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ChromaDex® and Scripps Research Institute Collaborate on METLIN Metabolite Database

Published: Friday, June 01, 2012
Last Updated: Friday, June 01, 2012
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The collaboration with The Scripps Center for Metabolomics will generate tandem mass spectrometry data for compounds from the ChromaDex natural products and phytochemical catalog.

The Scripps METLIN Metabolite Database is a repository of metabolite information that includes tandem mass spectrometry data for over 55,000 unique and potentially therapeutic compounds. It is a public, web-based database designed for the archiving, visualization, and analysis of metabolite data. The information is provided to facilitate metabolomics experiments by providing scientists with a comprehensive source of structures for potential metabolites of their compounds of interest. An annotated list of known metabolites and their mass, chemical formula, and structure are available on the METLIN website. The METLIN database was developed and is maintained by the Siuzdak laboratory at the Scripps Research Institute, La Jolla, California.

Currently, there is limited information for natural products in the database. By expanding the population of data, it will increase the knowledge base and visibility for researchers to screen potential compounds for use in areas of clinical interest, such as cancer, heart disease, diabetes, or Alzheimer's.

"We are very excited about expanding the METLIN metabolite database with the ChromaDex phytochemicals.  METLIN is currently the largest repository of metabolite tandem mass spectrometry data.  This important class of ChromaDex compounds will expand METLIN's compound library and mass spectrometry data to nutraceuticals and many novel plant-related natural products.   The importance in the ChromaDex/METLIN partnership is that it will facilitate metabolomics experiments around the world." states Gary Siuzdak Ph.D, Senior Director, Center for Metabolomics and Mass Spectrometry Scripps Research Institute.

Frank Jaksch, Founder and CSO for ChromaDex, stated "Collaborating with Scripps Research Institute with our natural product libraries will further advance small molecule profiling to increase demand for natural product libraries through the ease of the Internet to assist in finding candidate compounds for research and development."

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