Corporate Banner
Satellite Banner
Next Gen Sequencing
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

New NIH/NHGRI Grants to Harness Nanoscale Technologies to Cut DNA Sequencing Costs

Published: Monday, September 17, 2012
Last Updated: Monday, September 17, 2012
Bookmark and Share
Grants of almost $19 million will help to develop technologies to dramatically reduce the cost of DNA sequencing.

During the past decade, DNA sequencing costs have fallen dramatically (see www.genome.gov/sequencingcosts), fueled by tools, technologies and process improvements developed by genomics researchers. In 2004, NHGRI launched the Advanced DNA Sequencing Technology Program to accelerate improvements in DNA sequencing technologies. By 2009, the program had surpassed its initial goal of producing high-quality genome sequences of roughly 6 billion base pairs — the amount of DNA found in humans and other mammals that receive roughly 3 billion base pairs from each of their parents — for $100,000 each. Today, the cost of sequencing a human genome using these next-generation DNA sequencing technologies has dipped to just under $8,000.

Price is one hurdle in the way of widespread use of genomics in research and clinical care. Speed and accuracy are among other factors. The grants will attempt to address all of these challenges.

"We can now access data we could not dream of getting in 2004 when we started this program — tens of thousands of human genome sequences have been generated," said Eric D. Green, M.D., Ph.D., NHGRI director. "And yet, the information we would truly like to get for understanding disease and, eventually, for treating patients, requires much better quality sequence data. That is the direction we would like to go with these grants."

The use of nanoscale devices for sequencing, reflected in many of these projects, is accelerating. To say that nanoscale devices function on a very small scale is an understatement. A human hair is 100,000 nanometers in diameter and a single strand of DNA is 2 nanometers in diameter.
"Several of the investigative teams will explore novel nanoscale sensing modes and approaches for manipulating DNA molecules with great precision by using nanoscale structures," noted Jeffery A. Schloss, program director for NHGRI’s Advanced DNA Sequencing Technology Program.

The 2012 awards are:

Genapsys, Inc., Redwood City, CA.
Hesaam Esfandyarpour, Ph.D.
Funding amount: $1.2 million in fiscal 2012 (total $3.3 million over three years subject to the availability of appropriations)
Aim: Develop easy-to-use, chip-based DNA sequencing that combines multiple sample processing steps with sequencing in a single device called the Gene Electronic Nano-Integrated Ultra-Sensitive platform.

Harvard University, Cambridge, Mass.
Jene Golovchenko, Ph.D., and Daniel Branton, Ph.D.
Funding amount: $1.2 million in fiscal 2012 (total $3.6 million over three years subject to the availability of appropriations)
Aim: Develop a scalable graphene nanopore sequencing device that will identify DNA subunits on unlabeled, single-stranded genomic DNA molecules. Graphene is a special arrangement of a single layer of carbon atoms. The nanopore is a hole in the graphene about two nanometers in diameter.

GnuBIO, Inc., Cambridge, Mass.
Tal Raz, Ph.D., with David Weitz, Ph.D., Harvard University
Funding amount: $1.5 million fiscal 2012 (total $4.5 million over three years subject to the availability of appropriations)
Aim: Increase the throughput of the current single channel microfluidic instrument to enable whole genome sequencing in about six hours, including data analysis, genome alignment and variant calling. Microfluidics refers to plastic devices in which fluids move through tiny channels that are the diameter of a human hair.

Columbia University, New York City
Kenneth Shepard, Ph.D., with Marija Drndic, Ph.D., University of Pennsylvania, Philadelphia
Funding amount: $500,000 in FY2012 (total $1.5 million over three years subject to the availability of appropriations)
Aim: Develop much faster and more sensitive electronics to enable sequencing based on arrays of nanopores.

Intel Corp., Santa Clara, Calif., University of Twente, Enschede-Noord, Netherlands, Columbia University, Pacific Biosciences, Menlo Park, CA
Madoo Varma, Ph.D., Oguz H. Elibol, Ph.D., Xing Su, Ph.D., Serge Guy Lemay, Ph.D., Kenneth Shepard, Ph.D., Stephen Turner, Ph.D.
Funding amount: $1.2 million fiscal 2012 (total $5 million over four years subject to the availability of appropriations)
Aim: Develop a real-time, single-molecule sequencer that detects electrically active tags that will be attached to each of the four DNA subunits

Northeastern University, Boston, Pacific Biosciences
Meni Wanunu, Ph.D., and Jonas Korlach, Ph.D.
Funding amount: $300,000 fiscal 2012 (total $825,000 over 3 years subject to the availability of appropriations)
Aim: Reduce the cost of Pacific Biosciences' single-molecule real-time (SMRT) DNA sequencing by reducing the amount of DNA needed to picogram levels. A picogram is 1 trillionth of a gram.


