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Wednesday, July 30, 2014
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LabTube Meets Howard Kopech, Thermo Fish...
Insights from Metabolomics in Compartmen...LabTube Meets Dr Rohit Khanna, Waters...Advances in Volatile Analyses for Diseas...

Featured Products
Featured Product - XF Prep Station
XF Prep Station

Webcasts
Webcasts - TagLite® 2 cell assay - the next dimension to discovering new antibody drugsTagLite® 2 cell assay - the next dimension to discovering new antibody drugs
Sandra Grau-Richards, Senior Scientist/Team Leader Roche-Glycart
Webcasts - Advances in Volatile Analyses for Disease DiagnosisAdvances in Volatile Analyses for Disease Diagnosis
Norman Ratcliffe, University of the West of England, speaking at Advances in Biodetection & Biosensors 2014.

Market Reports
Analytical Instrument Market in the US 2014-2018
Infinity Research

TechNavio's report focuses on the US and has been prepared based on an in-depth market analysis with inputs from industry experts.
Molecular Spectroscopy Market by Technology & Application - Forecast to 2018
MarketsandMarkets

Over the years, the molecular spectroscopy market, comprising instruments, consumables, and services, has witnessed various technological advancements. These advancements have led to a growth in the number of molecular spectroscopy applications.
Mass Spectrometry Market by Technology & Application - Global Trends & Forecast to 2018
MarketsandMarkets

The global mass spectrometry market witnesses high competitive intensity as there are many big and small firms with similar product offerings. These companies adopt various strategies to increase their market shares and to establish a strong foothold in the global market.
Liposomes
RI Technologies

This market insight report on liposomes gives an insight into global liposomes market. The report provides market analytics by application, and by therapeutic area.
Metabolomics
RI Technologies

This report gives an insight into Metabolomics Technologies - Combined/Integrated Systems, Hardware Systems for metabolic analytics, and Software Systems. Estimations and predictions for the total global Metabolomics Technologies' market are given by geographic regions encompassing United States, Canada, Europe, Asia-Pacific, and Japan.
Bioinformatics
RI Technologies

This report gives a market insight into products and services used in the bioinformatics industry. The market is analyzed by product and applications; Database, Software and Hardware form the product categories, finding applications in Genomics, Proteomics, Metabolomics, and other (Drug Discovery, Cheminformatics, and Pharmacogenomics).
Biomarkers
RI Technologies

This report on focuses on the different types of biomarkers and their impact on various disease areas. The study also provides global market analysis for biomarkers by disease area and by prominent biomarker identification technologies.
Biomarkers in Drug Discovery - Integration in Early Stage Promotes Use of Companion Diagnostics to Optimize Therapeutic Outcomes
Global Data

The report describes the history of biomarkers and their role in fulfilling the unmet needs of the conventional drug discovery process. The drivers and barriers for the biomarkers market, along with the key issues faced in the application of biomarkers in the drug discovery process, are highlighted.
Life Science Software 2013: Markets and Opportunities
Biopharm Reports

This reports into in the life science field examines the use of specialist software and databases relating to the conduct of PCR, DNA sequencing, DNA microarray, flow cytometry, mass spectrometry and disease biomarker studies. The studies were carried out to assist software developers and vendors to identify market opportunities in these fields.
Life Science Consumables 2013: Markets and Opportunities
Biopharm Reports

