Thursday, February 23, 2012
Technology Networks
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 | Antibody-Based Proteomics in Action: A Systematic Investigation of Candidate Breast Cancer Progression-Associated Biomarkers Identified from Omic Screens William Gallagher, Associate Professor, UCD Conway, speaking at European Biomarkers Summit 2011. |
 | A New View on Biomarkers in Personalized and Systems Medicine for Metabolic Diseases Ben Van Ommen, Senior Research Fellow, TNO, speaking at European Biomarkers Summit 2011. |
Biomarkers Market (Discovery Technologies, Applications & Indications) – Global Trends, Opportunities & Forecasts (2011 – 2020)
MarketsandMarkets
This Biomarkers Market research report categorizes on the basis of discovery technologies and application market across major indications; forecasting revenues and analyzing trends.
Single Cell Omics 2011
Select Biosciences Ltd
The single cell Omics revolution is the potential transformation of cellular heterogeneity from a source of noise to a source of new, as yet hidden discoveries.
Multiplexed Diagnostics 2010
Select Biosciences Ltd
The multiplexed diagnostics market has grown rapidly and generated sales of approximately $2.4 billon in 2009, but is now balanced on multiple tipping points.
Genomics, Proteomics and Metabolomics in Diagnostics: Market landscape, innovative technologies and future outlook
Business Insights
There has been a significant transition in the diagnostic techniques created with increasing technological innovations. In the future, the focus will be on genetic study and disease predisposition, which will test patients' probability of acquiring a disease or a disorder, enabling precautionary steps.
MarketsandMarkets
This Biomarkers Market research report categorizes on the basis of discovery technologies and application market across major indications; forecasting revenues and analyzing trends.
Single Cell Omics 2011
Select Biosciences Ltd
The single cell Omics revolution is the potential transformation of cellular heterogeneity from a source of noise to a source of new, as yet hidden discoveries.
Multiplexed Diagnostics 2010
Select Biosciences Ltd
The multiplexed diagnostics market has grown rapidly and generated sales of approximately $2.4 billon in 2009, but is now balanced on multiple tipping points.
Genomics, Proteomics and Metabolomics in Diagnostics: Market landscape, innovative technologies and future outlook
Business Insights
There has been a significant transition in the diagnostic techniques created with increasing technological innovations. In the future, the focus will be on genetic study and disease predisposition, which will test patients' probability of acquiring a disease or a disorder, enabling precautionary steps.
Launch of DIRECT - An Innovative Medicines Initiative Project for Personalized Medicine in Diabetes
Academia and the pharmaceutical industry working together in the fight against diabetes.
Lipidomics Reveals Multiple Pathway Effects of a Multi-Components Preparation on Lipid Biochemistry in ApoE*3Leiden.CETP Mice
The study illustrates the power of lipidomics in unraveling intervention effects in helping to find new targets or ingredients for lifestyle-related metabolic abnormality.
Recent Advances of Metabolomics in Plant Biotechnology
This article describes the basic analytical advancements in plant metabolomics and bioinformatics and the application of metabolomics to the biological study of plants.
Metabolic Regulation in Progression to Autoimmune Diabetes
The findings from VTT Technical Research Centre of Finland indicate that autoimmune diabetes is preceded by a state of increased metabolic demands on the islets resulting in elevated insulin secretion.
Discovery of Early-Stage Biomarkers for Diabetic Kidney Disease using MS-Based Metabolomics
This study demonstrates the potential of multivariate data analysis and metabolomics in the field of diabetic complications.
Identification of N-Acetyltaurine as a Novel Metabolite of Ethanol through Metabolomics-Guided Biochemical Analysis
Researchers from the University of Minnesota have investigated the influence of ethanol on small-molecule metabolome and the role of CYP2E1 in ethanol-induced hepatotoxicity using LC-MS based metabolomics platform and Cyp2e1-null mouse model.
Analyzing and Mapping Sweat Metabolomics by High-Resolution NMR Spectroscopy
Researchers from the Russian Academy of Sciences have utilized high-resolution to NMR to study and identify the content of human sweat.
