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Featured Products
Featured ProjectOneSeq Target Enrichment System
OneSeq Target Enrichment System
Featured ProjectQIAGEN’s Liquid Biopsy Portfolio – from Sample to Insight
QIAGEN’s Liquid Biopsy Portfolio – from Sample to Insight

Webcasts
The Tip of the Iceberg - How Pipette Tips Influence Assay ResultsThe Tip of the Iceberg - How Pipette Tips Influence Assay Results
n this webinar, you will learn everything you need to know about pipette tips and the huge impact they can have on your results.
Pipette calibration - DonPipette calibration - Don't risk your results!
In this educational webinar, you will learn why the calibration of liquid handling instruments is important, how calibration is performed in a professional service center and which instruments should be calibrated on a regular basis.

Market Reports
The Future of Molecular Diagnostics: Innovative technologies driving market opportunities in personalized medicine
Business Insights

This report analyzes the current and potential world markets for molecular diagnostics, including advances in the field. This report generally forecasts future growth to 2015. The report breaks down market forecasts by type of test and by geography. It indicates which companies have key products in the market place. It also analyzes key drivers of this market.
Scientific News
Featured Article
Big Genetics in BC: The American Society for Human Genetics 2016 Meeting
Themes at this year's meeting ranged from the verification, validation, and sharing of data, to the translation of laboratory findings into actionable clinical results.

Accelerating the Detection of Foodborne Bacterial Outbreaks
The speed of diagnosis of foodborne bacterial outbreaks could be improved by a new technique developed by researchers at the Georgia Institute of Technology.
Antibiotics Discovered While Sifting Through Human Microbiome
Researchers identify genes in a microbe’s genome that produce antibiotic compounds, then synthesize them without the need for bacterial culture.
A Genome-wide View of Human DNA Viruses
In this study, Duplex sequencing was used to accurately analyse the genome-wide rate of spontaneous mutation of human adenovirus C5 (HAdv5).
Peer Review is in Crisis, But Should be Fixed, Not Abolished
After the time to get the science done, peer review has become the slowest step in the process of sharing studies, and some scientists have had enough.
Rare Immunodeficiency Yields Unexpected Insights
Scientists uncover previously unknown gene mutation revealing the role of a key molecule involved in immune cell development.
Cancer Genetics: Key to Diagnosis, Therapy
When applied judiciously, cancer genetics directs caregivers to the right drug at the right time, while sparing patients of unnecessary or harmful treatments.
Illumina Contributes to ClinVar Database
The contribution includes variants of all classifications, from pathogenic to benign, identified during interpretation of whole genome sequences generated in the CLIA-certified, CAP-accredited Illumina Clinical Services Laboratory.
Agilent Presents Early Career Professor Award to Dr. Roeland Verhaak
JAX professor recognized for the development and implementation of workflows for the analysis of big-data from transcriptomics to next generation sequencing approaches.
Integrated Omics Analysis
Studying multi-omics promises to give a more holistic picture of the organism and its place in its ecosystem, however despite the complexities involved those within the field are optimistic.
Business News
Myeloma Genome Project Established
Celgene Corporation, Dana-Farber Cancer Institute and University of Arkansas for Medical Sciences establish the Myeloma Genome Project.
Good Start Genetics, Roche Announces Marketing Agreement
Agreement to sell Good Start’s carrier screening service for inherited genetic disorders.
Helix Selects DNA Genotek’s Oragene® Collection Device and GenoFIND Services
Oragene® collection device to provide reliable self-collection of DNA samples to be used in a genetic information discovery service offered by Helix for consumers.
Trovagene, Boreal Genomics Collaborate
Collaboration aims to co-develop urine and blood ctDNA assay kits.
Tempus, Penn’s Abramson Cancer Center Collaborate
Collaboration aims to better determine which patients will have a positive response to immunotherapy treatment based on next generation genomic and transcriptomic sequencing.
Novogene Completes USD $75 Million B Round Financing
The Series B financing will support strategic growth in Novogene’s global NGS service market and in clinical sequencing R&D and services.
Congenica, Elucigene Partner on NGS Cystic Fibrosis Kit
Accurate variant analysis facilitates personalised care pathways.
NHS to Adopt NIPT for High Risk Women
Premaitha Health welcomes the decision by the UK’s Department of Health to make non-invasive prenatal tests routinely available on the NHS to high risk* pregnant women across the UK.
NY State Approves CombiPGS™ NGS Test
The CombiPGS™ test is for women undergoing in vitro fertilization and screens embryo biopsy cells for chromosomal abnormalities prior to implantation of the embryo.
Horizon, Sophia Genetics Partner to Improve NGS Testing for Cancer
Partnership combines Horizon’s HDx™ Reference Standards with Sophia Genetics’ artificial intelligence.

