Corporate Banner
Satellite Banner
Metabolomics & Lipidomics
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

GW Receives up to $14.6M to Develop Method for Characterizing Security Threats

Published: Wednesday, January 29, 2014
Last Updated: Monday, February 03, 2014
Bookmark and Share
The researchers are tasked with reducing to 30 days a process that can sometimes take years or even decades.

A team led by a George Washington University (GW) researcher will receive up to $14.6 million over five years from the Defense Advanced Research Projects Agency (DARPA) to develop an approach to rapidly identify the root of biological and chemical threats. If successful, the approach could bolster national security efforts to combat these threats.

“Clearly, this is a very large challenge, and it’s easy to understand why it’s important to overcome,” said Akos Vertes, George Washington University professor of chemistry in the Columbian College of Arts and Sciences. “Discovering the cause behind a biological or chemical threat can provide information that not only counteracts the threat but also provides important information for pharmaceutical companies developing drugs that may be unrelated to the threat.”

Biological threats, such as anthrax, derive from bacteria, while others derive from viruses, toxins or fungi.  Chemical threats include substances that work to interfere with the nervous system or even cause asphyxiation. These threats have the potential to cause widespread, rapid injury or death.

To determine how a biological or chemical threat disrupts life functions, researchers must take a holistic view of the threat and the system in which it is working. The team will examine the effects of toxic agents on genes, proteins and cellular functions using the scientific disciplines of transcriptomics, proteomics, metabolomics and bioinformatics to meet the 30-day challenge. By combining an immense amount of data gleaned from these disciplines, researchers believe it will be easier to determine the workings of a given biological or chemical threat in a given environment.

One problem in achieving this, though, is the fact that the field of metabolomics isn’t as well-developed as other scientific disciplines. However, Dr. Vertes and his team at GW recently developed the Laser Ablation Electrospray Ionization (LAESI) technique, which allows researchers to more quickly and effectively learn the chemical composition of a biological sample. The technique was licensed to Protea Biosciences Inc., which developed the commercial product— the LAESI-DP 1000 Direct Ionization System—last year.

GE Global Research, Protea Biosciences Inc., and SRI International will collaborate with GW on this project, titled, “New Tools for Comparative Systems Biology of Threat Agent Action Mechanisms.”


Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,500+ scientific posters on ePosters
  • More than 3,800+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.


Scientific News
New ACE-inhibiting Molecule Found in the Asparagus
Scientists have determined that sulfur-containing compounds in plants can inhibit ACE.
A Metabolic Master Switch Underlying Human Obesity
Researchers find pathway that controls metabolism by prompting fat cells to store or burn fat.
Shedding Light On Century-Old Biochemical Mystery
Yale scientists have used magnetic resonance measurements to show how glucose is metabolized in yeast to answer the puzzle of the “Warburg Effect.”
PTR-MS Breath Test Shows Potential for Detecting Liver Disease
Researchers at the University of Birmingham have published results that suggest a non-invasive breath test for liver disease using an IONICON PTR-MS.
Metabolon and BCM Show Metabolomics May Play Key Role in Precision Medicine
Metabolon’s technology enhances understanding of genetic data and improves health assessment in newly published study.
Newly Discovered Cells Restore Liver Damage in Mice Without Cancer Risk
The liver is unique among organs in its ability to regenerate after being damaged. Exactly how it repairs itself remained a mystery until recently, when researchers supported by the NIH discovered a type of cell in mice essential to the process
Study Finds Cutting Dietary Fat Reduces Body Fat More than Cutting Carbs
In a recent study, restricting dietary fat led to body fat loss at a rate 68 percent higher than cutting the same number of carbohydrate calories when adults with obesity ate strictly controlled diets.
Inappropriate Medical Food Use in Managing Patients with a Type of Metabolic Disorder
Researchers have proposed that there is a need for more rigorous clinical study of dietary management practices for patients with IEMs, including any associated long-term side effects, which may in turn result in the need to reformulate some medical foods.
Medical Researchers a Step Closer to Developing Anti-Obesity Pill
A weight loss pill could soon be possible thanks to the work of Deakin University medical researchers.
Engineered Bacterium Produces Important Industrial Chemical
A Korean research team has reported the production of 1,3-diaminopropane via fermentation of an engineered bacterium.
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,500+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
3,800+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FREE!