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 | A Genome-wide Look at Post-Transcriptional Gene Regulation Jason Myers, Ion Torrent Systems Incorporated, speaking at Genomics Research Asia 2012 |
 | Computational Analysis of Cancer Epigenome and Transcriptome Kaifu Chen, Baylor College of Medicine, speaking at Genomics Research 2013. |
Benchtop Automation Trends 2013
HTStec
This market report summarizes the results of HTStec's industry-wide global web-based benchmarking survey on small-scale or benchtop automation carried out in January 2013.
Next-Gen Sequencing Trends 2012
HTStec
This market report summarizes the results of HTStec’s 3rd industry-wide global web-based benchmarking survey on next-generation sequencing (NGS) carried out in November 2012.
Single Cell Technologies Trends
HTStec
This market report summarizes the results of HTStec’s industry-wide global web-based benchmarking survey on single cell technologies carried out in June 2012.
Next Generation Sequencing (NGS) Market
MarketsandMarkets
by technology (pyrosequencing & others), competitors (Illumina, 454 Roche, Life Science Technologies), applications & tools - global trends & forecasts (2011 – 2016)
Life Science and Chemical Instrumentation Market (2011 - 2016)
MarketsandMarkets
Spectroscopy, Chromatography, DNA Sequencer & Amplifier, Lab Automation, Array, Flow Cytometer, Electrophoresis, Immuno Assay & Others
High Throughput qPCR Assay Trends
HTStec
This market report summarizes the results of HTStec’s global web-based benchmarking survey on high throughput real-time quantitative PCR (HT qPCR) assays carried out in January 2012.
Biochips Market (DNA Microarrays, Lab-on-Chip, Protein Microarrays, Tissue & Cell Arrays) Trends & Global Forecast (2010-2015)
MarketsandMarkets
The global biochip market is studied by the types and key applications. It was valued at $2.6 billion in 2010 and is expected to reach $5.6 billion by 2015; growing at a CAGR of 16.7%. This growth is attributed to increasing applications in cancer diagnostics and expression profiling, the boom in personalized medicine, and government funding.
Next-Gen Sequencing Trends 2011
HTStec
This market report summarizes the results of HTStec’s 2nd industry-wide global web-based benchmarking survey on next-generation sequencing (NGS) carried out in March 2011.
The Future of Molecular Diagnostics: Innovative technologies driving market opportunities in personalized medicine
Business Insights
This report analyzes the current and potential world markets for molecular diagnostics, including advances in the field. This report generally forecasts future growth to 2015. The report breaks down market forecasts by type of test and by geography. It indicates which companies have key products in the market place. It also analyzes key drivers of this market.
HTStec
This market report summarizes the results of HTStec's industry-wide global web-based benchmarking survey on small-scale or benchtop automation carried out in January 2013.
Next-Gen Sequencing Trends 2012
HTStec
This market report summarizes the results of HTStec’s 3rd industry-wide global web-based benchmarking survey on next-generation sequencing (NGS) carried out in November 2012.
Single Cell Technologies Trends
HTStec
This market report summarizes the results of HTStec’s industry-wide global web-based benchmarking survey on single cell technologies carried out in June 2012.
Next Generation Sequencing (NGS) Market
MarketsandMarkets
by technology (pyrosequencing & others), competitors (Illumina, 454 Roche, Life Science Technologies), applications & tools - global trends & forecasts (2011 – 2016)
Life Science and Chemical Instrumentation Market (2011 - 2016)
MarketsandMarkets
Spectroscopy, Chromatography, DNA Sequencer & Amplifier, Lab Automation, Array, Flow Cytometer, Electrophoresis, Immuno Assay & Others
High Throughput qPCR Assay Trends
HTStec
This market report summarizes the results of HTStec’s global web-based benchmarking survey on high throughput real-time quantitative PCR (HT qPCR) assays carried out in January 2012.