Techniques such as PCR, DNA microarray, DNA sequencing, mass spectrometry and flow cytometry have grown significantly in the last decade and by 2015 markets for these five areas are expected to exceed $50 billion, globally. In these and related fields, consumables are generally the second or third largest area in cost terms, after instrumentation.
Scientific News
UT Southwestern Researchers Uncover New Brain Pathways
New therapies for treating Type 2 diabetes and obesity.
Mass Spec-Based Metabolomics Workflows to Evaluate Plant Immunity
This article reviews metabolomics studies used to evaluate plant immunity with an emphasis on mass spectrometry in its many forms.
Assessing Anticancer Drugs Efficacy by Amino Acid Metabolomics
Researchers aimed to develop a method that determines the therapeutic efficacy of anticancer drugs based on the changes in amino acid metabolism at the cellular level.
Time Of Day Crucial to Accurately Test for Diseases
A new study published in PNAS has found that time of day and sleep deprivation have a significant effect on our metabolism.
When Drugs Do More Harm Than Good for Type 2 Diabetes Patients
Harm to quality of life outweighs benefits of treatment for older patients and those with negative feelings about side effects.
Inflammation in Fat Tissue Helps Prevent Metabolic Disease
The findings were first published online June 12 in Cell Metabolism.
Evaluating Acute Hydrogen Sulfide Poisoning in Rats through Serum Metabolomics
Through the use of GC/MS-based metabolomics, researchers have evaluated the effect of acute hydrogen sulfide poisoning on the metabolic profiles of rats.
Pathway Between Gut and Liver Regulates Bone Mass
Researchers have uncovered a previously unknown biological process involving vitamin B12 and taurine that regulates the production of new bone cells.
Study Explains How Green Tea Could Reduce Pancreatic Cancer Risk
The study published in the journal, Metabolomics, offers an explanation that researchers say could open a new area of cancer-fighting research.
Fatty Liver Disease Prevented in Mice
Blocking a path that delivers dietary fructose to the liver prevented mice from developing the condition, according to investigators.
Business News
Developing Guidelines for the Application of ‘Omics’-Based Tests
The Australian National Health and Medical Research Council (NHMRC) has released Principles for the translation of ‘omics’-based tests from discovery to health care for public consultation.
IROA Technologies, University of Florida Announce Biomarker Collaboration
Company will support the University of Florida in a collaborative search for biomarkers of liver cancer and other liver diseases.
Metabolon, Geisinger Partner on Prediabetes Study
Metabolon will sponsor a pilot study to evaluate its Quantose IRTM test as a monitor of glycemic control in people with prediabetes.
ASMS 2014 Overview
We take a look at some of the major new product announcements from ASMS 2014.
Human Metabolome Technologies Hires VP, Business and Product Development
Dr. Alexander Buko has joined the executive team in a newly created position as Vice President of HMT America reporting to President Tsutotmu Hoshiba.
Canada Creating Genomics Innovation Network
Network will create a mechanism for cross-country collaboration, providing access to the highest quality genomic technologies and advice.
Thermo, Nuclea Biotechnologies Collaborate to Develop Diabetes Markers
Companies pooling their expertise to develop novel multiplexed research methods for high-throughput quantification of native insulin and its therapeutic analogs.
Salk Institute Receives $3M Gift for Ageing Research
The gift from the Glenn Foundation for Medical Research will allow the Institute to continue conducting research to understand the biology of normal human aging and age-related diseases.
Metabolon Enters into Collaboration with GSK
Agreement will see Metabolon provide metabolomic profiling services to GlaxoSmithKline.
Metabolon Debuts New Client Portal at Bio-IT World Expo
MetaboLync™ is a cloud-based solution for sharing, visualizing, and analyzing metabolomics data.

Events
Genetics and Genomics
20 Aug 2014
Genetics and Genomics ...
More information
Drug Metabolism & Discovery AD
11 Sep 2014
Drug Metabolism & Discovery AD ...
More information
Metabomeeting 2014
10 Sep 2014
Metabomeeting 2014 ...
More information
Clinical Applications of Mass
29 Oct 2014
Clinical Applications of Mass ...
More information

ePosters
Automatic Characterization of Lipids Using Charge Remote Fragmentation Ions and Peaks Characteristic of Fatty Acid Fragmentation From MALDI MS/MS Data
(1)PREMIER Biosoft, Indore, India; (2)PREMIER Biosoft, Palo Alto, U.S.A; (3)AB SCIEX, Darmstadt, Germany; (4)AB SCIEX, Framingham, U.S.A.

Automated identification of lipids using CRF ions and high energy MS/MS fragment ions and novel software.
Automatic Characterization of Lipids Using Charge Remote Fragmentation Ions and Peaks Characteristic of Fatty Acid Fragmentation From MALDI MS/MS Data
(1)PREMIER Biosoft, Indore, India; (2)PREMIER Biosoft, Palo Alto, U.S.A; (3)AB SCIEX, Darmstadt, Germany; (4)AB SCIEX, Framingham, U.S.A.

Automated identification of lipids using CRF ions and high energy MS/MS fragment ions and novel software.
Identification and classification of antifouling compounds secreted by anti MIC microorganisms. A metabolomic analysis.
University of Burgos, INBIOTEC, CSIC and ACCIONA Infraestructuras, Spain

BIOCORIN project, aims to develop a green alternative to the coatings and solutions used up to date for MIC corrosion control. Some of the results of this project are presented here, with the identification of several relevant antifouling compounds secreted by environmentally isolated anti-MIC strains of microorganisms via a metabolomic approach.
Rapid Identification of Microorganisms by Touch Spray and Paper Spray Ambient Ionization
Purdue University

The rapid and accurate identification of microorganisms is necessary in order to improve public health. Molecular-based identification allows for rapid patient treatment and provides more accurate diagnoses, two crucial aspects for successful treatment, yet a great challenge. In this work PS-MS, an existing ambient method, and TS-MS, a newly developed technique, are being utilized in the rapid discrimination of microorganisms (<2 min).
Molecular Dynamics Simulation Study of Pulmonary Surfactant Interacting With Nanoparticles
University of Karachi

MD simulation studies using NAMD of lipid bilayers supported on alpha-quartz (nanoparticles) and kaolinite with explicit water molecules will be presented to understand the physiochemical effects of nanoparticles on pulmonary surfactant.
Transforming Analytical Data into Knowledge with Software for Metabolite Studies
ACD Labs

