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Towards Understanding of Ryegrass-Endophyte Symbiosis through Data Integration of Transcriptome and Metabolome
Mingshu Cao, Linda Johnson, Albert Koulman, Geoff Lane and Susanne Rasmussen

Combined with extensive bioinformatics analyses, our joint analysis of transcriptomics and metabolomics data has generated interesting findings which led to further laboratory verification, such as potential genes associated with alkaloid production.

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Ethnopharmacological Evaluation of Radal (leaves of Lomatia hirsuta) through Metabolite Profiling and Isolation of 2-Methoxyjuglone.
Henrik Toft Simonsena, Louise Berthelsenb, Anne Adsersenb, Søren Brøgger Christensenb, Alfonso Guzmánb and Per Mølgaardb

To evaluate the efficacy of the traditionally used herbal remedy Radal a metabolite profile of the original plant material was established. The EtOAc extract of the leaves and found to be active against the pathogenic fungus Candida albicans (MIC = 8 µg/ml). Cinnamic acid (2) and vanillic acid (5) were identified as the major constituents in the tea by GC-MS along with other phenolic derivatives.

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The Comparison of Lipid Extraction Methods for the Lipidomic Analysis of Human Blood Plasma
Ali Awwad, Catharine Ortori, Dave A. Barrett and Clare A. Daykin

Although metabolomics is and should remain an integrated approach by itself, its complexity requires analogous approaches focused on its components, such as lipidomics. Lipid profiling by NMR without sample extraction, should be seen as only the first stage in lipidomic analysis. Subsequent analysis should involve extraction of the lipids from the biofluid or tissue prior to further profiling using a multi-technique metabolomic approach involving both NMR and MS.

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Profiling of Urinary Metabolites
Vladimir V. Tolstikov, Tobias Kind, Kindra D. Brooks and Robert H. Weiss

Urine samples from healthy individuals and kidney cancer patients were used for metabolic profiling method development and for urine metabolome analysis.

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Biomarker Identification Combining Multivariate Analysis of NMR Spectra with an Innovative Spectral Data Analysis Approach in an Integrated Working Environment
Regis Grenier, Yann Bidault, Chen Peng, Gregory M. Banik, Scott Ramos, Brian Rohrback, Tao Wang and Bin Xia,

A recently developed Metabolomics informatics solution from raw data processing to metabolite database searching, compatible with multiple instruments, has been successfully applied to the analysis of 1H NMR human serum spectra of diabetic and non-diabetic subjects. This study also highlights Overlap Density Heatmap, a novel technology that complements the use of chemometrics in biomarker identification.

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Constructing Directed Metabolic Networks from Microarray Data
J. M. Easton, T. N. Arvanitis, A. Peet and M. Viant

Although it has been several years since metabolic networks became a commonly used analysis technique in bioinformatics, the question of how best to construct them from experimental data is still not satisfactorily resolved. Here we present a method for the construction of directed metabolic networks from microarray datasets using an enhanced version of the KEGG LIGAND database.

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Application of 1H NMR Metabolomics to a Murine Model of Inflammatory Arthritis
Reza Dowlatabadi, B. Joan Miller, Frank R. Jirik, Hans J. Vogel and Aalim M. Weljie

The novel quantitative technique of "Targeted Profiling" of 1H 1D NMR data is applied to a unique model of rheumatoid arthritis. A number of candidate biomarkers not previously identified using NMR techniques are identified related to inflammation and immune response. The pharmaceutical relevance of several of these metabolites is discussed.

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Herbal Metabolic Profiling of Raw and Steamed Panax notoginseng
Eric C.Y. Chan, Swee-Lee Yap, Aik-Jiang Lau, Pay-Chin Leow, Ding-Fung Toh, and Hwee-Ling Koh

At present, metabolite profiling is of growing importance in herbal medicine fields such as breeding, formulation, quality control and clinical trials. Herbal metabolic profiling allows direct detection of down-stream derivatives of metabolites, arising from herbal formulation process, using metabolite profiling ultra performance liquid chromatography time-of-flight mass spectrometry.

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Metabolic Profiling of Human Blood Plasma by Combined Ultra Performance Liquid Chromatography / Mass Spectrometry
Steve Bruce, Pär Jonsson, Henrik Antti, Olivier Cloarec, Stefan Marklund and Thomas Moritz

Metabolic profiling is concerned with the analysis of low molecular weight compounds present in complex samples such as plasma. Analytical techniques such as UPLC/MS are proving to be powerful tools for metabolic profiling on complex samples such as plasma. Here we describe a protocol of metabolic profiling analysis on plasma by UPLC/MS.

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Showing Results 51 - 60 of 66
Scientific News
New Metabolic Biomarkers Predict Future Cardiovascular Diseases
Scientists of the Helmholtz Zentrum München contributed to the analysis of the biomarkers.
Metabolic Mystery Solved, Lending Insight Into Lafora Disease
Scientists at the University of Kentucky College of Medicine have determined how an enzyme essential for energy metabolism functions, solving a mystery eluding molecular biologists for decades.
First Major Analysis Of Human Protein Atlas Published
A research article published in Science presents the first major analysis based on the Human Protein Atlas, including a detailed picture of the proteins that are linked to cancer, the number of proteins present in the bloodstream, and the targets for all approved drugs on the market.
Chestnuts Roasting On An Open Fire
ORNL work with scientists funded by The American Chestnut Foundation confirms increased blight-resistance of former forest giant.
Metabolomics Data Normalization with EigenMS
In this study, a singular value decomposition-based method, called EigenMS, for normalization of metabolomics data was tested.
Circadian Variation Of The Human Metabolome
Real-time breath analysis was used to study circadian metabolism.
Discovery Links Shift In Metabolism To Stem Cell Renewal
Mouse cells exposed to the metabolite alpha-ketoglutarate became more likely to renew themselves.
Bridging Quantitative Analysis and Untargeted Metabolomics
Untargeted metabolomics has become a popular tool in metabolite biomarker discovery and in the evaluation of metabolic pathway changes associated with disease.
Light-activated Drug Could Reduce Side Effects of Diabetes Medication
Scientists have created a drug for type 2 diabetes that is switched on by blue light, which they hope will improve treatment of the disease.
Getting Metabolism Right
Analysis of 89 models of metabolic processes finds flaws in 44 of them — but suggests corrections.
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