Biochips Market (DNA Microarrays, Lab-on-Chip, Protein Microarrays, Tissue & Cell Arrays) Trends & Global Forecast (2010-2015)
MarketsandMarkets
The global biochip market is studied by the types and key applications. It was valued at $2.6 billion in 2010 and is expected to reach $5.6 billion by 2015; growing at a CAGR of 16.7%. This growth is attributed to increasing applications in cancer diagnostics and expression profiling, the boom in personalized medicine, and government funding.
Next-Gen Sequencing Trends 2011
HTStec
This market report summarizes the results of HTStec’s 2nd industry-wide global web-based benchmarking survey on next-generation sequencing (NGS) carried out in March 2011.
The Future of Molecular Diagnostics: Innovative technologies driving market opportunities in personalized medicine
Business Insights
This report analyzes the current and potential world markets for molecular diagnostics, including advances in the field. This report generally forecasts future growth to 2015. The report breaks down market forecasts by type of test and by geography. It indicates which companies have key products in the market place. It also analyzes key drivers of this market.
DNA Sequencing Reveals Mucosal Melanoma's Bullseye
Scientists have found a molecular 'bullseye' for a rare form of melanoma, opening up opportunities for new targeted treatment.
Genome Offers Clues to Amphibian-Killing Fungus
A fungus that has decimated amphibians globally is much older than previously thought.
Researchers Identify First Drug Targets in Childhood Genetic Tumor Disorder
Genetic mutations may be targeted by currently available cancer therapies.
NIH Researchers Conduct First Genomic Survey of Human Skin Fungal Diversity
Location on the body surface determines fungal composition with the greatest diversity on feet.
New DNA Cattle Test Beefs up Dairy and Meat Quality
A genomics technique developed at Cornell to improve corn can now be used to improve the quality of milk and meat.
TATAA Strengthens Quality Assurance Program
TATAA Biocenter expands offerings using AATI’s Fragment Analyzer™ to assess RNA quality in gene expression analysis.
A Cautionary Tale on Genome-Sequencing Diagnostics for Rare Diseases
Studies in several children have raising new questions about inheritance, genomic sequencing, and diagnostic.
Gene Identified Responsible for Disorders of Bones and Connective Tissue
Researchers have identified a gene that when mutated is responsible for a spectrum of disorder.
Genetic Study Shows Europeans are One Big Family
Europeans are basically one big family, closely related to one another for the past thousand years, according to a new study of the DNA of people from across the continent.
Genome Sequencing Provides Unprecedented Insight into Causes of Pneumococcal Disease
Technology will allow better surveillance of bacterial populations, understanding of vaccine effectiveness.
Scientists have found a molecular 'bullseye' for a rare form of melanoma, opening up opportunities for new targeted treatment.
Genome Offers Clues to Amphibian-Killing Fungus
A fungus that has decimated amphibians globally is much older than previously thought.
Researchers Identify First Drug Targets in Childhood Genetic Tumor Disorder
Genetic mutations may be targeted by currently available cancer therapies.
NIH Researchers Conduct First Genomic Survey of Human Skin Fungal Diversity
Location on the body surface determines fungal composition with the greatest diversity on feet.
New DNA Cattle Test Beefs up Dairy and Meat Quality
A genomics technique developed at Cornell to improve corn can now be used to improve the quality of milk and meat.
TATAA Strengthens Quality Assurance Program
TATAA Biocenter expands offerings using AATI’s Fragment Analyzer™ to assess RNA quality in gene expression analysis.
A Cautionary Tale on Genome-Sequencing Diagnostics for Rare Diseases
Studies in several children have raising new questions about inheritance, genomic sequencing, and diagnostic.
Gene Identified Responsible for Disorders of Bones and Connective Tissue
Researchers have identified a gene that when mutated is responsible for a spectrum of disorder.
Genetic Study Shows Europeans are One Big Family
Europeans are basically one big family, closely related to one another for the past thousand years, according to a new study of the DNA of people from across the continent.
