BioSante Pharmaceuticals Reports Positive LibiGel Safety Data Review for Phase III Program
BioSante Pharmaceuticals Reports Positive LibiGel Safety Data Review for Phase III Program.

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Anacor Pharmaceuticals Announces Preliminary Results from Two Safety Studies
AN2728 studies provide positive results, ointment well tolerated on large body surfaces and sensitive skin.

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NanoInk Announces Launch of Contract Services Program for Live Single Cell Assay Work
Service offering expected to advance research programs involved with toxicity assessment, high content screening, and cell-cell communication.

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Neonatal Respiratory Distress Syndrome Treatment Comparison Shows Lower Mortality Rates
New analysis published in eFirst pages of Pediatrics website also shows reduced need for redosing when using CUROSURF Intratracheal Suspension.

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Dundee Researchers Seek to Beat "Molecular Obesity"
Researchers from the University of Dundee have come up with a new innovative approach in the quest to reduce failure rates in the drug discovery process.

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Deutsch Foundation-Sponsored Work Offers Multi-Pronged Attack on Major Medical Problem
Researchers create a microfluidic “lab on a chip” that uses light to monitor biofilm formation and biofilm response to drugs, detects growth and thickening of biofilms by monitoring translucency.

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Leading Romanian Research Institution Expands Capabilities With Purchase of a NanoInk DPN 5000 System
The DPN 5000 System will be used for supramolecular structure fabrication, molecular recognition and self-assembling process applications.

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Infrared Spectroscopy and Microscopy in Cancer Research and Diagnosis
This review illustrates some principles of Fourier transform Infrared vibrational spectroscopy and microscopy as a useful method to interrogate molecules in specimen by mid-IR radiation.

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Kadmon Acquires First-in-Class Ras Antagonist from Concordia Pharmaceuticals
The companies announced the signing of an asset purchase agreement under which Kadmon has acquired all rights to salirasib, a Phase 2, novel, orally available, small molecule therapeutic in development for the treatment of solid tumors.

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Ikaria INOmax DS Drug Delivery System: FDA Impose Class I Recall - Erratic Nitric Oxide (NO) Readings
The erratic readings were being caused by fretting corrosion at the electrical contact interface of certain metals. Adverse consequences may include inadequate oxygen reaching the tissues in the body (hypoxia), low blood pressure (hypotension), slower than normal heart rate (bradycardia), cardiac arrest, organ damage, acute respiratory distress syndrome (ARDS), neurological deficits, or death.

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Sol-Gel Signs $27 M Deal for Dermatology Drug Delivery
Company has entered into a second development and licensing agreement with a leading U.S. pharmaceutical company.

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Malvern Instruments and Postnova Analytics Co-operate
Both companies co-operate to deliver combined solution for characterizing challenging particulate systems.

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Critical Pharmaceuticals and The University of Nottingham to Develop Nano-Enabled Nasal Spray for Osteoporosis
The Technology Strategy Board and the Engineering and Physical Sciences Research Council (EPSRC) provide grant funding to support the £545,000 project.

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Spain Nanotechnology in Nano Tech 2012 Exhibition (Tokyo, Japan)
Spanish Nanoscience and Nanotechnology (N&N) companies, science and technology research centers and industry associations are present for the fifth time after receiving 2011 ‘Special Award’.

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Nanoink Announces Launch of Contract Services Program for Live Single Cell Assay Work
Service offering expected to advance research programs involved with toxicity assessment, high content screening, and cell-cell communication.

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Marina Biotech Announces Closing of $1.5 MM Bridge Loan
The company announced the closing of a bridge loan pursuant to a Note and Warrant Purchase Agreement.

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Bruker Hosts 10th Annual International Nanoscience
Call for papers for "Seeing at the Nanoscale 2012".

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Xagenic Inc. Closes $10 Million Series A Financing
Funding will support development of on-demand molecular diagnostic system and lead tests; changes to Board of Directors announced.

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InspireMD Appoints Dr. James Barry to Its Board of Directors
Dr. Barry is an experienced medical technology executive and former senior executive at Boston Scientific with a proven track record of bringing products to market.

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JPK Reports on the Current Research Activities at Karlsruhe Institute of Technology
Dr Clemens Franz leads a group of researchers at the DFG-Center for Functional Nanostructures at Karlsruhe Institute of Technology where he works on expanding the use of AFM for cell biological applications.

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Antibacterial Activity of Silver Nanoparticles Obtained by Electrochemical Synthesis in Poly(Amide-Hydroxyurethane) Media
Alexandru Ioan Cuza University of Iasi, Romania

Due to the outbreak of the infectious diseases caused by pathogenic bacteria, inorganic nanoparticles (NPs) have emerged up as novel antimicrobial agents.