ACD/Labs has been developing specialized software for chemical and pharmaceutical research for over 16 years. Their expertise includes multi-technique, multi-instrument data handling, knowledge management of analytical and separations data, chemical drawing, and prediction software for a range of chemical properties as well as spectra and chromatograms.
QSAR Model of Regioselectivity of Metabolism in Human Liver Microsomes: Development, Validation, Comparison and Adaptation to Novel Compounds
ACD Labs

Analytical identification of metabolites for a drug candidate is usually a time consuming and low-throughput task which is performed only in late drug development phases. Therefore the ability to predict possible sites of human liver microsomal metabolism using in silico techniques would be highly beneficial for any medicinal chemist.
In silico Identification of Metabolic Soft Spots: Case Study Using ACD/ADME Suite Software
ACD Labs

Metabolic stability, determined in liver microsomes, is one of the primary assays used in early drug discovery. A key factor limiting compound half-life is the cytochrome P450 mediated metabolism. High clearance by these enzymes implies a higher and more frequent dosing as well as poses a risk for individual variations in exposure.
Analytical and Chemical Knowledge Management Software for Drug Metabolism Science
ACD Labs

Characterizing metabolite structures and metabolic pathways is essential to understanding the potential biological implications of compounds in drug discovery.
Analytical and Chemical Knowledge Management Software for Drug Metabolism Science
ACD Labs

Characterizing metabolite structures and metabolic pathways is essential to understanding the potential biological implications of compounds in drug discovery.
Application Notes
Qualitative and Quantitative Characterization of the Metabolome, Lipidome, and Proteome of Human Hepatocytes Stably Transfected with Cytochrome P450 2E1 Using Data Independent LC/MS
Waters Corporation

Drug toxicity is a major reason for the failure of candidate pharmaceuticals during their development. Therefore, it is important to realize the potential for toxicity in a timely fashion. A label-free multi-omics approach has been applied for the analysis of the transfected human hepatocyte cells by implementing LC/HDMSE, providing both qualitative and quantitative information within a single experiment.
TransOmics Informatics Powered by Nonlinear Dynamics
Waters Corporation

This application note introduces the workflow of TransOmics Informatics Software that has been specifically developed for the larger scale analysis of ion mobility MS data from proteomics and metabolomics data sets, comprising technical and biological replicates.
Quantitative Determination of Total Bile Acids with a Thermo Scientific Varioskan Flash Multimode Reader Using a Kinetic Enzyme Cycling Assay
Thermo Fisher Scientific

Serum total bile acids (TBA) level is a long-established and accepted indicator of liver diseases. This application note presents a simple photometric measurement of serum TBA.
Optimization of Instrument Settings and Measurement Parameters for Kinetic Fluorometric and Luminometric Assays
Thermo Fisher Scientific

When fluorometric and luminometric assays are performed in microplate format, a high number of samples can be analyzed at a time. The speed of the reaction kinetics of the assay determines the requirements for the detection instrument and measurement parameters for achieving the best possible performance of the assay.
Pipetting performance of Thermo Scientific Finnpipette F2 in combination with Thermo Scientific Finntip Flex
Thermo Fisher Scientific

The Finnpipette® F2 product family has been designed by taking into account the demands of today´s laboratory work and the require¬ments of the end users. It offers superior comfort, performance, reliability and repeatability in one of the lightest pipettes available.
Using a Thermo Scientific Microplate Photometer to Choose an Optimum Reagent for Cytotoxicity Assays
Thermo Fisher Scientific

A number of different reagents can be used to perform photometric cell proliferation and viability assays. A microplate photometer can quickly determine which reagent is the best choice for an assay and then optimize the assay. Significant time savings and productivity gains can be achieved with this tool.
Ergonomics and Usability Study of Thermo Scientific Finnpipette F1 and F2 Pipettes
Thermo Fisher Scientific

The objective of the study was to evaluate the ergonomics and usability of six manual, singlechannel pipettes. This was done by measuring the load and strain symptoms exhibited by workers’ muscles and joints, and evaluating the usability features of pipettes in a simulated work situation.
Promega’s ADP-Glo™ Kinase Assay performed on BMG LABTECH’s PHERAstar FS and POLARstar Omega
BMG Labtech

The PHERAstar FS as well as the POLARstar Omega offer the ability to perform the ADP-Glo™ assay from Promega in a 384-well format. The ADP-Glo™ Kinase Assay is a homogenous luminescent assay to detect ADP in concentrations ranging from 1 mM to 0.01 µM. Instrument settings and standard ATP/ADP curves over a wide concentration range are presented for both the PHERAstar FS and the POLARstar Omega.
RADAR, a Xevo TQ-S function, combined with Low-High pH UPLC Screening for Fast, Simple Bioanalysis Methods Development
Waters Corporation

Here, we demonstrate the productivity gains possible with Xevo TQ-S for use in bioanalytical methods. Xevo TQ-S employs a unique RADAR functionality to collect data in the time scale of a narrow 1- to 2-second peak.
The Transcreener® ADP2 FI Assay performed on PHERAstar and Omega microplate readers
BMG LABTECH


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