Genome Sequencing Provides Unprecedented Insight into Causes of Pneumococcal Disease
Technology will allow better surveillance of bacterial populations, understanding of vaccine effectiveness.
Source BioScience Launches New Overnight Service for DNA Sequencing
Overnight service offers free sample collection and rapid delivery of results in Scotland.
Life Technologies Acquires Life Science Korea
The acquisition strengthens Life Tech's go-direct strategy in South Korea.
Global Alliance to Enable Secure Sharing of Genomic and Clinical Data
Over 70 leading organizations have taken the first steps to form an international alliance dedicated to enabling secure sharing of genomic and clinical data.
Arrayjet Continue to Widen Global Sales Channels with New Distribution Deal
Arrayjet appoint Sciencewerke Pte Ltd as a distributor in South East Asia.
Mayo Clinic Forms Joint Venture with Cancer Genetics
OncoSpire Genomics will seek to discover and commercialize biomarkers for multiple cancer types.
Surveying Cells, One At a Time
When studying any kind of population — people or cells — averaging is a useful, if flawed, form of measurement.
SYGNIS Reports Results for the First Quarter of 2013
Company announced that operating expenses have decreased by more than 50 percent and that operating result is significantly improved.
Illumina Announces Partnerships to Automate TruSeq® and Nextera® Sample Preparation Kits
Automation methods developed by leading vendors will enable customers to accelerate testing and discovery.
Selventa Strengthens Intellectual Property for SysDx™ Approach to Personalized Medicine
Patent is core to Selventa’s SysDx™ approach to mining and comparing biological data for predicting a patient’s response or non-response to a drug.
Foundation Medicine and Memorial Sloan-Kettering Cancer Center Announce Partnership
Partners will co-develop a genomic test to help guide treatment decisions for patients diagnosed with leukemia, lymphoma or myeloma.
Overnight service offers free sample collection and rapid delivery of results in Scotland.
Life Technologies Acquires Life Science Korea
The acquisition strengthens Life Tech's go-direct strategy in South Korea.
Global Alliance to Enable Secure Sharing of Genomic and Clinical Data
Over 70 leading organizations have taken the first steps to form an international alliance dedicated to enabling secure sharing of genomic and clinical data.
Arrayjet Continue to Widen Global Sales Channels with New Distribution Deal
Arrayjet appoint Sciencewerke Pte Ltd as a distributor in South East Asia.
Mayo Clinic Forms Joint Venture with Cancer Genetics
OncoSpire Genomics will seek to discover and commercialize biomarkers for multiple cancer types.
Surveying Cells, One At a Time
When studying any kind of population — people or cells — averaging is a useful, if flawed, form of measurement.
SYGNIS Reports Results for the First Quarter of 2013
Company announced that operating expenses have decreased by more than 50 percent and that operating result is significantly improved.
Illumina Announces Partnerships to Automate TruSeq® and Nextera® Sample Preparation Kits
Automation methods developed by leading vendors will enable customers to accelerate testing and discovery.
Selventa Strengthens Intellectual Property for SysDx™ Approach to Personalized Medicine
Patent is core to Selventa’s SysDx™ approach to mining and comparing biological data for predicting a patient’s response or non-response to a drug.
Foundation Medicine and Memorial Sloan-Kettering Cancer Center Announce Partnership
Partners will co-develop a genomic test to help guide treatment decisions for patients diagnosed with leukemia, lymphoma or myeloma.
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High-Throughput Analysis of DNA Samples using the D1K ScreenTape Assay and the Agilent 2200 TapeStation System
Agilent Technologies
Recent advances in genomics demands to look at a wealth of genetic information in a short period of time. DNA analysis using slab gel electrophoresis and capillary electrophoresis are widely being used as a QC step in next generation sequencing and microarray studies. However, often these techniques lack the speed and involve more manual steps to perform the assay.
Improved Ligation Specificity with Chemically Modified Ligation Components
TriLink BioTechnologies, Inc.
