Corporate Banner
Satellite Banner
Metabolomics & Lipidomics
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Thermo Scientific Introduces New-generation Triple Quadrupole LC-MS Platform

Published: Tuesday, June 11, 2013
Last Updated: Tuesday, June 11, 2013
Bookmark and Share
New Thermo Scientific TSQ Quantiva LC-MS breaks attogram sensitivity barrier.

Thermo Fisher Scientific Inc. has introduced a new-generation triple quadrupole liquid chromatography-mass spectrometry (LC-MS) platform designed to transform quantitation experiments with extreme sensitivity, productivity, precision and usability.

The platform, which includes the new Thermo Scientific Quantiva triple-stage quadrupole mass spectrometer and the new Thermo Scientific Endura triple-stage quadrupole mass spectrometer, made its debut at the ASMS Conference on Mass Spectrometry and Allied Topics, being held in Minneapolis from June 9-13 at the Minneapolis Convention Center in booth 154.

“Evolving applications continue to push the limits of instrument performance,” said Iain Mylchreest, vice president of research and development, chromatography and mass spectrometry, Thermo Fisher Scientific.

Mylchreest continued, “We have created a completely new instrument platform, built from the ground up, to deliver extreme sensitivity and uptime. Equally important is a great user experience, easy method creation and accessible data analysis and review. We believe this is the highest-performing, most-usable triple quad on the market today.”

The TSQ Quantiva triple quadrupole mass spectrometer employs Active Ion Management (AIM) to optimize ion creation and transmission from the source to the detector, resulting in extreme sensitivity.

This enhanced level of sensitivity greatly improves results in applications such as peptide quantitation, metabolomics and biopharmaceutical QA/QC compared to previous Thermo Fisher triple quads.

In company laboratories, AIM-enhanced systems have measured 70 attograms of verapamil in plasma on column with excellent precision, an unprecedented level of performance.

The TSQ Quantiva MS system is also extremely productive, with the ability to perform 500 SRM experiments per second, and positive/negative polarity switching in 20ms with no signal loss.

Productivity is enhanced by a new Ion Beam Guide and Neutral Blocker that helps keep components free of contamination and eases maintenance when it is required.

The TSQ Quantiva MS has been shown using synthetic serum stress tests to operate approximately three times longer between maintenance intervals than the company’s previous best systems, without loss of signal.

The TSQ Endura triple quadrupole mass spectrometer shares much of the advanced technology of the TSQ Quantiva MS, but was designed to deliver higher uptime than any competitive triple quadrupole instrument.

It was built for workhorse applications requiring trace level quantitation, such as food testing, environmental analysis and pharmaceutical QA/QC.

Common Sources and Software
The TSQ Quantiva MS system uses the same source housings as the company’s new Orbitrap Fusion Tribrid LC-MS system, which was also introduced at ASMS. Both are designed for plug-and-play exchange between each other.

Gas and electrical connections are made automatically when sources are installed, and ESI, APCI, and nanospray housings and probes are automatically recognized by the system.

The new triple quads share common software with the new Orbitrap Fusion Tribrid system, making it easier to learn and use both systems. Method parameters can automatically pass between systems to support discovery and verification studies employing both instruments.

“Improved usability was a core goal of this project,” added Mylchreest. “We know many customers use both our hybrid and our triple quad technologies, and we have created an environment that makes it as easy as possible to leverage both systems in the same laboratory.”


Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,500+ scientific posters on ePosters
  • More than 3,700+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Thermo Fisher Scientific Signs Distribution Agreement with MKI
The agreement sees Thermo become the exclusive worldwide marketer and distributor of MKI’s Lipid Search software for interpretation of lipidomic research data.
Tuesday, July 09, 2013
Scientific News
New ACE-inhibiting Molecule Found in the Asparagus
Scientists have determined that sulfur-containing compounds in plants can inhibit ACE.
A Metabolic Master Switch Underlying Human Obesity
Researchers find pathway that controls metabolism by prompting fat cells to store or burn fat.
Shedding Light On Century-Old Biochemical Mystery
Yale scientists have used magnetic resonance measurements to show how glucose is metabolized in yeast to answer the puzzle of the “Warburg Effect.”
PTR-MS Breath Test Shows Potential for Detecting Liver Disease
Researchers at the University of Birmingham have published results that suggest a non-invasive breath test for liver disease using an IONICON PTR-MS.
Metabolon and BCM Show Metabolomics May Play Key Role in Precision Medicine
Metabolon’s technology enhances understanding of genetic data and improves health assessment in newly published study.
Newly Discovered Cells Restore Liver Damage in Mice Without Cancer Risk
The liver is unique among organs in its ability to regenerate after being damaged. Exactly how it repairs itself remained a mystery until recently, when researchers supported by the NIH discovered a type of cell in mice essential to the process
Study Finds Cutting Dietary Fat Reduces Body Fat More than Cutting Carbs
In a recent study, restricting dietary fat led to body fat loss at a rate 68 percent higher than cutting the same number of carbohydrate calories when adults with obesity ate strictly controlled diets.
Inappropriate Medical Food Use in Managing Patients with a Type of Metabolic Disorder
Researchers have proposed that there is a need for more rigorous clinical study of dietary management practices for patients with IEMs, including any associated long-term side effects, which may in turn result in the need to reformulate some medical foods.
Medical Researchers a Step Closer to Developing Anti-Obesity Pill
A weight loss pill could soon be possible thanks to the work of Deakin University medical researchers.
Engineered Bacterium Produces Important Industrial Chemical
A Korean research team has reported the production of 1,3-diaminopropane via fermentation of an engineered bacterium.
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,500+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
3,700+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FREE!