Corporate Banner
Satellite Banner
Metabolomics & Lipidomics
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Eating Broccoli Retunes Metabolism

Published: Thursday, August 01, 2013
Last Updated: Thursday, August 01, 2013
Bookmark and Share
Researchers have obtained the first evidence from human studies of how diets rich in glucosinolates can 're-tune' cellular processes that get disrupted as we age.

Retuning these processes to normal may contribute to the reduced risk of cancer seen in people who eat diets rich in broccoli and similar vegetables. A high glucoraphanin broccoli variety, called Beneforté, is now available in UK supermarkets.

Inside each of our cells are specialised structures called mitochondria, which act as the engines of the cell. Mitochondria either burn up dietary fats and sugars to make energy or export them to be used by the cell as the building blocks to make other compounds needed for health. Mitochondria can also convert fats and sugars into forms for storage, which is how we can put on weight if we eat too much. For good health, we need to balance all these different metabolic activities.

Excessive fat or sugar in the diet can overload the mitochondrial machinery. Also, as we age, this machinery works less efficiently, especially if we do not have sufficient exercise. This is because of the build-up of Reactive Oxygen Species (ROS) in the mitochondria that inhibit some of the metabolic processes. The mitochondria may also begin to produce other compounds that can cause chronic inflammation. Disturbed metabolism and badly functioning mitochondria are associated with the development of chronic diseases such as obesity, Type II diabetes, cardiovascular disease and some forms of cancer.

To study what effects glucosinolate consumption has on metabolism, the researchers at the IFR carried out human dietary intervention trials. These involve making controlled and very specific changes to people's diets over a period of time, and provide the best possible evidence for the effects specific foods have on our bodies and metabolism.

48 volunteers were randomly split into three groups. Over a period of 12 weeks, one group ate high glucoraphanin broccoli, one group ate standard broccoli, and the third ate no broccoli. The researchers measured 346 metabolites in the blood before and after the 12 week period. They found that people who ate the high glucoraphanin broccoli had improved metabolism, and most of them had reduced levels of fatty acids in the blood and other lipid compounds that are associated with inflammation. They concluded that this was because of a bioactive compound called sulforaphane that is derived from glucoraphanin. This switched on 'antioxidant' genes which reduced the excessive ROS in the cells enabling their metabolic machinery to work better.

A number of studies have shown that diets rich in cruciferous vegetables may reduce the risk of cancer, type II diabetes and other chronic diseases of ageing through the actions of glucosinolates. This new study, published in the American Journal of Clinical Nutrition, provides the first evidence from human intervention trials of the mechanism behind this protective effect. This is being followed up by another study with a larger number of volunteers that is also looking at metabolism and biomarkers of cardiovascular health.

In 2011, a high glucoraphanin variety of broccoli was launched in UK supermarkets following significant investment in research from the Biotechnology and Biological Sciences Research Council (BBSRC). Beneforté 'super broccoli' represents a special achievement for UK bioscience: a consumer-focused, nutritionally-enhanced product. Beneforté broccoli was developed through traditional breeding techniques by the Institute of Food Research and the John Innes Centre on the Norwich Research Park, both of which receive strategic funding from BBSRC.


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,100+ scientific posters on ePosters
  • More than 4,500+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Study Maps Human Metabolism in Health and Disease
Scientists have produced an instruction manual for the human genome that provides a framework to better understand the relationship between an individual's genetic make-up and their lifestyle.
Tuesday, March 05, 2013
Scientific News
New Treatment for Pancreatic Cancer
Researchers at Purdue University have shown how controlling cholesterol metabolism in pancreatic cancer cells reduces metastasis.
Plasma Biomarkers for Breast Cancer Diagnosis
Plasma lipidomics profiling identified lipid biomarkers in distinguishing early-stage breast cancer from benign lesions.
How Different People Respond To Aspirin
Study findings could be used to help identify those who would benefit most from aspirin use.
Altered Metabolism of Four Compounds Drives Glioblastoma Growth
Findings suggest new ways to treat the malignancy, slow its progression and reveal its extent more precisely.
A Metabolic Twist that Drives Cancer Survival
A novel metabolic pathway that helps cancer cells thrive in conditions that are lethal to normal cells has been identified.
Liver-On-Chip Tracks Dynamics of Cellular Function
Hebrew University’s liver-on-chip platform is uniquely able to monitor metabolic changes indicating mitochondrial damage occurring at drug concentrations previously regarded as safe.
Living Off the Fat of the Land
Do cancer cells synthesize the parts for new cells or scavenge them from the environment?
Liver Disease, Obesity Linked
Kanazawa University researchers find similarities in the impeded signalling between central insulin activity and glucose production in the liver for both obese mice and mice that have had the vagus nerve removed.
Decoding Ties Between Vascular Disease, Alzheimer’s
NIH consortium uses big data, team science to uncover complex interplay of factors.
Gene Identified that May Worsen Cancer Outcome
Some patients with breast cancer, lung cancer and leukaemia seem to fare poorly after treatment because of the effects of a particular gene, a new study finds.
SELECTBIO

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,100+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,500+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!