Ligases are gaining utility in molecular biology applications, such as nucleotide sequence detection, single nucleotide polymorphism (SNP) detection, protein detection and “next generation” sequencing by ligation.
Defining off-target cleavage in a pair of Zinc Finger Nucleases
University of Utah
This study looks at off-target cleavage of Zinc Finger Nucleases (ZNFs) in Drosophila in an attempt to analyze potential cleavage spots, with a view to designing more efficient ZFNs.
Efficacy of Using a Combination Microplate Washer for Vacuum-Based DNA Sequencing Reaction Cleanup
BioTek Instruments
The ability to determine the specific pattern of base pairs in DNA molecules is an indispensable part of contemporary molecular biology. This poster demonstrates how the vacuum filtration module available on the BioTek 405 Touch effectively cleans contaminating artifacts from DNA sequencing reactions, which wil contribute to the genomic workflow typical of many molecular biology laboratories and core facilities.
DNA Methylation Analysis – Reliable Cell Characterization in Regenerative Medicine
Epiontis GmbH and Genzyme Biosurgery
We demonstrate that DNA methylation patterns can serve as characteristic markers to distinguish different cell types. We have identified panels of methylation markers that are specific to mesenchymal stem cells or various differentiated cell types in the mesenchymal lineage. This method of cell type identification has a number of advantages over conventional markers in that it is robust, is both qualitative and quantitative.
EasyBeacons™ - new Probes Ideal for Realtime PCR Detection of Methylation Status of Single CpG Duplets and SNPs
PentaBase
The EasyBeacons™ presented here are based on the novel technology Intercalating Nucleic Acid, INA®, linked to a fluorophore and a quencher. INA® is composed of normal DNA nucleotides and Intercalating Pseudo Nucleotides (IPNs). The fact that the EasyBeacons™ are mostly composed of normal DNA nucleotides means that in many respects EasyBeacons™ behave like DNA based probes, allowing use of standard buffers, primers and enzymes and hence reduces the optimisation efforts.
Utilizing High Speed Photography to Optimize Low Volume Dispensing Conditions
Innovadyne Technologies, Inc
In this study we use high-speed photography as a feedback mechanism for adjusting the Nanodrop instrument dispense settings to improve the positional dispense accuracy of low volume (nanoliter) drops. These same parameters can be investigated, with various fluid classes, to reduce deleterious effects on dispensing performance such as deflected streams, satellite formation, secondary pulses and drop deformation.
Agilent Technologies
Recent advances in genomics demands to look at a wealth of genetic information in a short period of time. DNA analysis using slab gel electrophoresis and capillary electrophoresis are widely being used as a QC step in next generation sequencing and microarray studies. However, often these techniques lack the speed and involve more manual steps to perform the assay.
Improved Ligation Specificity with Chemically Modified Ligation Components
TriLink BioTechnologies, Inc.
Ligases are gaining utility in molecular biology applications, such as nucleotide sequence detection, single nucleotide polymorphism (SNP) detection, protein detection and “next generation” sequencing by ligation.
Defining off-target cleavage in a pair of Zinc Finger Nucleases
University of Utah
This study looks at off-target cleavage of Zinc Finger Nucleases (ZNFs) in Drosophila in an attempt to analyze potential cleavage spots, with a view to designing more efficient ZFNs.
Efficacy of Using a Combination Microplate Washer for Vacuum-Based DNA Sequencing Reaction Cleanup
BioTek Instruments
The ability to determine the specific pattern of base pairs in DNA molecules is an indispensable part of contemporary molecular biology. This poster demonstrates how the vacuum filtration module available on the BioTek 405 Touch effectively cleans contaminating artifacts from DNA sequencing reactions, which wil contribute to the genomic workflow typical of many molecular biology laboratories and core facilities.
