Thermo Fisher Scientific Inc. has announced collaboration with the integrative network biology initiative at The Institute of Cancer Research (ICR), UK. The ICR's new, proteomics laboratory is equipped with a complete Thermo Scientific proteomics workflow, including the Kingfisher Flex automated sample preparation system, the TSQ Vantage triple quadrupole and the UK's first two LTQ Orbitrap Velos mass spectrometers.
"Typically, cancer research focuses on the function and behavior of individual genes or proteins," explains Dr. Rune Linding, head of the cellular and molecular logic team at the ICR. "The ICR's effort aims to assess how networks of cancer cells interact with each other and surrounding tissues to metastasize, or spread, throughout the body. By modeling and simulating how cancer cells interact within the larger biological network, ICR researchers hope to achieve breakthroughs leading to new drugs or treatments that prevent metastasis - the process that claims the lives of about 90 percent of cancer patients."
Dr. Linding added: "Studying the dynamics of cellular networks requires state-of-the-art mass spectrometry. The LTQ Orbitrap Velos and TSQ Vantage systems enable us to push the boundaries and analyze completely new aspects of cellular signaling networks and perform massive scale studies of the dynamics in these networks. This is crucial as we believe the progression of cancer is due to changes in these molecular networks."
The collaboration involves a number of Thermo Fisher Scientific solutions, including laboratory equipment, silencing RNA, protein reagents, mass spectrometry and related services. Anthony Sullivan, proteomics team leader for Thermo Fisher Scientific, said, "We are immensely proud of our unique ability to serve this essential research and pleased with the opportunity to work so closely with such a talented and motivated team of scientists."