Events
SLAS2017
04 Feb 2017
SLAS2017 ...
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5th Plant Genomics & Gene Edit
16 Mar 2017
5th Plant Genomics & Gene Edit ...
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Arablab 2017
20 Mar 2017
Arablab 2017 ...
More Information
qPCR, dPCR & NGS 2017
03 Apr 2017
qPCR, dPCR & NGS 2017 ...
More Information

ePosters
A Novel Cell-Free DNA Extraction System for Cancer Diagnostics
Vela Diagnostics Pte. Ltd., Singapore

We developed a magnetic bead-based cfDNA extraction kit and integrated it into the automated qPCR- and NGS-based IVD workflows. In this study we are compering this magnetic beads-based cfDNA extraction system with a column-based method.
CRISPR-Cas9 genome editing utilizing chemically synthesized RNA
GE Healthcare Dharmacon, Inc.

Chemical synthesis has been easily applied for rapidly generating either crRNA and tracrRNA or synthetic sgRNA for direct delivery into cells for gene editing applications such as DNA-free options and high throughput arrayed screening.
The Chemical Synthesis of Long and Highly Modified RNA using 2'-ACE Chemistry
GE Healthcare Dharmacon, Inc.

Dharmacon has previously developed a novel RNA synthesis chemistry making RNA synthesis as reliable, accessible and of comparable quality as routinely observed in DNA synthesis.
Experimental design considerations for efficient and specific gene knockin using a CRISPR-Cas9 for HDR with synthetic crRNA and tracrRNA
Dharmacon, part of GE Healthcare

Precise genome engineering with CRISPR-Cas9 and single-stranded DNA oligo or double-stranded DNA plasmid donors via homology-directed repair (HDR).
Integrated Next-Generation Sequencing and qPCR Workflow in Clinical Diagnostics
Vela Diagnostics Pte. Ltd., Singapore

Combined automated qPCR and NGS Sentosa workflow is a reliable and efficient in vitro diagnostics (IVD) tool for the detection and/or quantitation of a wide range of bacterial and viral pathogens as well as gene mutations.
CRISPR-Cas9 genome editing utilizing chemically synthesized RNA
Dharmacon (part of GE Healthcare)

CRISPR-Cas9 gene editing using synthetic crRNA:tracrRNA or sgRNA is highly efficient and easy to use. Synthetic crRNA:tracrRNA is uniquely suited to in vitro and in vivo applications, in particular, DNA-free approach with Cas9 mRNA. Chemical synthesis of guide RNAs allows accurate and rapid production of arrayed crRNA libraries for high-confidence, loss-of-function screens.
Customizable exon-centric target enrichment strategy for copy number and SNP analysis
Agilent Technologies

Agilent’s Custom OneSeq provides a comprehensive, flexible, and cost-effective means to identify exon-level copy number changes as well as SNP/INDEL in one assay.
Advanced Microfluidic Mixing Device for the Study of Macromolecule Dynamics
Department of Biomedical, IIT Hyderabad

We have developed and characterized a micro-fluidic mixer to study the macro-molecule dynamics such as kinetics of protein folding, DNA sequencing, single molecule study and detection etc. on a micro-second timescale. Numerical simulation has been performed to analyse the study of mixing performance of micro-fluidics channel.
DNA-free CRISPR-Cas9 genome engineering in zebrafish
Dharmacon (part of GE Healthcare)

Poster describing the advantages of a DNA-free gene editing system and the application of this system in zebrafish.
600 base reads on the Ion S5™ Next-Generation Sequencing System enables accurate HLA typing of 96 samples on one 530™ chip
Thermo Fisher Scientific, 5791 Van Allen Way, Carlsbad, CA, USA, 92008