DNA Methylation Analysis – Reliable Cell Characterization in Regenerative Medicine
Epiontis GmbH and Genzyme Biosurgery
We demonstrate that DNA methylation patterns can serve as characteristic markers to distinguish different cell types. We have identified panels of methylation markers that are specific to mesenchymal stem cells or various differentiated cell types in the mesenchymal lineage. This method of cell type identification has a number of advantages over conventional markers in that it is robust, is both qualitative and quantitative.
EasyBeacons™ - new Probes Ideal for Realtime PCR Detection of Methylation Status of Single CpG Duplets and SNPs
PentaBase
The EasyBeacons™ presented here are based on the novel technology Intercalating Nucleic Acid, INA®, linked to a fluorophore and a quencher. INA® is composed of normal DNA nucleotides and Intercalating Pseudo Nucleotides (IPNs). The fact that the EasyBeacons™ are mostly composed of normal DNA nucleotides means that in many respects EasyBeacons™ behave like DNA based probes, allowing use of standard buffers, primers and enzymes and hence reduces the optimisation efforts.
Utilizing High Speed Photography to Optimize Low Volume Dispensing Conditions
Innovadyne Technologies, Inc
In this study we use high-speed photography as a feedback mechanism for adjusting the Nanodrop instrument dispense settings to improve the positional dispense accuracy of low volume (nanoliter) drops. These same parameters can be investigated, with various fluid classes, to reduce deleterious effects on dispensing performance such as deflected streams, satellite formation, secondary pulses and drop deformation.
Molecular indexing for improved RNA-Seq analysis
Bioo Scientific
Most modern methods for nucleic acid analysis require the use of enzyme processing, such as DNA polymerase reactions, in the sample preparation or measurement steps. Although necessary, these enzymatic steps introduce errors in the form of incorrect sequence and misrepresented copy number. NEXTflex™ qRNA-Seq™ Kit from Bioo Scientific adds no additional steps to the work flow, costs no more than a conventional library preparation kit and increases the precision of downstream analysis.
An Integrated Solution to Simplify Library Preparation and Multiplexing for NimbleGen Sequence Capture
Bioo Scientific
The studies described herein demonstrate the capability of Bioo Scientific’s novel NEXTFlex™ DNA Pre-Capture Combo Library construction kits used in conjunction with the NimbleGen Sequence Capture technology to obtain high coverage comparative genomic data from a panel of human HapMap DNA samples.
Next Generation Sequencing Method for Illumina TruSeq DNA Sample Preparation Protocol on the Hamilton STAR
Hamilton
The purpose of the TruSeq sample preparation protocol is to add adapter sequences onto the ends of DNA fragments to generate multiplexed sequencing libraries. Good liquid handling is crucial for pipetting precise volumes for example for Agilent Bioanalyzer.
Tools for Enhancing Sequence Diversity and Reducing Bias in DNA-seq Library Preparation
Bioo Scientific
The generation of high quality next generation sequencing data begins with libraries that have the desired insert size and proper adapter ligation.
Sequence-Specific DNA Assay
Molecular Devices
The Threshold® system from Molecular Devices, together with the Immuno Ligand Assay (ILA) kit can be used to measure specific DNA sequences. Biotinylated or fluorescienated oligonucleotide probes, specific to the target sequence, anneal to the digested target DNA creating a probe-target hybrid which can then be detected and quantified against a standard curve, with pleasing results.
High Yield and Quality with Thermo Scientific Microtiter Deep Well 96 plates in KingFisher Flex Process
Thermo Fisher Scientific
The Thermo Scientific KingFisher Flex magnetic particle processor is specifically designed to automate the time-consuming sample preparation of proteins, nucleic acids and cells in 96-well plate formats.
Isolation and Purification of Genomic DNA and Viral RNA from Clinical Samples with Thermo Scientific KingFisher Flex
Thermo Fisher Scientific
The purification of DNA and RNA from clinical samples requires rapid and reliable processing of large quantities of samples. Automated purification of nucleic acids, proteins and cells with Thermo Scientific KingFisher Flex is a reproducible and high quality method, which produces excellent material for further analyses.
