Corporate Banner
Satellite Banner
Metabolomics & Lipidomics
Scientific Community
Become a Member | Sign in
Home>News>This Article

Glutamic Acid Linked to Lower Blood Pressure

Published: Monday, July 06, 2009
Last Updated: Monday, July 06, 2009
Bookmark and Share
The new research suggests that glutamic acid may be one of the components of vegetable protein linked to lower blood pressure.

Glutamic acid may be one of the components responsible for the lower blood pressures of people with vegetable-rich diets, according to a study published today in Circulation: Journal of the American Heart Association. Glutamic acid is a major component of protein; vegetable protein contains higher levels of glutamic acid than animal protein.

Previous research by the authors, from Imperial College London and Northwestern University, Chicago, in collaboration with other institutions in the US, Japan and China, showed that people with more vegetable protein in their diet tend to have lower blood pressure. The new research suggests that glutamic acid may be one of the components of vegetable protein linked to lower blood pressure.

The researchers looked at diet and blood pressure data from over 4,000 people. They analyzed the amount of five amino acids in people's diets and found that, on average, people who consume more glutamic acid have lower blood pressure than those who consume less.

Dr Ian Brown, co-author of the study from the Department of Epidemiology and Public Health at Imperial College London, said: "After we observed that vegetable protein in the diet was linked to lower blood pressure, we wanted to know what elements of vegetable protein might be responsible. Our new research suggests that glutamic acid may partly explain the link between vegetable protein and lower blood pressure."

"The next steps will be to reproduce this finding in other studies, and investigate how glutamic acid might exert an effect on blood pressure. However, there is no 'magic bullet' for preventing high blood pressure, and vegetable protein and glutamic acid are individual elements of a broader healthy eating pattern," added Dr Brown.

The new study is in line with findings from the DASH diet, developed by the US National Institutes of Health and recommended by the American Heart Association. Proven to lower blood pressure, the diet is rich in fruit, vegetables and low-fat dairy products, as well as whole grains, lean poultry, nuts and beans - many of which are naturally high in glutamic acid.

The researchers analyzed data from 4,680 people aged 40-59, from the UK, USA, Japan and China. Participants were involved in the study for around three weeks, between 10 and 13 years ago. During their first visit to the clinic, participants completed a thorough questionnaire and interview about their daily food intake, gave a urine sample and had their blood pressure taken. The participants returned to the clinic the next day for a second questionnaire, interview and blood pressure reading. This process was repeated two to three weeks later.

The scientists calculated the amount of five different amino acids in the participants' diets and correlated amino acid levels with blood pressure. People with a higher proportion of glutamic acid in the protein they consumed (4.7%), had, on average, lower systolic blood pressure (by 1.5-3.0mmHg) and lower diastolic blood pressure (by 1.0-1.6mmHg).

Professor Paul Elliott, one of the authors of the study from the Department of Epidemiology and Public Health at Imperial College London, said: "A person with high blood pressure might have a reading of 140mmHg, so at first sight these differences don't look like much. However, from a population perspective this is important. High blood pressure is a risk factor for cardiovascular disease, so if we can reduce the population's blood pressure by just 1-2mmHg, we could reduce overall risk of heart disease."

"Many dietary factors can have small effects on blood pressure. In combination, these effects can become clinically relevant. We hope our research will help to develop optimal diets and advice to prevent and control high blood pressure, and reduce the burden of cardiovascular disease," added Professor Elliott.

Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,600+ scientific posters on ePosters
  • More than 3,800+ scientific videos on LabTube
  • 35 community eNewsletters

