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Interactive Metabolomics by Diffusion NMR: Improving the Odds of Finding Needles in Haystacks
Jonathan Byrne, Rasmus Bro, Florian Wulfert and Clare A. Daykin

Metabolomics investigates changes in quantities of metabolites. However, blood plasma is a complex, heterogeneous mixture of components which undergo a variety of possible molecular interactions. In particular, many low molecular weight compounds (including drugs) can exist both ‘free’ in solution, bound to proteins or within organised aggregates of macromolecules. To study the effects of e.g. disease on these interactions we have developed a technique termed ‘interactive metabolomics’.

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A compartmented in silico model of Rapeseed central metabolism
Eleftherios Pilalis, Aristotelis Chatziioannou, Fragiskos Kolisis

A large-scale in silico model was constructed for the simulation of the central metabolism of Rapeseed embryos. In order to validate this model, we performed constraint-based Flux Balance Analysis, through application of linear optimization methods. Further exploiting the derived model, an in silico gene deletion analysis and a systemic regulatory analysis by Singular Value Decomposition of the steady-state flux space were performed.

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SYBR® Green I as a biomarker for schizophrenia
Davood Zaeifi, Mehdi Rahmati, Vahab Piranfar

The purpose of this study were to examine if the mRNA of the peripheral dopamine receptor is changed in schizophrenia patients. 50 Naive patients were enrolled. After extracting RNA from white blood cells, cDNA is synthesized. After doing the quantitative Real-time PCR, expression of D3 receptors in healthy persons and patients were compared. Results of this examinations reveals that expression of D3 receptor is increased in compared with controls sample.

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Microfluidic PCR device for diagnostic pathogen detection
Johannes R. Peham, Hannes Steiner, Walter Grienauer, Rudolf Heer, Michael J. Vellekoop, Christa Nöhammer, Herbert Wiesinger

In this work a microfluidic cyclic flow PCR device is presented, which is capable of replicating the bacterial genomic DNA sequence of the 16S ribosomal RNA. The standard laboratory processing time of 3 h could be decreased to 60 min with the microfluidic reactor without loosing PCR efficiency. Integrating an optical fluorescence detector for dsDNA measurement would evolve this device into a micro total analysis system.

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Knowledge of personal energy requirements in college students
Aurora Buffington, MS, RD, Richard Tandy, PhD, and Laura Kruskall, PhD, RD, CSSD, FACSM

This study explored whether university students were able to estimate their energy requirements within a range of calories equal to predicted Estimated Energy Requirements (EER) two standard deviations. Students significantly underestimated their EER by 700 calories (p<.001). Fewer males than expected were able to estimate energy requirements as compared to females, 41.3% vs. 20.6%, ?2 (1) = 7.236, p=.007.

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No Impact of Dietary Iodine Restriction in Short Term Development of Hypothyroidism Following Fixed Dose Radioactive Iodine Therapy for Graves Disease
Jubbin J Jacob*, Charles Stephen§, Nihal Thomas*, Regi Oommen¶ and M.S.Seshadri*

To study the outcomes at 6 months after fixed dose 131I therapy for Graves’ disease (GD) with an iodine restricted diet.

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Nutritionally-induced differences in the metabolic profiles of Chlamydomonas reinhardtii and Saccharomyces cerevisae determined by 1H-NMR and cross model validation and permutation testing
Hank D. Bestman & Jordyn B. Brandsma

Using cross validation, permutation and rank products statistical procedures we identified biomarker regions in proton spectra of polar metabolites extracted from the algae Chlamydomonas reinhardtii (light and dark grown) and from the yeast Saccharomyces cerevisae (aerobically and anaerobically grown).

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Adaptive control of glycerol & methanol feeding in recombinant Pichia pastoris cultures: Impact on antibody titre
Filipe Ataíde, Ana Raquel Ferreira, João J. Clemente, António E. Cunha, Rui Oliveira

Pichia pastoris processes for heterolougous protein expression are typically run in three phases: a batch phase, an exponential feeding fed-batch phase and a long oxygen transfer limitation (OTL) phase. The final protein titre is often limited by the oxygen availability in the OTL phase. Here a direct adaptive controller is designed for the OTL phase. The controller was validated in pilot P. pastoris cultivations expressing a single chain antibody fragment (ScFv). This work shows that the propos

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Genetic Algorithms Successfully Select Potential Biomarkers in Mass Spectrometry-Based Metabolomics
Wei Zou, Vladimir Tolstikov

Combination of the comprehensive metabolic profiling utilizing three complementary analytical methods for MS data acquisition and Genetic Algorithms technique for feature selection presenting intriguing avenue for finding and exploration small subsets of strong classifiers.

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Showing Results 31 - 40 of 62
Scientific News
Light-activated Drug Could Reduce Side Effects of Diabetes Medication
Scientists have created a drug for type 2 diabetes that is switched on by blue light, which they hope will improve treatment of the disease.
Getting Metabolism Right
Analysis of 89 models of metabolic processes finds flaws in 44 of them — but suggests corrections.
Biologists Find An Early Sign Of Cancer
Patients show boost in certain amino acids years before diagnosis of pancreatic cancer.
Comparison of Caffeinated and Decaffeinated Coffee - Implications for Alzheimer's Disease
Researchers from the National University of Singapore successfully demonstrated the viability of GC-TOF-MS as an analytical platform for metabolomics analysis of coffee samples.
Single Enzyme is Necessary for Development of Diabetes
12-LO enzyme promotes the obesity-induced oxidative stress in the pancreatic cells.
A New Player in Lipid Metabolism Discovered
Specially engineered mice gained no weight, and normal counterparts became obese on the same high-fat, obesity-inducing Western diet.
UT Southwestern Researchers Uncover New Brain Pathways
New therapies for treating Type 2 diabetes and obesity.
Mass Spec-Based Metabolomics Workflows to Evaluate Plant Immunity
This article reviews metabolomics studies used to evaluate plant immunity with an emphasis on mass spectrometry in its many forms.
Assessing Anticancer Drugs Efficacy by Amino Acid Metabolomics
Researchers aimed to develop a method that determines the therapeutic efficacy of anticancer drugs based on the changes in amino acid metabolism at the cellular level.
Time Of Day Crucial to Accurately Test for Diseases
A new study published in PNAS has found that time of day and sleep deprivation have a significant effect on our metabolism.
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