Rapid and Reproducible DNA Isolation from 1 ml of Whole Blood with Thermo Scientific KingFisher Flex
Thermo Fisher Scientific
This application note shows the benefits of KingFisher Flex by using genomic DNA isolation from blood as an example.
Optimization of the DNA Purification Protocol for the Thermo Scientific KingFisher Flex and BindIt 3.1 Software
Thermo Fisher Scientific
Purpose: Optimal quantity and quality of DNA with the magnetic particle based extraction technology. Method: Thermo Scientific KingFisher Flex magnetic particle processor and BindIt® 3.1 Software. Results: By simple optimization of the nucleic acid extraction protocol it is possible to achieve a great yield of high quality DNA.
Bioo Scientific
Most modern methods for nucleic acid analysis require the use of enzyme processing, such as DNA polymerase reactions, in the sample preparation or measurement steps. Although necessary, these enzymatic steps introduce errors in the form of incorrect sequence and misrepresented copy number. NEXTflex™ qRNA-Seq™ Kit from Bioo Scientific adds no additional steps to the work flow, costs no more than a conventional library preparation kit and increases the precision of downstream analysis.
An Integrated Solution to Simplify Library Preparation and Multiplexing for NimbleGen Sequence Capture
Bioo Scientific
The studies described herein demonstrate the capability of Bioo Scientific’s novel NEXTFlex™ DNA Pre-Capture Combo Library construction kits used in conjunction with the NimbleGen Sequence Capture technology to obtain high coverage comparative genomic data from a panel of human HapMap DNA samples.
Next Generation Sequencing Method for Illumina TruSeq DNA Sample Preparation Protocol on the Hamilton STAR
Hamilton
The purpose of the TruSeq sample preparation protocol is to add adapter sequences onto the ends of DNA fragments to generate multiplexed sequencing libraries. Good liquid handling is crucial for pipetting precise volumes for example for Agilent Bioanalyzer.
Tools for Enhancing Sequence Diversity and Reducing Bias in DNA-seq Library Preparation
Bioo Scientific
The generation of high quality next generation sequencing data begins with libraries that have the desired insert size and proper adapter ligation.
Sequence-Specific DNA Assay
Molecular Devices
The Threshold® system from Molecular Devices, together with the Immuno Ligand Assay (ILA) kit can be used to measure specific DNA sequences. Biotinylated or fluorescienated oligonucleotide probes, specific to the target sequence, anneal to the digested target DNA creating a probe-target hybrid which can then be detected and quantified against a standard curve, with pleasing results.
High Yield and Quality with Thermo Scientific Microtiter Deep Well 96 plates in KingFisher Flex Process
Thermo Fisher Scientific
The Thermo Scientific KingFisher Flex magnetic particle processor is specifically designed to automate the time-consuming sample preparation of proteins, nucleic acids and cells in 96-well plate formats.
Isolation and Purification of Genomic DNA and Viral RNA from Clinical Samples with Thermo Scientific KingFisher Flex
Thermo Fisher Scientific
The purification of DNA and RNA from clinical samples requires rapid and reliable processing of large quantities of samples. Automated purification of nucleic acids, proteins and cells with Thermo Scientific KingFisher Flex is a reproducible and high quality method, which produces excellent material for further analyses.
Rapid and Reproducible DNA Isolation from 1 ml of Whole Blood with Thermo Scientific KingFisher Flex
Thermo Fisher Scientific
This application note shows the benefits of KingFisher Flex by using genomic DNA isolation from blood as an example.
Optimization of the DNA Purification Protocol for the Thermo Scientific KingFisher Flex and BindIt 3.1 Software
Thermo Fisher Scientific
Purpose: Optimal quantity and quality of DNA with the magnetic particle based extraction technology. Method: Thermo Scientific KingFisher Flex magnetic particle processor and BindIt® 3.1 Software. Results: By simple optimization of the nucleic acid extraction protocol it is possible to achieve a great yield of high quality DNA.
