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No Impact of Dietary Iodine Restriction in Short Term Development of Hypothyroidism Following Fixed Dose Radioactive Iodine Therapy for Graves Disease
Jubbin J Jacob*, Charles Stephen§, Nihal Thomas*, Regi Oommen¶ and M.S.Seshadri*

To study the outcomes at 6 months after fixed dose 131I therapy for Graves’ disease (GD) with an iodine restricted diet.

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Nutritionally-induced differences in the metabolic profiles of Chlamydomonas reinhardtii and Saccharomyces cerevisae determined by 1H-NMR and cross model validation and permutation testing
Hank D. Bestman & Jordyn B. Brandsma

Using cross validation, permutation and rank products statistical procedures we identified biomarker regions in proton spectra of polar metabolites extracted from the algae Chlamydomonas reinhardtii (light and dark grown) and from the yeast Saccharomyces cerevisae (aerobically and anaerobically grown).

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Adaptive control of glycerol & methanol feeding in recombinant Pichia pastoris cultures: Impact on antibody titre
Filipe Ataíde, Ana Raquel Ferreira, João J. Clemente, António E. Cunha, Rui Oliveira

Pichia pastoris processes for heterolougous protein expression are typically run in three phases: a batch phase, an exponential feeding fed-batch phase and a long oxygen transfer limitation (OTL) phase. The final protein titre is often limited by the oxygen availability in the OTL phase. Here a direct adaptive controller is designed for the OTL phase. The controller was validated in pilot P. pastoris cultivations expressing a single chain antibody fragment (ScFv). This work shows that the propos

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Genetic Algorithms Successfully Select Potential Biomarkers in Mass Spectrometry-Based Metabolomics
Wei Zou, Vladimir Tolstikov

Combination of the comprehensive metabolic profiling utilizing three complementary analytical methods for MS data acquisition and Genetic Algorithms technique for feature selection presenting intriguing avenue for finding and exploration small subsets of strong classifiers.

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Bio-analytic silicon chips for the detection of developmentalneurotoxic effects of chemicals and drugs in the context of the European REACH program
S. Buehler , Helene Altrichter , P. J. Koester , C. Tautorat , Ralf Ehret ,Werner Baumann , Jan Gimsa

Bio-analytic silicon chips can be used to investigate stem cell differentiation into neurons and for the in vitro on-line monitoring of cellular reactions under well controlled experimental conditions. Chip systems allow for a parallel, label-free and non-invasive measurement of different parameters by CMOS silicon microsensors by the application of potential neurotoxic and developmental neurotoxic substances.

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Bio-analytic silicon chips for the detection of developmentalneurotoxic effects of chemicals and drugs in the context of the European REACH program
S. Buehler , Helene Altrichter , P. J. Koester , C. Tautorat , Ralf Ehret ,Werner Baumann , Jan Gimsa

Bio-analytic silicon chips can be used to investigate stem cell differentiation into neurons and for the in vitro on-line monitoring of cellular reactions under well controlled experimental conditions. Chip systems allow for a parallel, label-free and non-invasive measurement of different parameters by CMOS silicon microsensors by the application of potential neurotoxic and developmental neurotoxic substances.

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Biomarkers and Metabolomics: Practical Implication
Vladimir V. Tolstikov

Current presentation is dedicated to case studies and illustrates diversity of the projects. Cases representing different projects combine the same analytical platform we utilize for metabolomics study of blood plasma and urine. While pattern recognition presents certain challenges but rather ones that can be resolved, identification of low abundant unknown biomarkers is critical for the field and offers significant technical challenge in spite of considerable progress in modern analytical techn

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Biomarkers and Metabolomics: Practical Implication
Vladimir V. Tolstikov

Current presentation is dedicated to case studies and illustrates diversity of the projects. Cases representing different projects combine the same analytical platform we utilize for metabolomics study of blood plasma and urine. While pattern recognition presents certain challenges but rather ones that can be resolved, identification of low abundant unknown biomarkers is critical for the field and offers significant technical challenge in spite of considerable progress in modern analytical techn

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PRIMe: Platform for RIKEN Metabolomics
Atsushi Fukushima, Miyako Kusano, Kenji Akiyama, Takeshi Obayashi, Takayuki Tohge, Masami Yokota Hirai, Shigehiko Kanaya, Masanori Arita, Yoko Shinbo, Kazuo Shinozaki, Tetsuya Sakurai and Kazuki Saito

We have developed a web-based database, "PRIMe (Platform for RIKEN Metabolomics)," which contains powerful tools for researchers to analyze gene co-expression data and mass spectral data. PRIMe has been developed with the main aim of facilitating integrated analysis for transcriptomics and metabolomics.

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Showing Results 41 - 50 of 67
Scientific News
Giant Panda Microbiome Poorly Adapted for a Bamboo Diet
Researchers have found that the microbiome of the Giant Panda lacks key bacterial species typically found in herbivores.
Infant Antibiotic use Linked to Adult Diseases
A new study has found a three-way link among antibiotic use in infants, changes in the gut bacteria and disease later in life.
Potential Forensic Uses for Human Microbiome
A recent study suggests microbial communities found on or in some sites in an individual's body can be used as fingerprint-like identifiers.
Ease of Weight Loss Influenced by Individual Biology
NIH study finds varied responses to calorie restriction in obese adults.
LECO Announces Special Events at ASMS
Company to host a series of events during the conference held at the America’s Center, Saint Louis, MO on May 31-June 4.
Metabolic Link Discovered Between Colon Cancer and Bacterial Biofilms
A research team writes in Cell Metabolism that they have uncovered a clue to how bacteria may promote some colon cancers.
Blood Markers Could Help Predict Outcome Of Infant Heart Surgery
New research suggests it may be possible to predict an infant’s progress following surgery for congenital heart disease by analysing a number of important small molecules in the blood.
Scherer to Receive Banting Medal for Diabetes Research
Medal recognizes significant, long-term contributions to the understanding, treatment, or prevention of diabetes.
Urine Profiles Provide Clues To How Obesity Causes Disease
Scientists have identified chemical markers in urine associated with body mass, providing insights into how obesity causes disease.
Cells Exercise Suboptimal Strategy to Survive
Rice University study shows it’s not always good for cells’ metabolism to work at peak efficiency.
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