Corporate Banner
Satellite Banner
Metabolomics & Lipidomics
Scientific Community
Become a Member | Sign in
Home>News>This Article

Agilent Supports NUS-Led Research Consortium to Identify, Map Lipid Levels in Healthy People

Published: Monday, March 17, 2014
Last Updated: Monday, March 17, 2014
Bookmark and Share
New international effort to develop world's first integrated systems biology database for different races and ethnicities.

Agilent Technologies announced its support for a new international research consortium, led by the National University of Singapore (NUS), that aims to develop the world's first lipid1 database for healthy persons of different racial and ethnic groups.

Using the lipid database, scientists and researchers hope to better understand the healthy and unhealthy "fat" levels in people of different racial and ethnic backgrounds. This knowledge will pave the way for medical professionals to leverage such key information as diagnostic markers for their patients in future.

The Lipidomic Natural Variation (L-NAVA) consortium is founded by the Singapore Lipidomics Incubator (SLING) at NUS. Other founding members include South Korea's Graduate School of Analytical Science and Technology (GRAST) at Chungnam National University; Baker IDI Heart and Diabetes Institute, a medical research institute located in Melbourne, Australia; and Agilent, which is L-NAVA's preferred technology partner.

Using methodology created by SLING, the teams at GRAST and Baker IDI will undertake similar studies in their domestic markets; the results will be compiled into a database. (SLING recently concluded a study of 360 healthy subjects from three major ethnic groups-Chinese, Indian and Malay-in Singapore. Through that study, SLING was able to identify the upper and lower limits of the normal fat levels for healthy people in the three groups.)

The lipid information (L-NAVA) will be integrated with glycomic (G-NAVA) and proteomic (P-NAVA) studies, to provide insight into natural variation within glycans and proteins as well.

"Understanding natural variations is a major aim of SLING," said associate professor Markus Wenk, director of SLING. "This network allows us to extend, and hopefully connect, our studies on lipids with others that address variability at the level of genes, proteins and sugars. Doing this in healthy individuals will provide a broad, foundational basis relevant for a better understanding of onset of diseases." Dr. Wenk is also a faculty member at the Department of Biochemistry at the Yong Loo Lin School of Medicine at NUS and the Department of Biological Sciences at the NUS Faculty of Science.

"We are honored to be part of this new consortium, supporting its goal to systematically determine lipid profiles across different groups of humans," said Agilent's Rod Minett, general manager, Life Sciences, South Korea and the South Asia-Pacific region. "Agilent's innovations in bio-analytical instruments will help consortium members in their research on the natural variations using different methods. We hope this resource will help medical professionals provide better-quality care to their patients."

Principal investigators in the L-NAVA consortium are professor Wenk; professor Hyun Joo An, head of department at GRAST; associate professor Peter Meikle, head of Metabolomics at Baker IDI; and Dr. Rudolf Grimm, Agilent's director of Science and Technology and manager of collaborations in the Asia-Pacific region.

"Lipidomics has the potential to deliver significant new advances in medicine," said Professor Meikle. "These include being able to predict a person's risk of disease, understanding what causes that disease and being able to monitor and adjust treatments more effectively. However, to achieve these advances we must first understand the natural variation within different ethnic groups. We can then identify more accurately where abnormal lipid metabolism may be contributing to diseases including heart disease and diabetes."

"We are happy to be a founding member of this international consortium for lipidomics research," said professor An. "Although we have been focusing on the natural variation on serum glycoproteins to predict disease, we believe that the variation of glycans on lipid molecules can play a critical role in helping the scientific community gain deeper insights into the biological aspects of life. Our team at Asia Glycomics Reference Site is keen and ready to expand our research to lipidoglycomics, as glycolipids are closely involved in the development of neurons and their aging. This is a diversified yet interesting field that will benefit the global scientific and even medical communities."

All members of the consortium use Agilent's industry-leading triple quadrupole LC/MS system with ion funnel (iFunnel) technology in their lipidomics research. The Agilent iFunnel technology offers scientists and researchers the highest sensitivity and detection levels in their quest for scientific breakthroughs.

Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,800+ scientific posters on ePosters
  • More than 4,000+ scientific videos on LabTube
  • 35 community eNewsletters

Sign In

Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Agilent Collaborate with National University of Singapore
Company to support NUS Medicine's research for safer, more effective medicine for heart disease.
Friday, April 24, 2015
Scientific News
Gut Microbes Signal to the Brain When They're Full
Don't have room for dessert? The bacteria in your gut may be telling you something.
Turning up the Tap on Microbes Leads to Better Protein Patenting
Mining millions of proteins could become faster and easier with a new technique that may also transform the enzyme-catalyst industry, according to University of California, Davis, researchers.
Drug May Prevent Life-Threatening Muscle Loss in Advanced Cancers
New data describes how an experimental drug can stop life-threatening muscle wasting (cachexia) associated with advanced cancers and restore muscle health.
Cancer-Fighting Tomato Component Traced
The metabolic pathway associated with lycopene, the bioactive red pigment found in tomatoes, has been traced by researchers at the University of Illinois.
Circadian Clock Controls Insulin and Blood Sugar in Pancreas
Map of thousands of genes suggests new therapeutic targets for diabetes.
Cellular Stress Process Identified in Cardiovascular Disease
Combining the investigative tools of genetics, transcriptomics, epigenetics and metabolomics, a Duke Medicine research team has identified a new molecular pathway involved in heart attacks and death from heart disease.
Predicting Adverse Drug Reactions with Higher Confidence
A new integrated computational method helps predicting adverse drug reaction—which are often lethal—more reliably than with traditional computing methods.
A New Way to Starve Lung Cancer?
Metabolic alterations in lung cancer may open new avenues for treating the disease.
Evidence of How Incurable Cancer Develops
Researchers in the West Midlands have made a breakthrough in explaining how an incurable type of blood cancer develops from an often symptomless prior blood disorder.
Building a Better Liposome
Computational models suggest new design for nanoparticles used in targeted drug delivery.
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,800+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,000+ scientific videos