentrations ranging from 1 mM to 0.01 µM. Instrument settings and standard ATP/ADP curves over a wide concentration range are presented for both the PHERAstar FS and the POLARstar Omega.
RADAR, a Xevo TQ-S function, combined with Low-High pH UPLC Screening for Fast, Simple Bioanalysis Methods Development
Waters Corporation
Here, we demonstrate the productivity gains possible with Xevo TQ-S for use in bioanalytical methods. Xevo TQ-S employs a unique RADAR functionality to collect data in the time scale of a narrow 1- to 2-second peak.
The Transcreener® ADP2 FI Assay performed on PHERAstar and Omega microplate readers
BMG LABTECH
alamarBlue® Assay for Assessment of Cell Proliferation using the FLUOstar OPTIMA
BMG LABTECH
A DELFIA® time-resolved fluorescence cell-mediated cytotoxicity assay performed on the PHERAstar
BMG LABTECH
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