Spherix Announces Successful Completion of Important Toxicology Study of SPX-106
The company reported the successful completion of its 28-day rat toxicology. Results demonstrated an ample margin of safety with the dosing planned for the first-in-human study.
Identification of a New Plasma Biomarker of Alzheimer Disease using Metabolomics Technology
This study by researchers from Eisai Co Ltd suggests that plasma desmosterol could be become a powerful new specific biomarker for the early and easy Alzheimers Disease diagnosis.
Metabolomics Study of Stepwise Hepatocarcinogenesis from the Model Rats to Patients: Potential Biomarkers Effective for Small Hepatocellular Carcinoma Diagnosis
Results from the study indicate that this metabolomics method has the potential of finding biomarkers for the early diagnosis of HCC.
Academia and the pharmaceutical industry working together in the fight against diabetes.
Lipidomics Reveals Multiple Pathway Effects of a Multi-Components Preparation on Lipid Biochemistry in ApoE*3Leiden.CETP Mice
The study illustrates the power of lipidomics in unraveling intervention effects in helping to find new targets or ingredients for lifestyle-related metabolic abnormality.
Recent Advances of Metabolomics in Plant Biotechnology
This article describes the basic analytical advancements in plant metabolomics and bioinformatics and the application of metabolomics to the biological study of plants.
Metabolic Regulation in Progression to Autoimmune Diabetes
The findings from VTT Technical Research Centre of Finland indicate that autoimmune diabetes is preceded by a state of increased metabolic demands on the islets resulting in elevated insulin secretion.
Discovery of Early-Stage Biomarkers for Diabetic Kidney Disease using MS-Based Metabolomics
This study demonstrates the potential of multivariate data analysis and metabolomics in the field of diabetic complications.
Identification of N-Acetyltaurine as a Novel Metabolite of Ethanol through Metabolomics-Guided Biochemical Analysis
Researchers from the University of Minnesota have investigated the influence of ethanol on small-molecule metabolome and the role of CYP2E1 in ethanol-induced hepatotoxicity using LC-MS based metabolomics platform and Cyp2e1-null mouse model.
Analyzing and Mapping Sweat Metabolomics by High-Resolution NMR Spectroscopy
Researchers from the Russian Academy of Sciences have utilized high-resolution to NMR to study and identify the content of human sweat.
Spherix Announces Successful Completion of Important Toxicology Study of SPX-106
The company reported the successful completion of its 28-day rat toxicology. Results demonstrated an ample margin of safety with the dosing planned for the first-in-human study.
Identification of a New Plasma Biomarker of Alzheimer Disease using Metabolomics Technology
This study by researchers from Eisai Co Ltd suggests that plasma desmosterol could be become a powerful new specific biomarker for the early and easy Alzheimers Disease diagnosis.
Metabolomics Study of Stepwise Hepatocarcinogenesis from the Model Rats to Patients: Potential Biomarkers Effective for Small Hepatocellular Carcinoma Diagnosis
Results from the study indicate that this metabolomics method has the potential of finding biomarkers for the early diagnosis of HCC.
Moffitt, Sanford-Burnham and Florida Hospital Create Personalized Medicine Partnership
The partnership will conduct collaborative research to accelerate discovery and to develop new treatments in the areas of cancer and metabolic diseases.
Prismic Pharmaceuticals Acquires Scarista's Exclusive License to Amarin's Omega-3 Patents
Company to develop, market, and out-license products based on a portfolio of issued U.S. and foreign composition, for the treatment of disorders of the central nervous system.
Thomson Mass Spectrometry Laboratory Selected as Waters Center of Innovation
Waters recognizes Prof. Marcos Eberlin for pioneering mass spectrometry.
Advion Appoints Chinese Distributor of its Compact Mass Spectrometer
Universal Analytical and Testing Instruments, Ltd. has been appointed as the exclusive distributor for the expression compact mass spectrometer.
Evotec and Harvard University Expand Strategic Alliance
This second strategic alliance is aimed at discovering and developing new biomarkers and treatments in the field of kidney disease.