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Evaluation of bactericidal efficacy of sulfur nanoparticles (SNPs) against multidrug resistant isolates of Escherichia coli and Klebsiella pneumoniae
Indian statistical Institute

Bactericidal efficacy of engineered sulfur nanoparticles

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Molecular dynamics of POPC and POPE lipid membrane bilayers enforced by an intercalated single-wall carbon nanotube
Würzburg University

In this study, we used high temperature molecular dynamics simulation (400 K), because it is known that critical fluctuations of lipid membranes can even occur at 313 K and especially above 343 K the interlamellar water layer thickness starts to increase non-linearly due to "hydration force". We implemented this method to emphasize POPC and POPE (palmitoyl-oleoyl-phosphatidylethanolamine) membrane bilayer stability enhanced with single-wall carbon nanotube.

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Microfluidic chips with nanostructures for investigation of biological objects by methods of high resolution microscopy
1 National Research University of Information Technologies, Mechanics and Optics, Kronverkskiy pr., 49, Saint-Petersburg, 197101, Russian Federation;

We have designed and fabricated a microfluidic chips (MFC) with integrated net of nanochannels (traps) for fixation of biological samples in their native environment during study by SPM and CLSM. These traps were created by method of focused ion beam lithography. The width of fabricated nanochannels is in the range from 50 to 300 nm. Fabricated MFC were investigated on test samples in liquid buffer solution.

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Controlled Synthesis and Manipulation of Self-Assembled Peptide Nano Spheres by Microfluidic Dielectrophoresis (DEP)
DTU Nanotech

The self-assembled peptides as building blocks are excellent candidates for applications in biomedical nanotechnology because of their chemical diversity, flexibility, biocompatibility and stability. This work shows a stable synthesis in liquid and that is's posible to manipulate them using positive DEP.

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Designing the photon electron converter in modified PEEM by Monte Carlo method
Singapore Synchrotron Light Source, National University of Singapore (NUS))

This work shows how we can design a photocathode (photon electron converter) by using Monte Carlo simulation method

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A Practical Microfluidic Device for Synthesis of Purified Monodisperse Micro-Alginate Beads (MABs) as Microcarriers of Gold Nanoparticles.
Institute of Industrial Science, The University of Tokyo

We developed a microfluidic device for encapsulating gold nanoparticles in Micro-Alginate Beads (MABs). The size and the gap of the monodisperse alginate droplets were successfully controlled by adjusting the relative "oil/sample" flow rate ratio. Droplets reacted with calcium ion at the interface between oil phase and aqueous phase so that MABs precipitated spontaneously and undergone complete gelation. Purified MABs were successfully observed by fluorescence microscopy.

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Hyaluronan-Chitosan Polyelectrolytic Complex as a Platform for Delivery of Cytotoxic Agents
University of Minnesota Duluth. Dept Chemical Engineering

Described here is a biomimetic hydrogel adapted to serve as a high concentration, regional delivery system for cytotoxic agents. Paclitaxel was conjugated with low molecular weight hyaluronan to render it water soluble, then embedded in the HCP-h hydrogel for delivey to a culture of C8161 malignant melanoma cells. Live/dead staining of cells was used to monitor effectiveness of paclitaxel release from its HCP-h depot.

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Clinical Evaluation of human embryonic stem cells (hESCs) induced with directed differentiation to gonadotrope cells to cure vasculogenic impotency and to improve coital frequency in males. An open st
University Hospital Malmo Sweden, Stanford Biomed, Inc. Stanford, California, USA, Syed Skin Care, Inc. San Francisco, California, USA

This work demonstrates the clinical efficacy, tolerability and safety of patient-syngenic hESC induced with directed differentiation to gonadotrope cells. Hypothalamus transmits gonadotropin releasing factor to pituitary that sets off LH and FSH to Sertoli cell and Seminiferous tubule resulting Leydig cell to produces testosterone. This potential offers a rationale to evaluate hESCs to cure patients with vasculogenic impotency and to improve coital frequency in males.

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Clinical Evaluation of induced pluripotent stem cells (iPSc) to cure patients with Psoriasis Vulgaris. An Open Study.
University Hospital Malmo, Sweden, Stanford Biomed Inc. Syed Skin Care, Inc.

To evaluate the clinical efficacy of iPSc directed to interfere T-cell activation to cure patients with psoriasis. Twenty subjects were enrolled. Each patient was administered iv with syngenic iPS. Those showing lower PASI score were considered cured. The study states that induced iPSCs are safe and impart significant clinical efficacy to cure patients with psoriasis.

