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The Human Serum Metabolome
Nick Psychogios, David Hau, Jun Peng, Igor Sinelnikov, Souhaila Bouatra, Rupasri Mandal, Ram Krishna Murthy, Jianguo Xia, Fiona Bamforth, Janet McManus, Theresa Pedersen, Russ Greiner, Bruce McManus, John Newman and David Wishart

As part of our objective to systematically characterize the human metabolome and advance the fields of quantitative metabolomics, we present a global metabolic profiling of the human serum. Our experimental results indicated that global metabolic profiling methods can routinely detect more than 4200 different compounds in serum.

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Comparison of In Vivo and In Vitro 1-H NMR Spectroscopy in the Rat Brain: Technical Considerations, Effects of Brain Regions and Post Weaning Isolation
Philippine C. Geiszler, A. Napolitano, M.I. Schubert, C.A. Jones, K.C.F. Fone, C.A. Daykin, D.P. Auer

In vivo and in vitro magnetic resonance (MR) spectroscopy are both used to obtain complementary information about the metabolic state of living tissue/tissue extracts, respectively. However, comparisons between in vivo and in vitro measurements are rare. The aim of this study was to compare results from in vivo and in vitro MR spectroscopy to study inter-regional variations and the effects of social isolation on metabolite levels in rat brain.

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Mass-Spectrometric Analysis with Sequenom EpiTYPER of GNAS Methylation in Pseudohypoparathyroydism Type Ib Patients Reveals Overall Methylation Defects also for the Familial Cases
Benedetta Izzi1, Bart Claes2, Diether Lambrechts2, Chris Van Geet1,3, Kathleen Freson1

Sequenom EpiTYPER analysis of GNAS methylation in Pseudohypoparathyroidism type Ib patients reveals overall GNAS methylation defects also for the familial cases. Such abnormalities are not detectable via old methodologies such as PCR followed by methylation specific restriction digestion and are here for the first time described.

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MicroRNA-23b negatively regulates urokinase and c-met and inhibits migration of human hepatocellular carcinoma cells.
Salvi A, Sabelli C, Moncini S, Venturin M, Arici B ,Riva P, Portolani N, Giulini SM, Barlati S and De Petro G.

By bioinformatics we predicted that miR-23b could recognize two sites in the 3’ UTR of uPA (urokinase-type plasminogen activator) and four sites in the 3’ UTR of c-met (hepatocyte growth factor receptor). miR-23b transfections in SKHep1C3 caused uPA and c-met decreased and migration and proliferation inhibition of SKHep1C3; anti-miR-23b transfection in human fibroblasts upregulated uPA and c-met. uPA and c-met shared a common microRNA that negatively regulates their expression.

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Interactive Metabolomics by Diffusion NMR: Improving the Odds of Finding Needles in Haystacks
Jonathan Byrne, Rasmus Bro, Florian Wulfert and Clare A. Daykin

Metabolomics investigates changes in quantities of metabolites. However, blood plasma is a complex, heterogeneous mixture of components which undergo a variety of possible molecular interactions. In particular, many low molecular weight compounds (including drugs) can exist both ‘free’ in solution, bound to proteins or within organised aggregates of macromolecules. To study the effects of e.g. disease on these interactions we have developed a technique termed ‘interactive metabolomics’.

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A compartmented in silico model of Rapeseed central metabolism
Eleftherios Pilalis, Aristotelis Chatziioannou, Fragiskos Kolisis

A large-scale in silico model was constructed for the simulation of the central metabolism of Rapeseed embryos. In order to validate this model, we performed constraint-based Flux Balance Analysis, through application of linear optimization methods. Further exploiting the derived model, an in silico gene deletion analysis and a systemic regulatory analysis by Singular Value Decomposition of the steady-state flux space were performed.

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SYBR® Green I as a biomarker for schizophrenia
Davood Zaeifi, Mehdi Rahmati, Vahab Piranfar

The purpose of this study were to examine if the mRNA of the peripheral dopamine receptor is changed in schizophrenia patients. 50 Naive patients were enrolled. After extracting RNA from white blood cells, cDNA is synthesized. After doing the quantitative Real-time PCR, expression of D3 receptors in healthy persons and patients were compared. Results of this examinations reveals that expression of D3 receptor is increased in compared with controls sample.

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Microfluidic PCR device for diagnostic pathogen detection
Johannes R. Peham, Hannes Steiner, Walter Grienauer, Rudolf Heer, Michael J. Vellekoop, Christa Nöhammer, Herbert Wiesinger

In this work a microfluidic cyclic flow PCR device is presented, which is capable of replicating the bacterial genomic DNA sequence of the 16S ribosomal RNA. The standard laboratory processing time of 3 h could be decreased to 60 min with the microfluidic reactor without loosing PCR efficiency. Integrating an optical fluorescence detector for dsDNA measurement would evolve this device into a micro total analysis system.

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Knowledge of personal energy requirements in college students
Aurora Buffington, MS, RD, Richard Tandy, PhD, and Laura Kruskall, PhD, RD, CSSD, FACSM

This study explored whether university students were able to estimate their energy requirements within a range of calories equal to predicted Estimated Energy Requirements (EER) two standard deviations. Students significantly underestimated their EER by 700 calories (p<.001). Fewer males than expected were able to estimate energy requirements as compared to females, 41.3% vs. 20.6%, ?2 (1) = 7.236, p=.007.

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Scientific News
Molecule Hijacks Enzyme To Boost Alcohol Metabolism
Study could lead to treatments for people with impaired acetaldehyde metabolism.
Bacterial Memories – Host influences Bacterial Metabolism
Study shows bacteria have some sort of memory.
Possible Neuron Killing Mechanism Behind Alzheimer’s and Parkinson’s Diseases Discovered
$1.4 million grant will enable team to follow up with search for drug candidates.
Microbes Prevent Malnutrition in Fruit Flies—and Maybe Humans, Too
Study shows that microbes play a critical role in nutritional disorders.
Researchers Find Link Between Microbiome, Type 1 Diabetes
Largest longitudinal study to date sees shift in microbiome species diversity prior to onset of disease.
New Metabolic Biomarkers Predict Future Cardiovascular Diseases
Scientists of the Helmholtz Zentrum München contributed to the analysis of the biomarkers.
Metabolic Mystery Solved, Lending Insight Into Lafora Disease
Scientists at the University of Kentucky College of Medicine have determined how an enzyme essential for energy metabolism functions, solving a mystery eluding molecular biologists for decades.
First Major Analysis Of Human Protein Atlas Published
A research article published in Science presents the first major analysis based on the Human Protein Atlas, including a detailed picture of the proteins that are linked to cancer, the number of proteins present in the bloodstream, and the targets for all approved drugs on the market.
Chestnuts Roasting On An Open Fire
ORNL work with scientists funded by The American Chestnut Foundation confirms increased blight-resistance of former forest giant.
Metabolomics Data Normalization with EigenMS
In this study, a singular value decomposition-based method, called EigenMS, for normalization of metabolomics data was tested.
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