Corporate Banner
Satellite Banner
Next Gen Sequencing
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Genome Sequencing Tracks Bacterial Outbreak

Published: Tuesday, September 11, 2012
Last Updated: Tuesday, September 11, 2012
Bookmark and Share
Last year, a deadly outbreak of antibiotic-resistant bacteria kept NIH’s Clinical Center in a state of high alert.

NIH staff used genome sequencing to track the microbes' spread, an approach that can be used to help control similar outbreaks in the future.

In June 2011, a severely ill 43-year-old woman was transferred from a hospital in New York to the NIH Clinical Center, a 243-bed research hospital on the NIH campus in Bethesda, Maryland. The medical staff knew she was infected with bacteria that were resistant to multiple antibiotics, so she was put in isolation immediately. Additional precautions were taken to keep the bacteria away from other patients.

After a month in the hospital, the woman was discharged and never came in contact with another patient. But a few weeks after she left, the same kind of infection was found in 2 other patients. Infections were discovered over the next 4 months at the rate of about 1 a week. Klebsiella pneumoniae, the bacteria responsible for the outbreak, is a growing threat in health care facilities, primarily affecting patients with compromised immune systems.

The Clinical Center staff teamed up with researchers from NIH's National Human Genome Research Institute (NHGRI) to figure out how the infection was spreading. The team sequenced the DNA of bacteria taken from each of the 18 patients. Having the complete sequences let the scientists see every detail of the bacteria's genetic code. Their report appeared in the August 22, 2012, issue of Science Translational Medicine.

The researchers found that the K. pneumoniae going around the Clinical Center originated with the patient from New York. Tiny differences revealed that the bacteria were transmitted to other patients on at least 3 separate occasions, creating 2 main groups of infected patients. The bacteria came from at least 2 different parts of the original patient's body.

As the outbreak continued, the infection-control team employed increasingly intensive strategies to stop the bacteria. They used a vapor of hydrogen peroxide to sanitize rooms and removed sink drains where K. pneumoniae had been detected. Hospital staff and equipment were dedicated to the sole care of infected patients.

The patient from New York was treated with the help of colistin, an older, toxic antibiotic considered a drug of last resort. But 11 of the patients died—6 from the infection and 5 from their underlying diseases.

The researchers say other hospitals will be able to use this approach to better understand the infections they are battling. “This study makes it clear that genome sequencing, as it becomes more affordable and rapid, will become a critical tool for healthcare epidemiology in the future,” says Dr. David Henderson, deputy director for clinical care at the NIH Clinical Center.

“Genomic data can identify unexpected modes of transmission,” says NHGRI senior investigator Dr. Julie Segre. “Though the transmission path is difficult to detect, the genomic data is indisputable.”


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,200+ scientific posters on ePosters
  • More than 4,700+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Significant Expansion Of Data Available In The Genomic Data Commons
Cancer genomic profile information from 18,000 adult cancer patients will be added to the database.
Wednesday, June 29, 2016
Using Genetic Sequencing to Manage Cancer in Children
A team of scientists have investigated the feasibility of incorporating clinical sequencing information into the care of young cancer patients.
Tuesday, September 15, 2015
Genetic Link For Rare Intestinal Cancer
Researchers recommend screening for people with family history.
Thursday, April 16, 2015
Tumor DNA in Blood Reveals Lymphoma Progression
Using an advanced genetic test, researchers were able to detect diffuse large B-cell lymphoma (DLBCL) in blood serum before it could be seen on CT scans.
Tuesday, April 14, 2015
Comprehensive Genomic Study of Sub-Saharan Africans Conducted
New data resource will enhance disease research and genomic diversity studies.
Thursday, December 04, 2014
NIH Exceptional Responders to Cancer Therapy Study Launched
Study to investigate the molecular factors of tumors associated with exceptional treatment responses of cancer patients to drug therapies.
Friday, September 26, 2014
NIH Awards $14.5M for DNA Sequencing Techniques
For the past several years, nanopore research has been an important focus of the program’s grants.
Tuesday, August 05, 2014
NIH Funds $24M into Alzheimer’s Disease Genome Research
Scientists will analyze genome sequence data to identify gene risk, protective factors.
Tuesday, July 08, 2014
Genetic Disorder Causing Strokes, Vascular Inflammation in Children Discovered
NIH researchers have identified gene variants that cause a rare syndrome of sporadic fevers, skin rashes and recurring strokes, beginning early in childhood.
Thursday, February 20, 2014
Speeding Validation of Disease Targets
NIH, industry and non-profits join forces to develop new treatments earlier, beginning with Alzheimer’s, type 2 diabetes, and autoimmune disorders.
Tuesday, February 04, 2014
NCI Launches Trial to Assess the Utility of Genetic Sequencing to Improve Patient Outcomes
Trial could identify patient sub-groups that are likely to benefit from certain treatments.
Saturday, February 01, 2014
NIH Deposits First Batch of Genomic Data for Alzheimer’s Disease
Researchers can now freely access the first batch of genome sequence data from the Alzheimer’s Disease Sequencing Project (ADSP).
Monday, December 02, 2013
NIH Awards Focus on Nanopore Technology For DNA Sequencing
The use of nanopore technology aimed at more accurate and efficient DNA sequencing is the main focus of grants awarded by the NIH.
Monday, September 09, 2013
New Genes for Childhood Epilepsies Discovered
New strategy may find more genes and provide a better understanding of these and other complex neurological disorders.
Monday, August 12, 2013
NIH, Lacks Family Reach Understanding to Share Genomic Data of HeLa Cells
New NIH policy requires researchers to apply for access to the full genome sequence data from HeLa cells.
Thursday, August 08, 2013
Scientific News
Benchtop Automation Trends
Gain a better understanding of current interest in and future deployment of benchtop automated systems.
Four Newly-Identified Genes Could Improve Rice
A Japanese research team have applied a method used in human genetic analysis to rice and rapidly discovered four new genes that are potentially significant for agriculture. These findings could influence crop breeding and help combat food shortages caused by a growing population.
What Makes a Good Scientist?
It’s the journey, not just the destination that counts as a scientist when conducting research.
Biomarkers That Could Help Give Cancer Patients Better Survival Estimates Discovered
UCLA research may also help scientists suppress dangerous genetic sequences.
Mobile Laboratories Help Track Zika Spread Across Brazil
Researchers from the University of Birmingham are working with health partners in Brazil to combat the spread of Zika virus by deploying a pair of mobile DNA sequencing laboratories on a medical ‘road trip’ through the worst-hit areas of the country.
How “Silent” Genetic Changes Drive Cancer
The researchers found that EXOSC2 expression is enhanced in metastatic tumors because their cells have increased levels of a tRNA called GluUUC.
‘Jumping Gene’ Took Peppered Moths To The Dark Side
Researchers from the University of Liverpool have identified and dated the genetic mutation that gave rise to the black form of the peppered moth, which spread rapidly during Britain’s Industrial Revolution.
How Did The Giraffe Get Its Long Neck?
Clues about the evolution of the giraffe’s long neck have now been revealed by new genome sequencing.
Big Data Can Save Lives
The sharing of genetic information from millions of cancer patients around the world could be key to revolutionising cancer prevention and care, according to a leading cancer expert from Queen's University Belfast.
Making Genetic Data Easier to Search
Scripps team streamlines biomedical research by making genetic data easier to search.
Skyscraper Banner

SELECTBIO Market Reports
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,200+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,700+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!