Corporate Banner
Satellite Banner
Metabolomics & Lipidomics
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

New Study Reveals Interplay between Genetics and Metabolism in Complex Disease

Published: Saturday, May 17, 2014
Last Updated: Saturday, May 17, 2014
Bookmark and Share
Metabolomic profiling coupled with genomics data yields new insight into diseases, potential biomarkers and drug treatments.

Metabolon, Inc. has announced the publication of a paper entitled “An Atlas of Genetic Influences on Human Blood Metabolites” in Nature Genetics. Co-authored by Metabolon scientists, this paper is the result of a third genome-wide association study (GWAS) that combines genomic data and metabolic profiling to gain comprehensive understanding of the human biological system and presents the most comprehensive metabolomics survey of human metabolism conducted to date.

Building on earlier work published in Nature in 2011, Metabolon, in collaboration with a team of researchers led by Pfizer, King’s College London, Helmholtz Zentrum München, Weill Cornell Medical College in Qatar and Wellcome Trust Sanger Institute, among others, measured over 500 blood metabolites of nearly 8,000 study participants.

This effort revealed hundreds of exceptionally strong associations between metabolites and genetic variants. These associations provide a system-wide atlas of the effective activity of human genes and allelic differences, potentially improving disease understanding and providing new opportunities for drug development.

“One of the great conundrums in genomic research, aside from determining gene function, is to determine the biological meaning, if any, of allelic differences,” commented Michael Milburn, Ph.D., Chief Scientific Officer at Metabolon and one of two Metabolon authors to the publication. “Metabolic-allelic associations have the potential to provide a better understanding of gene function and can be enormously helpful in teasing apart genetic differences to improve biological understanding.”

“This study illustrates the power of discovery metabolomics to ‘complete the picture’ in human genomic studies aimed at understanding the complexity of human health,” said John Ryals, Ph.D, President and CEO of Metabolon. “The last decade of genomics research has revealed an even deeper level of complexity than once thought. Advanced metabolomics technology has the potential to bridge complex genetic and proteomic data to provide enhanced insight into the individual phenotype. We are grateful for the efforts of our long-term collaborators, Prof. Tim Spector, Prof. Karsten Suhre and Prof. Gabi Kastenmueller, for their leadership and dedication to this project. It is a tour de force of modern genomic and metabolomic research.”

Metabolon has several ongoing initiatives that utilize its proprietary metabolomics technology to advance genomics-based health research. These include strategic partnerships with Craig Venter’s new genomics initiative, Human Longevity, Inc., and the Global Genomics Group (G3).

These collaborations demonstrate increasing awareness among scientific experts about the important role metabolomics can play in other forms of ‘omic’ research.