Pacific Biomarkers Announces New Chief Scientific Officer
Pacific Biomarkers names the company's current Vice President, Research and Development, Amar A. Sethi, MD, PhD, as the new Chief Scientific Officer.
Metabolon Granted Patent for Determining Metabolic Age of an Individual
Metabolon, Inc. announces the grant of EP Patent 2,089,539B entitled, “Biomarkers Related to Metabolic Age and Methods Using the Same.”
LMU-DCOM Announces Metabolomics Program
New unit to define disease biomarkers and study disease mechanisms.
Agilent Supports Russell Thomas’ Research at the Hamner Institutes for Health Sciences
Russell supported for his work developing methods to predict drug-induced liver injury.
Agios Secures $78 Million in Oversubscribed Series C Financing
The proceeds will accelerate cancer metabolism programs and support expansion into new area of dysregulated metabolism.
The partnership will conduct collaborative research to accelerate discovery and to develop new treatments in the areas of cancer and metabolic diseases.
Prismic Pharmaceuticals Acquires Scarista's Exclusive License to Amarin's Omega-3 Patents
Company to develop, market, and out-license products based on a portfolio of issued U.S. and foreign composition, for the treatment of disorders of the central nervous system.
Thomson Mass Spectrometry Laboratory Selected as Waters Center of Innovation
Waters recognizes Prof. Marcos Eberlin for pioneering mass spectrometry.
Advion Appoints Chinese Distributor of its Compact Mass Spectrometer
Universal Analytical and Testing Instruments, Ltd. has been appointed as the exclusive distributor for the expression compact mass spectrometer.
Evotec and Harvard University Expand Strategic Alliance
This second strategic alliance is aimed at discovering and developing new biomarkers and treatments in the field of kidney disease.
Pacific Biomarkers Announces New Chief Scientific Officer
Pacific Biomarkers names the company's current Vice President, Research and Development, Amar A. Sethi, MD, PhD, as the new Chief Scientific Officer.
Metabolon Granted Patent for Determining Metabolic Age of an Individual
Metabolon, Inc. announces the grant of EP Patent 2,089,539B entitled, “Biomarkers Related to Metabolic Age and Methods Using the Same.”
LMU-DCOM Announces Metabolomics Program
New unit to define disease biomarkers and study disease mechanisms.
Agilent Supports Russell Thomas’ Research at the Hamner Institutes for Health Sciences
Russell supported for his work developing methods to predict drug-induced liver injury.
Agios Secures $78 Million in Oversubscribed Series C Financing
The proceeds will accelerate cancer metabolism programs and support expansion into new area of dysregulated metabolism.
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Transforming Analytical Data into Knowledge with Software for Metabolite Studies
ACD Labs
ACD/Labs has been developing specialized software for chemical and pharmaceutical research for over 16 years. Their expertise includes multi-technique, multi-instrument data handling, knowledge management of analytical and separations data, chemical drawing, and prediction software for a range of chemical properties as well as spectra and chromatograms.
QSAR Model of Regioselectivity of Metabolism in Human Liver Microsomes: Development, Validation, Comparison and Adaptation to Novel Compounds
ACD Labs
Analytical identification of metabolites for a drug candidate is usually a time consuming and low-throughput task which is performed only in late drug development phases. Therefore the ability to predict possible sites of human liver microsomal metabolism using in silico techniques would be highly beneficial for any medicinal chemist.
In silico Identification of Metabolic Soft Spots: Case Study Using ACD/ADME Suite Software
ACD Labs
Metabolic stability, determined in liver microsomes, is one of the primary assays used in early drug discovery. A key factor limiting compound half-life is the cytochrome P450 mediated metabolism. High clearance by these enzymes implies a higher and more frequent dosing as well as poses a risk for individual variations in exposure.
Analytical and Chemical Knowledge Management Software for Drug Metabolism Science
ACD Labs
Characterizing metabolite structures and metabolic pathways is essential to understanding the potential biological implications of compounds in drug discovery.