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Structure Property Correlation of Bio-nanocomposites
Anasys Instruments Corp

Dimensional similarities between physical characteristics of polymers (such as radius of gyration and lamellar thickness) and nano-sized reinforcing particles lead to the necessity to go beyond filled systems [1] and explore in detail polymer-particle interactions responsible for the improved properties of polymer nanocomposites. Dispersion is a key issue in processing polymer nanocomposites, and has a strong impact on mechanical properties. As opposed to phase separation (more likely to occur w

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Raman Spectroscopy and nano-TA analysis of a Polymer Blend
Anasys Instruments Corp

Characterizing polymer blends can sometimes present a significant challenge for a single technique and the best way is a combination of techniques. In this application note, we discuss an PA6-PET blend which was initially characterized via Raman Spectroscopy at a 500nm spatial resolution. Subsequent thermal characterization at a sub-100nm spatial resolution via the nano-TA revealed a lot of interesting details and more complex sub-structures that were not available from the Raman study and helpe

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Failure Analysis - Identification of Particles in a Polymer Film
Anasys Instruments Corp

Nano-TA is a local thermal analysis technique which combines the high spatial resolution imaging capabilities of atomic force microscopy with the ability to obtain understanding of the thermal behaviour of materials with a spatial resolution of sub-100nm. This breakthrough in spatial resolution of thermal analysis, which is ~50X better than the state of the art, has profound implications for the fields of Polymers and Pharmaceuticals where local thermal understanding is key.

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Heated tip-AFM of nanocomposite Polymer Membranes
Anasys Instruments Corp

Nanocomposite Polymer Membranes: Unlike traditional composite materials whose properties are influenced largely by the constituent components, nanocomposites exhibit such large specific surface areas that interfacial properties can significantly affect bulk behaviour. Poly trimethyl silyl propyne (PTMSP) has garnered attention since its discovery due to its very high permeability, high Tg and exhibited reverse selectivity[1, 2]. However, it was the discovery that the permeability and reverse sel

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Heated Tip-AFM of Energetic Materials: Nano-dectonics
Anasys Instruments Corp

Energetic Materials are materials that exhibit dramatic release of stored chemical energy as thermal and mechanical energies. The primary difference between an energetic material and any material that undergoes a chemical decomposition process is the rate at which the decomposition occurs. The decomposition rate is determined by a number of factors including the particle characteristics (chemical composition, size, morphology), the magnitude and duration of the reaction stimulus, and material co

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Correlation between nanoscale and bulk Thermal Analysis
Anasys Instruments Corp

Thermal methods such as differential scanning calorimetry (DSC) and modulated temperature DSC (MDSC), thermogravimetric analysis (TGA), thermomechanical analysis (TMA), and dynamic mechanical analysis (DMA) are well-established techniques for characterizing the morphology and composition of polymers. It is often possible to identify and quantify materials by reference to their characteristic transition temperatures and thermal stability. However, a serious limitation of conventional thermal meth

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Analyzing Nanoscale inclusions within a Polymer Matrix
Anasys Instruments Corp

Nano-TA is a local thermal analysis technique which combines the high spatial resolution imaging capabilities of atomic force microscopy with the ability to obtain an understanding of the thermal behaviour of materials with a spatial resolution of sub-100nm. This breakthrough in spatial resolution of thermal analysis, which is ~50x better than the state of the art, has profound implications for the fields of polymers and pharmaceuticals where understanding local thermal properties is key.

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Nano-Structure Properties of a Drug Release Coating
Anasys Instruments Corp

HPMC-EC: Blends of hydroxypropyl methylcellulose (HPMC) and ethyl cellulose (EC) are widely used as coatings for solid dosage forms to control drug release rates. This study aimed to map and determine the morphological properties of a phase-separated HPMC/EC blend at the nanometer scale using a new nanothermal analysis (nano-TA) technique, thus providing further understanding of the nature of the intermolecular interactions between the components in the blend.

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Nanobubbles – a New Class of Structure Ready for Exploitation?
NanoSight Ltd

Despite initial scepticism, acceptance of the existence and special properties of nanobubbles is now growing and their formation and characteristics are now becoming the subject of an increasing amount of study, especially in Japan.

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Direct Visualisation, Sizing & Counting of Viruses and Phages in Liquid Suspension
NanoSight Ltd

A new laser-based nanoparticle tracking analysis system is now available which allows nanoscale particles such as viruses and virus aggregates to be directly and individually visualised in liquids in real-time, from which high-resolution particle size distribution profiles can be obtained. The technique is fast, robust, accurate and low cost representing an attractive alternative or complement to existing methods of nanoparticle analysis such as Dynamic Light Scattering (DLS), Photon Correlation

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