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,200+ scientific posters on ePosters
  • More than 4,800+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Study Shows Quantose IR™ Measures Insulin Sensitivity Better
Results were recently published online by the Journal of Clinical Endocrinology & Metabolism.
Wednesday, April 01, 2015
Metabolon, Baylor Partner to Screen for Inborn Errors of Metabolism
The two-year, exclusive agreement will provide global Metabolomic-Assisted Pathway Screening (MAPS) services for individuals with suspected inborn errors of metabolism (IEMs).
Thursday, September 04, 2014
Metabolon, Geisinger Partner on Prediabetes Study
Metabolon will sponsor a pilot study to evaluate its Quantose IRTM test as a monitor of glycemic control in people with prediabetes.
Friday, June 27, 2014
Interplay between Genetics and Metabolism in Complex Disease Revealed
Metabolomic profiling coupled with genomics data yields new insight into diseases, potential biomarkers and drug treatments
Friday, May 16, 2014
Metabolon Enters into Collaboration with GSK
Agreement will see Metabolon provide metabolomic profiling services to GlaxoSmithKline.
Wednesday, May 14, 2014
Metabolon Debuts New Client Portal at Bio-IT World Expo
MetaboLync™ is a cloud-based solution for sharing, visualizing, and analyzing metabolomics data.
Wednesday, April 30, 2014
Microbes and Metabolites Fuel an Ambitious Aging Project
Craig Venter’s new company wants to improve human longevity by creating the world’s largest, most comprehensive database of genetic and physiological information.
Wednesday, March 12, 2014
Collaboration Agreement to provide Metabolomic Profiling Services
Metabolon Inc will assist Human Longevity Inc to build the world’s largest and most complete human genotype, microbiome and phenotype database.
Wednesday, March 05, 2014
Metabolon Closes $15 Million Series E Financing
Company raises $15 million through the issuance of preferred stock.
Monday, January 06, 2014
Global Genomics Group and Metabolon to Collaborate
Metabolon will conduct biochemical profiling in single largest prospective pan-omic study.
Thursday, November 14, 2013
Metabolon and Bostwick Laboratories Announce Marketing Agreement
Under the Agreement Bostwick will market Prostarix™, a non-invasive urine test for stratifying prostate cancer risk.
Monday, November 04, 2013
Metabolon Announces Findings from Two Major Diabetes Outcomes Studies
This provides further evidence that the Quantose test identifies individuals at risk for type 2 diabetes earlier and more accurately than traditional risk factors alone.
Tuesday, June 25, 2013
Impaired Metabolism in Cystic Fibrosis Lung Epithelial Cells Revealed by Metabolic Analysis
Metabolon announces publication of “Metabolomic Profiling Reveals Biochemical Pathways and Biomarkers Associated with Pathogenesis in Cystic Fibrosis Cells”.
Monday, October 25, 2010
Metabolon Awarded US Patent for Metabolic Biomarkers of Efficacy of PPAR Affecting Drugs
The USPTO awarded the patent to Metabolon on October 5, 2010.
Thursday, October 21, 2010
Metabolon Extends Biochemical Understanding of Alzheimers Disease
Publishes “Ablation of the Locus Coeruleus Increases Oxidative Stress in Tg-2576 Transgenic But Not Wild-type Mice” in the International Journal of Alzheimer Disease.
Thursday, October 14, 2010
Scientific News
Accessing Metabolic Information with Mass Spec
Scientists at the Helmholtz Zentrum München have developed a new mass spectrometry imaging method which, for the first time, makes it possible to analyze hundreds of metabolites in fixed tissue samples.
Improving Tumour Therapy with Nanoparticles
UHN nanoparticle called PEARLs is a promising utilisation of photo-thermal therapy for cancer treatment.
Exosome Research and Quality Control Using ZetaView
Particle Matrix's ZetaView particle characterisation system used by Cell Guidance Systems for exosome research.
Natural Metabolite Can Suppress Inflammation
An international group of scientists from US, Canada, Germany and Russia has revealed a substance produced in humans that can suppress the pro-inflammatory activity of macrophages – specific cells of immune system.
Some Women With PCOS May Have Adrenal Disorder
Researchers at NIH have found that a subgroup of women with PCOS, a leading cause of infertility, may produce excess adrenal hormones.
Making Metabolite Identification More Efficient
Metasense combines the industry's most-comprehensive metabolic transformation prediction with efficient analysis of LC/MS analytical measurements to identify, visualize, and report chemical biotransformations.
Mothers Obesity Could be Passed on in mtDNA
Obesity can predispose offspring in multiple generations to metabolic problems.
ASMS 2016: Targeting Mass Spectrometry Tools for the Masses
The expanding application range of MS in life sciences, food, energy, and health sciences research was highlighted at this year's ASMS meeting in San Antonio, Texas.
What Makes a Good Scientist?
It’s the journey, not just the destination that counts as a scientist when conducting research.
Copper is Key in Burning Fat
Berkeley Lab scientist says results could provide new target for obesity research.
SELECTBIO

SELECTBIO Market Reports
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,200+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,800+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!