Analytical and Chemical Knowledge Management Software for Drug Metabolism Science
ACD Labs
Characterizing metabolite structures and metabolic pathways is essential to understanding the potential biological implications of compounds in drug discovery.
Development and Validation of a Novel Post-Thaw Recovery Media for Human Cryopreserved Hepatocytes
BD Biosciences
BD Biosciences has developed and validated a new post-thaw recovery medium for human cryopreserved hepatocytes. The recovery medium maintains hepatocyte post-thaw functions while improving cell health and recovery. The newly developed recovery medium was optimized with BD Gentest™ human inducible cryohepatocytes for viability and recovery.
Probabilistic Predictive Model of the Human Liver Microsomal Metabolism Regioselectivity
ACD Labs
Analytical identification of metabolites for a drug candidate is usually a time consuming and low-throughput task which is performed only in late drug development phases.Therefore, the ability to predict possible sites of human liver microsomal metabolism using in silico techniques would be highly beneficial for any medicinal chemist.
Fully Automated LC-MS/MS-based Determination of Bosentanand its Metabolites in Dried Blood Spots using the SCAP™ DBS System
Inovalab
Dried Blood Spot (DBS) analysis is a very promising alternative to conventional whole blood and plasma analysis used in drug discovery and development or later in therapeutic drug monitoring with well documented advantages.
AN INTEGRATED 1H NMR, GC-MS AND HPLC-(ESI/TOF) BASED METABOLOMICS APPROACH TO THE STUDY OF ACUTE EXERCISE IN HUMAN SERUM METABOLOME
There is an increasing concern about the different response and effect that acute exercise induces on diabetic people and a novel insight into this effect can be performed using a metabolomic approach. Metabolomic is becoming widely spread used as a new and powerful tool for discerning significant changes at metabolic level. In this study we aimed to perform a non-targeted analysis and to identify metabolic differences arisen after 30 minutes of acute exercise in both young men suffering from Ty
Nucleic Acid Reagents and Experimental Results in the NCBI Probe Database
National Center for Biotechnology Information, NIH, Bethesda, MD
Five years ago, the NCBI Probe database (ProbeDB) was established to provide a centralized archive of molecular probes used in biomedical applications. Currently ProbeDB contains around 10 million probes of 65 types including gene silencing agents, in situ hybridization probes, and probes for variation analysis and genome mapping. Presently, ProbeDB is the largest and most extensive database of this type available in public domain.
ACD Labs
ACD/Labs has been developing specialized software for chemical and pharmaceutical research for over 16 years. Their expertise includes multi-technique, multi-instrument data handling, knowledge management of analytical and separations data, chemical drawing, and prediction software for a range of chemical properties as well as spectra and chromatograms.
QSAR Model of Regioselectivity of Metabolism in Human Liver Microsomes: Development, Validation, Comparison and Adaptation to Novel Compounds
ACD Labs
Analytical identification of metabolites for a drug candidate is usually a time consuming and low-throughput task which is performed only in late drug development phases. Therefore the ability to predict possible sites of human liver microsomal metabolism using in silico techniques would be highly beneficial for any medicinal chemist.
In silico Identification of Metabolic Soft Spots: Case Study Using ACD/ADME Suite Software
ACD Labs
Metabolic stability, determined in liver microsomes, is one of the primary assays used in early drug discovery. A key factor limiting compound half-life is the cytochrome P450 mediated metabolism. High clearance by these enzymes implies a higher and more frequent dosing as well as poses a risk for individual variations in exposure.
Analytical and Chemical Knowledge Management Software for Drug Metabolism Science
ACD Labs
Characterizing metabolite structures and metabolic pathways is essential to understanding the potential biological implications of compounds in drug discovery.
Analytical and Chemical Knowledge Management Software for Drug Metabolism Science
ACD Labs
Characterizing metabolite structures and metabolic pathways is essential to understanding the potential biological implications of compounds in drug discovery.
