Corporate Banner
Satellite Banner
Metabolomics & Lipidomics
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Diabetes Duration and Severity Associated with Brain Atrophy

Published: Wednesday, April 30, 2014
Last Updated: Wednesday, April 30, 2014
Bookmark and Share
Type 2 diabetes may be associated with brain degeneration, according to a new multicenter study published online in the journal Radiology.

The study also found that, contrary to common clinical belief, diabetes may not be directly associated with small vessel ischemic disease, where the brain does not receive enough oxygenated blood.

"We found that patients having more severe diabetes had less brain tissue, suggesting brain atrophy," said lead author R. Nick Bryan, M.D., Ph.D., professor of radiology at the Perleman School of Medicine at the University of Pennsylvania. "They did not seem to have more vascular disease due to the direct effect of diabetes."

According the American Diabetes Association (ADA), nearly 26 million people in the United States have diabetes, and 1.9 million more are diagnosed with the disease each year. Type 2 is the most common form of diabetes. In type 2 diabetes, either the pancreas does not produce enough insulin or the cells ignore the insulin that is produced. The ADA estimates that, based on current trends, as many as one in three American adults will have diabetes in the year 2050.

"As diabetes becomes more common, better understanding of the disease and its management becomes even more important in order to minimize its effect on patient health," Dr. Bryan said.

For the study, Dr. Bryan and colleagues used magnetic resonance imaging (MRI) to investigate the association between severity and duration of type 2 diabetes mellitus and brain structure in 614 patients (mean age 62 years) at four participating centers (University of Minnesota, Minneapolis, Minn.; Wake Forest Medical School, Winston-Salem, N.C.; Columbia University, New York, N.Y.; and Case Western Reserve University, Cleveland, Ohio). The mean duration of disease in the study group was 9.9 years. The researchers specifically tested whether more severe diabetes was inversely correlated with brain volumes and positively correlated with ischemic lesion volumes.

The results showed that longer duration of diabetes was associated with brain volume loss, particularly in the gray matter. However, the study found no association of diabetes characteristics with small vessel ischemic disease in the brain.

"Diabetes duration correlated primarily with brain atrophy," Dr. Bryan said. "Stated another way, our results suggested that, for every 10 years of diabetes duration, the brain of a patient with diabetes looks approximately two years older than that of a non-diabetic person, in terms of gray matter volume."

The researchers noted that their findings may have implications for future decline of cognitive function in patients with diabetes and raise the possibility that such cognitive changes might not be strongly related to vascular dementia but to neurodegenerative disorders, such as Alzheimer's disease.


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 4,000+ scientific posters on ePosters
  • More than 5,300+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.


Scientific News
Metabolite Promotes Cancer Cell Transformation
Researchers have identified a metabolite that promotes cancer cell transformation and colorectal cancer spread.
Gut Bacteria Affect Our Metabolism
Study confirms, mice that receive gut bacteria transplants from overweight humans gain more weight than mice transplanted with gut bacteria from normal weight subjects.
The Benefits of a Mediterranean-style Diet
A Western-style diet, with more omega-6 fatty acids than the Mediterranean, dysregulates lipid signaling in aged mice and promotes inflammation.
Gut Bacteria Control Glucose Metabolism
Researchers have uncovered a link between the immune system, gut bacteria and glucose metabolism.
Peer Review is in Crisis, But Should be Fixed, Not Abolished
After the time to get the science done, peer review has become the slowest step in the process of sharing studies, and some scientists have had enough.
Plants Modulate Metabolite Accumulation at Organ Level
Scientists develop computational metabolomic approach to measure metabolic diversity in different plant tissues.
Gut Microbiome Linked to Inflammatory Proteins
Study looking at influence of genetics, microbiome and environment on immune response links intestinal microbial population to production of inflammatory proteins.
How it Works: Advanced Data Analysis Using Visualization
Visualisation of data can be used to help molecular biologists tackle the vast datasets their experiments create.
Cell Metabolism Linked to Spread of Cancer
Scientists discover macrophage metabolism can be attuned to prevent the spread of cancer.
Integrated Omics Analysis
Studying multi-omics promises to give a more holistic picture of the organism and its place in its ecosystem, however despite the complexities involved those within the field are optimistic.
SELECTBIO

SELECTBIO Market Reports
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
4,000+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
5,300+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!