Sign In

Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Urine Profiles Provide Clues To How Obesity Causes Disease
Scientists have identified chemical markers in urine associated with body mass, providing insights into how obesity causes disease.
Thursday, April 30, 2015
Light-activated Drug Could Reduce Side Effects of Diabetes Medication
Scientists have created a drug for type 2 diabetes that is switched on by blue light, which they hope will improve treatment of the disease.
Thursday, October 16, 2014
Metabolic 'Fingerprinting' of Tumours Could Help Bowel Cancer Patients
New research makes it possible to see how advanced a bowel cancer is by looking at its metabolic 'fingerprint.'
Tuesday, August 13, 2013
New Laboratory Aims to Revolutionise Surgery with Real-Time Metabolic Profiling
Metabolic profiling of tissue samples could transform the way surgeons make decisions in the operating theatre, say researchers at a new laboratory being launched today.
Thursday, January 13, 2011
Some Morbidly Obese People are Missing Genes, Shows New Research
According to the new findings, around seven in every thousand morbidly obese people are missing a part of their DNA.
Friday, February 05, 2010
Heart Rhythm Gene Revealed in new Research
Discovery could help scientists design more targeted drugs to prevent and treat certain heart problems.
Monday, January 11, 2010
Research Reveals Exactly How Coughing is Triggered by Environmental Irritants
Scientists identify the reaction inside the lungs that can trigger coughing when a person is exposed to particular irritants in the air.
Monday, November 23, 2009
Ironing Out the Genetic Cause of Hemoglobin Problems
A gene with a significant effect on regulating hemoglobin in the body has been identified as part of a genome-wide association study.
Monday, October 12, 2009
Scientists Discover new Genetic Variation that Contributes to Diabetes
Study identifies a genetic variation in people with type 2 diabetes that affects how the body's muscle cells respond to the hormone insulin.
Tuesday, September 08, 2009
Think Zinc: Molecular Sensor Could Reveal Zinc's Role in Diseases
Scientists develop a new molecular sensor to analyze the amount of zinc in cells.
Tuesday, September 08, 2009
Urine Samples could be Used to Predict Responses to Drugs, Say Researchers
Researchers show possibility to predict how different individuals would deal with one drug by looking at metabolites in their urine.
Tuesday, August 11, 2009
On-the-spot DNA Analysis to Test Tolerance to Prescription Drugs Gets Closer
A handheld device to predict whether patients will respond adversely to medication is one step closer to the market.
Tuesday, February 17, 2009
Childhood Obesity Risk Increased 50 Percent by new Genetic Mutations, Says Study
Three new genetic mutations that together can increase a very young child's risk of becoming obese by 50 percent are revealed in a new study.
Wednesday, January 21, 2009
Common Mutations Linked to Common Obesity in Europeans
Scientists have discovered two common genetic mutations in people of European ancestry, which affect the production of several hormones controlling our appetite.
Monday, July 07, 2008
Causes of Disease Can Be Revealed By Metabolic Fingerprinting, According to 'Metabolome-Wide' Study
Your metabolic 'fingerprint' can reveal much about the possible causes of major diseases, according to the study published in the journal Nature.
Monday, April 21, 2008
Scientific News
Newly Identified Biochemical Pathway Could Be Target for Insulin Control
Researchers at Duke Medicine and the University of Alberta are reporting the identification of a new biochemical pathway to control insulin secretion from islet beta cells in the pancreas, establishing a potential target for insulin control.
Dirty,Crusty Meals Fit for (Long-Dormant) Microbes
Researchers apply the latest analytical techniques to further our understanding of desert biocrusts.
CSI -- On The Metabolite's Trail
Bioinformaticians at the University of Jena make the most efficient search engine for molecular structures available online.
Developing a Breathalyzer-Type Low Blood Sugar Warning Device For Diabetes
A multidisciplinary team of researchers at Indiana University-Purdue University Indianapolis has been awarded a $738,000 National Science Foundation grant to develop a breathalyzer-type device to detect the onset of hypoglycemia, or low blood sugar episodes, in people with diabetes.
Identifying The 'Dimmer Switch' Of Diabetes
University of Alberta research gives new insight into what causes Type 2 diabetes.
10 to 1: Bugs Win in NASA study
Bugs are winning out, and that's a good thing according to NASA's Human Research Program.
MYC Oncogene Disrupts Cancers Rhythm
Findings inform time-dependent treatment for reducing side effects and increasing effectiveness of cancer medications.
Keeping Gut Bacteria in Balance Could Help Delay Age-related Diseases
A new study suggests that analyzing intestinal bacteria could be a promising way to predict health outcomes as we age.
Genome Mining Effort Discovers 19 New Natural Products in Four Years
Each of these products is a potential new drug. One of them has already been identified as an antibiotic.
New CRISPR-Cas9 Strategy Edits Genes Two Ways
A team of Harvard and MIT researchers have developed a way to perform genome engineering and gene regulation at the same time.
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,600+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
3,800+ scientific videos