Development and Validation of a Novel Post-Thaw Recovery Media for Human Cryopreserved Hepatocytes
BD Biosciences
BD Biosciences has developed and validated a new post-thaw recovery medium for human cryopreserved hepatocytes. The recovery medium maintains hepatocyte post-thaw functions while improving cell health and recovery. The newly developed recovery medium was optimized with BD Gentest™ human inducible cryohepatocytes for viability and recovery.
Probabilistic Predictive Model of the Human Liver Microsomal Metabolism Regioselectivity
ACD Labs
Analytical identification of metabolites for a drug candidate is usually a time consuming and low-throughput task which is performed only in late drug development phases.Therefore, the ability to predict possible sites of human liver microsomal metabolism using in silico techniques would be highly beneficial for any medicinal chemist.
Fully Automated LC-MS/MS-based Determination of Bosentanand its Metabolites in Dried Blood Spots using the SCAP™ DBS System
Inovalab
Dried Blood Spot (DBS) analysis is a very promising alternative to conventional whole blood and plasma analysis used in drug discovery and development or later in therapeutic drug monitoring with well documented advantages.
AN INTEGRATED 1H NMR, GC-MS AND HPLC-(ESI/TOF) BASED METABOLOMICS APPROACH TO THE STUDY OF ACUTE EXERCISE IN HUMAN SERUM METABOLOME
There is an increasing concern about the different response and effect that acute exercise induces on diabetic people and a novel insight into this effect can be performed using a metabolomic approach. Metabolomic is becoming widely spread used as a new and powerful tool for discerning significant changes at metabolic level. In this study we aimed to perform a non-targeted analysis and to identify metabolic differences arisen after 30 minutes of acute exercise in both young men suffering from Ty
Nucleic Acid Reagents and Experimental Results in the NCBI Probe Database
National Center for Biotechnology Information, NIH, Bethesda, MD
Five years ago, the NCBI Probe database (ProbeDB) was established to provide a centralized archive of molecular probes used in biomedical applications. Currently ProbeDB contains around 10 million probes of 65 types including gene silencing agents, in situ hybridization probes, and probes for variation analysis and genome mapping. Presently, ProbeDB is the largest and most extensive database of this type available in public domain.
Quantitative Determination of Total Bile Acids with a Thermo Scientific Varioskan Flash Multimode Reader Using a Kinetic Enzyme Cycling Assay
Thermo Fisher Scientific
Serum total bile acids (TBA) level is a long-established and accepted indicator of liver diseases. This application note presents a simple photometric measurement of serum TBA.
Optimization of Instrument Settings and Measurement Parameters for Kinetic Fluorometric and Luminometric Assays
Thermo Fisher Scientific
When fluorometric and luminometric assays are performed in microplate format, a high number of samples can be analyzed at a time. The speed of the reaction kinetics of the assay determines the requirements for the detection instrument and measurement parameters for achieving the best possible performance of the assay.
Pipetting performance of Thermo Scientific Finnpipette F2 in combination with Thermo Scientific Finntip Flex
Thermo Fisher Scientific
The Finnpipette® F2 product family has been designed by taking into account the demands of today´s laboratory work and the require¬ments of the end users. It offers superior comfort, performance, reliability and repeatability in one of the lightest pipettes available.
Using a Thermo Scientific Microplate Photometer to Choose an Optimum Reagent for Cytotoxicity Assays
Thermo Fisher Scientific
A number of different reagents can be used to perform photometric cell proliferation and viability assays. A microplate photometer can quickly determine which reagent is the best choice for an assay and then optimize the assay. Significant time savings and productivity gains can be achieved with this tool.
Ergonomics and Usability Study of Thermo Scientific Finnpipette F1 and F2 Pipettes
Thermo Fisher Scientific
The objective of the study was to evaluate the ergonomics and usability of six manual, singlechannel pipettes. This was done by measuring the load and strain symptoms exhibited by workers’ muscles and joints, and evaluating the usability features of pipettes in a simulated work situation.
