Corporate Banner
Satellite Banner
Next Gen Sequencing
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

AD GWAS in African Americans Confirms, Reshuffles AlzGene List

Published: Monday, April 15, 2013
Last Updated: Monday, April 15, 2013
Bookmark and Share
African Americans carrying a variant in a cholesterol-processing gene have double the risk for Alzheimer’s than non-carriers.

This gene, for a membrane transporter protein called ABCA7, is the greatest difference between African American and Caucasian Alzheimer’s risk to emerge from the largest genomewide association study (GWAS) for AD performed in African Americans to date. The study appears April 10 in the Journal of the American Medical Association. In African Americans, ABCA7 variation is the strongest genetic risk factor for AD outside of the ApoE4 allele. Other than that, the genes involved in African American AD risk paralleled those in whites, reported the study authors representing the Alzheimer's Disease Genetics Consortium.

Led by senior author Richard Mayeux at Columbia University in New York City, the researchers examined single-nucleotide polymorphisms from nearly 2,000 people with late-onset Alzheimer’s, and almost 4,000 control participants. The group collected all the data it could get from African Americans seen at more than 20 study centers, said first author Christiane Reitz, also at Columbia.

While many of the previously reported GWAS data come from people of European and European American ancestry, Reitz noted that it is important to investigate whether those genetic findings extend to people beyond that white slice of humanity. A GWAS in Hispanics is ongoing.

Several of the genes the current study picked out in African Americans matched those found in GWAS with white people. ApoE4 was the strongest risk factor; a single copy more than doubled risk of Alzheimer’s with an odds ratio of 2.31 in this report. “Replicating an association for the same alleles in different ethnic groups strengthens the case for these variants being important in increasing disease susceptibility,” commented Robert Nussbaum of the University of California, San Francisco, in an editorial accompanying the publication.

After ApoE, ABCA7 was second on the hit list. ABCA7 variants had been reported to increase risk in white people, but ABCA7 was in the middle of the pack among genes linked to AD, most of which boost risk by an average of 10-20 percent, Reitz said (Hollingworth et al., 2011). ABCA7 currently ranks fourth on the AlzGene Top 10. In the new study’s African American population, an ABCA7 variant increased one’s chances of AD by almost double, with an odds ratio of 1.79.

This kind of race-based difference is not uncommon, Reitz noted. She suspects that the ABCA7 polymorphisms found in Caucasians point to specific functional mutations different from those carried by African Americans, but the researchers have not yet sequenced the gene to check. It is also possible that the genetic background of each race, as well as environmental factors, conspire with ABCA7 variants to produce a higher risk in African American carriers than in whites.


Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,500+ scientific posters on ePosters
  • More than 3,700+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.


Scientific News
Liquid Biopsies: Utilization of Circulating Biomarkers for Minimally Invasive Diagnostics Development
Market Trends in Biofluid-based Liquid Biopsies: Deploying Circulating Biomarkers in the Clinic. Enal Razvi, Ph.D., Managing Director, Select Biosciences, Inc.
Rescuing Genetic Material from Formaldehyde Treated Tissue Samples
Formaldehyde is excellent for preserving cellular structures, but it makes it difficult to pull genetic information from tissue samples. Eric Kool and colleagues have developed a catalyst that saves RNA, which could lead to better patient outcomes.
DNA Damage Seen in Patients Undergoing CT Scanning
Along with the burgeoning use of advanced medical imaging tests over the past decade have come rising public health concerns about possible links between low-dose radiation and cancer.
Web App Helps Researchers Explore Cancer Genetics
Brown University computer scientists have developed a new interactive tool to help researchers and clinicians explore the genetic underpinnings of cancer.
New Research Advances Genetic Studies in Wildlife Conservation
‘Next-gen’ DNA sequencing of non-invasively collected hair expands field of conservation genetics.
Gene Testing Now Allows Precision Medicine for Thoracic Aneurysms
Researchers at the Aortic Institute at Yale have tested the genomes of more than 100 patients with thoracic aortic aneurysms, a potentially lethal condition, and provided genetically personalized care.
OGT’s Popular ESHG Workshop Free to View Online
Learn about the next generation of microarrays in one of the best attended workshops of the conference.
Discordant NIPT Test Results May Reflect Presence of Maternal Cancer
Results published in Journal of the American Medical Association.
Sperm RNA Test May Improve Evaluation of Male Infertility
To help resolve uncertainty—and guide prospective parents to the right fertility treatments—scientists propose the use of a new kind of fertility test. It involves examining sperm RNA by means of next-generation sequencing.
How the Mammoth Got its Wool
Evolutionary change in a gene reconstructed in the lab from the woolly mammoth was part of a suite of adaptations that allowed the mammoth to survive in harsh arctic environments, according to new research.
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,500+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
3,700+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FREE!