Corporate Banner
Satellite Banner
Next Gen Sequencing
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

National Study to Examine Risks, Benefits in Emergent Whole Genome Sequencing

Published: Tuesday, March 19, 2013
Last Updated: Tuesday, March 19, 2013
Bookmark and Share
UCSF School of Pharmacy faculty member to lead four-year, $2.4 million project.

Improving technologies are rapidly cutting the cost of whole genome sequencing, a process that reveals the complete library of a patient’s genetic information. Indeed, the era of the $1,000 genome — a catchphrase for the test’s relative affordability — appears imminent.

But will the wider application of this encyclopedic option in personalized medicine help patients and health care providers prevent and more effectively treat diseases, or will it open a Pandora’s Box of confusion, fears, and costly, unnecessary treatments?

UCSF School of Pharmacy faculty member Kathryn Phillips, PhD, will lead the first national study to analyze how physicians and patients in the general population, as well as those given whole genome sequencing results in a clinical trial, evaluate the benefits and risks posed by this profusion of genetic information. The project will address questions such as:

•    How much do patients want to know?
•    How do patients and physicians assess the significance and usefulness of these tests’ myriad potential findings?
•    Which findings call for medical intervention versus monitoring?
•    What about likely future conditions that currently cannot be treated?

The four-year, $2.4 million project, “Benefit-Risk Tradeoffs for Whole Genome Sequencing,” recently funded by the National Human Genome Research Institute (NHGRI), will also be the first to systematically examine the overall implications of such testing for the health care system and for society by considering, for example:

•    When should complete genome sequencing be recommended by health care providers and covered by insurers as clinically useful?
•    Will the economic value of preventing disease or more effectively targeting treatments outweigh the costs of the initial whole genome sequencing testing, plus additional testing and treatments its results may generate?
•    How can whole genome sequencing findings be most appropriately and effectively applied?


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,000+ scientific posters on ePosters
  • More than 4,500+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Industry-Sponsored Academic Inventions Spur Increased Innovation
Analysis questions assumption that corporate support skews science toward inventions that are less useful than those funded by the government or non-profit organizations.
Monday, March 24, 2014
International Fruit Pest Targeted by Genomic Research
The spotted wing drosophila is itself being targeted, thanks to groundbreaking genome sequencing.
Friday, December 06, 2013
Scientists Pinpoint Cell Type and Brain Region Affected by Gene Mutations in Autism
UCSF-led study zeroes in on when and where disrupted genes exert effects.
Tuesday, November 26, 2013
DNA Found Outside Genes Plays Largely Unknown, Potentially Vital Roles
UCSF study identifies thousands of previously unknown RNA molecules.
Monday, July 01, 2013
Genetic Study Shows Europeans are One Big Family
Europeans are basically one big family, closely related to one another for the past thousand years, according to a new study of the DNA of people from across the continent.
Wednesday, May 08, 2013
Tick-Borne Lone Star Virus Identified through New Super-Fast Gene Sequencing
The tick-borne Lone Star virus has been conclusively identified as part of a family of other tick-borne viruses called bunyaviruses, which often cause fever, respiratory problems and bleeding.
Tuesday, May 07, 2013
New Center for Data Storage Research Established
Researchers in the Baskin School of Engineering at UC Santa Cruz are partnering with data storage industry to establish the Center for Research in Storage Systems (CRSS).
Thursday, March 28, 2013
New Network Being Built to Support Transfer of Big Data
The University of California, San Diego, is taking another leap forward in the name of enabling data-intensive science.
Thursday, March 21, 2013
'Defective' Virus Plays Major Role in Spread of Disease
Defective viruses now appear able to play an important role in the spread of disease, new research by UCLA life scientists indicates.
Friday, March 01, 2013
Methylome Modifications Offer New Measure of our “Biological” Age
Women live longer than men. Individuals can appear or feel years younger – or older – than their chronological age. Diseases can affect our aging process. When it comes to biology, our clocks clearly tick differently.
Monday, November 26, 2012
Gladstone Scientists Map Genomic Blueprint of the Heart
Findings could help scientists combat the underlying causes of congenital heart disease.
Friday, September 14, 2012
Beyond Base-pairs: Mapping the Functional Genome
Unprecedented study maps significant portion of the functional sequences of the mouse genome.
Wednesday, July 04, 2012
Gene Mutations Likely Cause of Massive Brain Asymmetry
It is hoped that these genetic changes can be inhibited by designer drugs, thus avoiding drastic surgery.
Tuesday, June 26, 2012
Scientific News
Monovar Drills Down Into Cancer Genome
Rice, MD Anderson develop program to ID mutations in single cancer cells.
Five New Breast Cancer Genes Found
Discovery of mutations paves the way for personalised treatment of breast cancer.
New Neurodevelopmental Syndrome Identified
Study pinpoints underlying genetic mutations, raising hopes for targeted therapies.
Uncovering Hidden Genomic Alterations that Drive Cancers
Tested on large tumor genomics database, REVEALER method allows researchers to connect genomics to cell function.
Gene Behind Rare Childhood Syndrome Identified
Online activism by one patient’s mother spurred research collaboration which led to the identification of a new genetic syndrome.
Resilience Project Identifies Rare Unaffected Individuals
Researchers from Mount Sinai and Sage Bionetworks report analysis of nearly 600,000 genomes for resilience project.
Rare DNA Will Have Nowhere To Hide
Two National Institutes of Health grants back Rice University effort to develop new diagnostics.
Virus Causing Tilapia Die-Offs Identified
Discovery of the virus causing Tilapia die-offs in Israel and Ecuador points the way to protecting a fish that feeds multitudes.
Children With Cancer To Get New Gene Test
Pilot study will sequence 81 cancer genes in children’s tumours to help personalise cancer treatment.
How The Bat Got Its Wings
Finding may provide clues to human limb development and malformations.
Skyscraper Banner

SELECTBIO Market Reports
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,000+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,500+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!