Promega’s ADP-Glo™ Kinase Assay performed on BMG LABTECH’s PHERAstar FS and POLARstar Omega
BMG Labtech
The PHERAstar FS as well as the POLARstar Omega offer the ability to perform the ADP-Glo™ assay from Promega in a 384-well format. The ADP-Glo™ Kinase Assay is a homogenous luminescent assay to detect ADP in concentrations ranging from 1 mM to 0.01 µM. Instrument settings and standard ATP/ADP curves over a wide concentration range are presented for both the PHERAstar FS and the POLARstar Omega.
RADAR, a Xevo TQ-S function, combined with Low-High pH UPLC Screening for Fast, Simple Bioanalysis Methods Development
Waters Corporation
Here, we demonstrate the productivity gains possible with Xevo TQ-S for use in bioanalytical methods. Xevo TQ-S employs a unique RADAR functionality to collect data in the time scale of a narrow 1- to 2-second peak.
The Transcreener® ADP2 FI Assay performed on PHERAstar and Omega microplate readers
BMG LABTECH
alamarBlue® Assay for Assessment of Cell Proliferation using the FLUOstar OPTIMA
BMG LABTECH
A DELFIA® time-resolved fluorescence cell-mediated cytotoxicity assay performed on the PHERAstar
BMG LABTECH
Thermo Fisher Scientific
Serum total bile acids (TBA) level is a long-established and accepted indicator of liver diseases. This application note presents a simple photometric measurement of serum TBA.
Optimization of Instrument Settings and Measurement Parameters for Kinetic Fluorometric and Luminometric Assays
Thermo Fisher Scientific
When fluorometric and luminometric assays are performed in microplate format, a high number of samples can be analyzed at a time. The speed of the reaction kinetics of the assay determines the requirements for the detection instrument and measurement parameters for achieving the best possible performance of the assay.
Pipetting performance of Thermo Scientific Finnpipette F2 in combination with Thermo Scientific Finntip Flex
Thermo Fisher Scientific
The Finnpipette® F2 product family has been designed by taking into account the demands of today´s laboratory work and the require¬ments of the end users. It offers superior comfort, performance, reliability and repeatability in one of the lightest pipettes available.
Using a Thermo Scientific Microplate Photometer to Choose an Optimum Reagent for Cytotoxicity Assays
Thermo Fisher Scientific
A number of different reagents can be used to perform photometric cell proliferation and viability assays. A microplate photometer can quickly determine which reagent is the best choice for an assay and then optimize the assay. Significant time savings and productivity gains can be achieved with this tool.
Ergonomics and Usability Study of Thermo Scientific Finnpipette F1 and F2 Pipettes
Thermo Fisher Scientific
The objective of the study was to evaluate the ergonomics and usability of six manual, singlechannel pipettes. This was done by measuring the load and strain symptoms exhibited by workers’ muscles and joints, and evaluating the usability features of pipettes in a simulated work situation.
Promega’s ADP-Glo™ Kinase Assay performed on BMG LABTECH’s PHERAstar FS and POLARstar Omega
BMG Labtech
The PHERAstar FS as well as the POLARstar Omega offer the ability to perform the ADP-Glo™ assay from Promega in a 384-well format. The ADP-Glo™ Kinase Assay is a homogenous luminescent assay to detect ADP in concentrations ranging from 1 mM to 0.01 µM. Instrument settings and standard ATP/ADP curves over a wide concentration range are presented for both the PHERAstar FS and the POLARstar Omega.
RADAR, a Xevo TQ-S function, combined with Low-High pH UPLC Screening for Fast, Simple Bioanalysis Methods Development
Waters Corporation
Here, we demonstrate the productivity gains possible with Xevo TQ-S for use in bioanalytical methods. Xevo TQ-S employs a unique RADAR functionality to collect data in the time scale of a narrow 1- to 2-second peak.
The Transcreener® ADP2 FI Assay performed on PHERAstar and Omega microplate readers
BMG LABTECH
alamarBlue® Assay for Assessment of Cell Proliferation using the FLUOstar OPTIMA
BMG LABTECH
A DELFIA® time-resolved fluorescence cell-mediated cytotoxicity assay performed on the PHERAstar
BMG LABTECH
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