We have demonstrated that by combining improvements in templating and sequencing biochemistry we are able to sequence templates longer than 600 bases with high accuracy on an Ion S5 530 chip.
These improvements open the S5 use space to include haplotyping applications that require longer reads. As a demonstration of that, we accurately typed 96 HLA samples on one 530 chip.
Application Notes
Automated Low-volume DNA Normalisation and NGS Library Prep for Single-cell Analysis
ttp labtech

This application note presents data from Prof. Stephen Quake’s lab, Stanford University, USA on the use of TTP Labtech’s automated low-volume liquid handlers for miniaturising DNA normalisation and library prep volumes for singlecell analysis.
Reduced-Bias Small RNA Library Preparation with Gel-Free or Low-Input Options
Bioo Scientific

Changes in microRNA (miRNA) expression have been shown to be associated with a variety of normal physiological processes, as well as diseases including cancer. Studies have already shown that miRNAs may provide useful markers for the development of disease diagnostic and prognostic assays.
Improved Library Prep Offers Higher Percentage of On-target Reads and Better Coverage for SureSelectXT2 Target Capture
Bioo Scientific

The seamless compatibility between the NEXTflex Pre- and Post- Capture library preparation kit and all reagents required for target capture using Agilent’s SureSelectXT2 bait set is demonstrated.
Directional qRNA-Seq: Combining the Power of Stranded RNA-Seq with the Quantitative Precision of Molecular Labels
Bioo Scientific

Bioo Scientific introduces a novel product for advanced RNA-Seq library preparation that features strand-specific RNA sequencing and correction of PCR amplification bias by molecular indexing: the NEXTflex™ Rapid Directional qRNA-Seq™ Kit.
Approaching Single-Cell Sequencing by Understanding NGS Library Complexity and Bias
Swift Biosciences Inc

This application note describes the sequence coverage performance andp reservation of molecular complexity of next generation sequencing (NGS) libraries generated from human and microbial genomic DNA using the Accel-NGS™ 2S DNA Library Kit for whole-genome sequencing (WGS) on the Illumina® platform.
Automated Illumina TruSeq® Nano DNA Sample Preparation
Tecan Group Ltd.

The TruSeq Nano DNA Sample Preparation Kit enables efficient investigation of samples where the amount of DNA available is limited. This low-input method generates excellent quality data from as little at 100 ng of DNA, allowing the study of samples with restricted DNA availability, for example from tumors, and helping to preserve precious sample material for use in future studies.
Double stranded DNA quantitation using Promega QuantiFluor® Dyes
Tecan Group Ltd.

Achieving selective and sensitive quantitation of double stranded DNA (dsDNA) using spectrophotometric methods can be problematic. Recognizing these difficulties, researchers have incorporated fluorescence-based quantitation techniques in their workflows to obtain the required sensitivity and target selectivity.
Automated Illumina NGS Sample Preparation: TruSeq® Stranded mRNA on the Hamilton Microlab STAR
Hamilton Robotics

Illumina’s sample preparation kits produce high quality libraries for DNA and RNA sequencing. Hamilton offers the robust Microlab STAR line of robotic liquid handling workstations for automating sample preparation. Together, the automation of the TruSeq Stranded mRNA sample preparation protocol on the STAR gives the user hours of reliable, unattended library preparation.
Molecular indexing for improved RNA-Seq analysis
Bioo Scientific

Most modern methods for nucleic acid analysis require the use of enzyme processing, such as DNA polymerase reactions, in the sample preparation or measurement steps. Although necessary, these enzymatic steps introduce errors in the form of incorrect sequence and misrepresented copy number. NEXTflex™ qRNA-Seq™ Kit from Bioo Scientific adds no additional steps to the work flow, costs no more than a conventional library preparation kit and increases the precision of downstream analysis.
An Integrated Solution to Simplify Library Preparation and Multiplexing for NimbleGen Sequence Capture
Bioo Scientific

The studies described herein demonstrate the capability of Bioo Scientific’s novel NEXTFlex™ DNA Pre-Capture Combo Library construction kits used in conjunction with the NimbleGen Sequence Capture technology to obtain high coverage comparative genomic data from a panel of human HapMap DNA samples.
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