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,500+ scientific posters on ePosters
  • More than 5,000+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

New Inflammatory Disease Discovered
NIH researchers have discovered a rare and potentially deadly disease - otulipenia - the mostly affects children.
Tuesday, August 23, 2016
Significant Expansion Of Data Available In The Genomic Data Commons
Cancer genomic profile information from 18,000 adult cancer patients will be added to the database.
Wednesday, June 29, 2016
Using Genetic Sequencing to Manage Cancer in Children
A team of scientists have investigated the feasibility of incorporating clinical sequencing information into the care of young cancer patients.
Tuesday, September 15, 2015
Genetic Link For Rare Intestinal Cancer
Researchers recommend screening for people with family history.
Thursday, April 16, 2015
Tumor DNA in Blood Reveals Lymphoma Progression
Using an advanced genetic test, researchers were able to detect diffuse large B-cell lymphoma (DLBCL) in blood serum before it could be seen on CT scans.
Tuesday, April 14, 2015
Comprehensive Genomic Study of Sub-Saharan Africans Conducted
New data resource will enhance disease research and genomic diversity studies.
Thursday, December 04, 2014
NIH Exceptional Responders to Cancer Therapy Study Launched
Study to investigate the molecular factors of tumors associated with exceptional treatment responses of cancer patients to drug therapies.
Friday, September 26, 2014
NIH Awards $14.5M for DNA Sequencing Techniques
For the past several years, nanopore research has been an important focus of the program’s grants.
Tuesday, August 05, 2014
NIH Funds $24M into Alzheimer’s Disease Genome Research
Scientists will analyze genome sequence data to identify gene risk, protective factors.
Tuesday, July 08, 2014
Genetic Disorder Causing Strokes, Vascular Inflammation in Children Discovered
NIH researchers have identified gene variants that cause a rare syndrome of sporadic fevers, skin rashes and recurring strokes, beginning early in childhood.
Thursday, February 20, 2014
Speeding Validation of Disease Targets
NIH, industry and non-profits join forces to develop new treatments earlier, beginning with Alzheimer’s, type 2 diabetes, and autoimmune disorders.
Tuesday, February 04, 2014
NCI Launches Trial to Assess the Utility of Genetic Sequencing to Improve Patient Outcomes
Trial could identify patient sub-groups that are likely to benefit from certain treatments.
Saturday, February 01, 2014
NIH Deposits First Batch of Genomic Data for Alzheimer’s Disease
Researchers can now freely access the first batch of genome sequence data from the Alzheimer’s Disease Sequencing Project (ADSP).
Monday, December 02, 2013
NIH Awards Focus on Nanopore Technology For DNA Sequencing
The use of nanopore technology aimed at more accurate and efficient DNA sequencing is the main focus of grants awarded by the NIH.
Monday, September 09, 2013
New Genes for Childhood Epilepsies Discovered
New strategy may find more genes and provide a better understanding of these and other complex neurological disorders.
Monday, August 12, 2013
Scientific News
NASA's DNA Sequencing in Space is a Success
DNA has been sequenced in space for the first time ever for the Biomolecule Sequencer investigation, using the MinION sequencing device.
New Inflammatory Disease Discovered
NIH researchers have discovered a rare and potentially deadly disease - otulipenia - the mostly affects children.
Bringing NGS to the Crime Lab
New technology being validated in BCI lab for use in Ohio missing persons cases.
Expanding Knowledge of Viral Diversity
Environmental datasets help researchers double the number of microbial phyla known to be infected by viruses.
How Cloud Connectivity Can Combat the Reproducibility Crisis
This infographic explains the reproducibility crisis, and how cloud connectivity can help overcome this problem.
The Power of Model Systems
New insights into the influence of host on the gut microbiome are revealed with in situ light sheet fluorescence microscopy and stochastic mathematical modelling.
New Way To Measure Important Chemical Modification On RNA
Technology could advance stem cells’ use in regenerative medicine, UCLA researchers say.
Mapping Antibody Creation in Humans
Researchers have created the first, detailed map of the body's antibody production, which could suggest new treatment options for immune disorders.
Decoding the Genome of the Olive Tree
A team of scientists from three Spanish centers has sequenced, for the first time ever, the complete genome of the olive tree. This work will facilitate genetic improvement for production of olives and olive oil, two key products in the Spanish economy and diet.
Four Newly-Identified Genes Could Improve Rice
A Japanese research team have applied a method used in human genetic analysis to rice and rapidly discovered four new genes that are potentially significant for agriculture. These findings could influence crop breeding and help combat food shortages caused by a growing population.
Skyscraper Banner

SELECTBIO Market Reports
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,500+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
5,000+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!