Nanoparticles Cut Off ‘Addicted’ Tumors from Source of their Survival
Yale biologists and engineers have designed drug-loaded nanoparticles that target the soft underbelly of many types of cancer — a tiny gene product that tumors depend upon to replicate and survive.

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Good News for Nanomedicine
Quantum dots appear safe in pioneering study on primates.

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Pharmacokinetics, Metabolism and Toxicity of Carbon Nanotubes for Biomedical Purposes
This study reviews the updated data of CNTs from the biomedical view with focus on the pharmacokinetics, metabolism and toxicity of CNTs in vivo.

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Lipid-based Passivation in Nanofluidics
This study demonstrates the use of lipid bilayers as a passivation layer in nanofluidic networks, consisting of nanochannels and nanoslits, fabricated in fused silica.

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Purdue University Researchers Use Nanoscale IR Spectroscopy via AFM-IR
Utilizing this technique has provided key insights into drug-polymer blends.

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Assessing Safety of Nanomaterials
Scientists at the University of California, Los Angeles, have developed novel screening process to identify potential hazards caused by everyday nanomaterials.

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Comparing Apples and Oranges
New sensor can accurately measure fruits’ ripeness, helping prevent loss of produce from spoilage.

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Duke University Uses NTA to Characterize "Nanoconstructs" for Biomedical Applications
NTA to characterize metal nanoparticle construct materials for use in biosensing, imaging and cancer therapy.

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Real-Time Visualization and Quantitation of Vascular Permeability In Vivo: Implications for Drug Delivery
This paper presents an integrated method to visualize and quantify the real-time dynamics of dextrans in a shell-less chick chorioallantoic (CAM) model.

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'Wonder Material' Graphene May Hold Key to Fast, Inexpensive Genetic Sequencing
This article from the University of Delaware explains how graphene (graphite to the thickness of one atom) can be used to conduct high-performance DNA sequencing, based on the material’s ability to be manipulated.

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FEI Launches ‘Living Lab’ for Structural Biology Research at NIH
Official launch of Living Lab scientific program takes place May 23 on the NIH campus.

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The University of Nottingham and Promethean Particles take Lead on €10 Million Nano-Research Project
Promethean aims to increase its manufacturing capability to produce nano-materials in the SHYMAN project.

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Malvern Team Presents Poster at ACS Colloids 2012 Symposium
Dr Ana Morfesis and Dr Ulf Nobbmann will present a poster on ‘Nanoparticle characterization by light scattering’.

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Nanophase Reports First Quarter 2012 Financial Results
The company’s financial conference call is scheduled for May 18, 2012 at 11:00 a.m. EDT.

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NanoInk Expands Presence in Japan with Prestigious New Distributor
RIBM to market NanoInk’s NLP 2000 system and DPN 5000 system.

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European Life Science Awards Nominees Announced
The awards ceremony celebrates the very best of the industry’s achievements and precedes the Second European Lab Automation (ELA) conference and exhibition taking place from 30th- 31st May at the Congress Centre Hamburg.

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Prosonix to Present at RDD 2012 and ATS 2012 International Conference
Prosonix will present a poster entitled ‘Engineered Combination Respiratory Medicines for Localized Drug Delivery’ at RDD.

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NanoSight to Receive Queen's Award for Enterprise
Company announced it has been selected to receive the Queen's Award for Enterprise in the category for International Trade 2012.

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The EU Definition of Nanomaterials – Getting what you wished for?
NanoSight’s Jeremy Warren, CEO, offers the latest news and views on the EU definition on nanomaterials.

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Amgen to Acquire Mustafa Nevzat, a Privately Held Turkish Pharmaceutical Company
Acquisition will build on Amgen's business and provide a platform for growth in Turkey and this strategically important region.

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Synthesis and Characterisation of Platinum Nanoparticles Supported Vulcan Carbon Based Conductive Bipolymeric Nanoparticles
SCSVMV University

The physical interactions of Platinum nanoparticles anchored on Vulcan® carbon XC – 72 (VC) over Nafion® - Polyethylene glycol - 6000 (PEG) polymer matrix nanocomposite were characterized by Fourier Transform – Infrared (FT-IR) spectra technique and surface morphology by Scanning Electron Microscope (SEM) analyses.

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Antibacterial Activity of Silver Nanoparticles Obtained by Electrochemical Synthesis in Poly(Amide-Hydroxyurethane) Media
Alexandru Ioan Cuza University of Iasi, Romania

Due to the outbreak of the infectious diseases caused by pathogenic bacteria, inorganic nanoparticles (NPs) have emerged up as novel antimicrobial agents.

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Evaluation of bactericidal efficacy of sulfur nanoparticles (SNPs) against multidrug resistant isolates of Escherichia coli and Klebsiella pneumoniae
Indian statistical Institute

Bactericidal efficacy of engineered sulfur nanoparticles

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Molecular dynamics of POPC and POPE lipid membrane bilayers enforced by an intercalated single-wall carbon nanotube
Würzburg University

In this study, we used high temperature molecular dynamics simulation (400 K), because it is known that critical fluctuations of lipid membranes can even occur at 313 K and especially above 343 K the interlamellar water layer thickness starts to increase non-linearly due to "hydration force". We implemented this method to emphasize POPC and POPE (palmitoyl-oleoyl-phosphatidylethanolamine) membrane bilayer stability enhanced with single-wall carbon nanotube.

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Microfluidic chips with nanostructures for investigation of biological objects by methods of high resolution microscopy
1 National Research University of Information Technologies, Mechanics and Optics, Kronverkskiy pr., 49, Saint-Petersburg, 197101, Russian Federation;

We have designed and fabricated a microfluidic chips (MFC) with integrated net of nanochannels (traps) for fixation of biological samples in their native environment during study by SPM and CLSM. These traps were created by method of focused ion beam lithography. The width of fabricated nanochannels is in the range from 50 to 300 nm. Fabricated MFC were investigated on test samples in liquid buffer solution.

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Controlled Synthesis and Manipulation of Self-Assembled Peptide Nano Spheres by Microfluidic Dielectrophoresis (DEP)
DTU Nanotech

The self-assembled peptides as building blocks are excellent candidates for applications in biomedical nanotechnology because of their chemical diversity, flexibility, biocompatibility and stability. This work shows a stable synthesis in liquid and that is's posible to manipulate them using positive DEP.

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Designing the photon electron converter in modified PEEM by Monte Carlo method
Singapore Synchrotron Light Source, National University of Singapore (NUS))

This work shows how we can design a photocathode (photon electron converter) by using Monte Carlo simulation method

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A Practical Microfluidic Device for Synthesis of Purified Monodisperse Micro-Alginate Beads (MABs) as Microcarriers of Gold Nanoparticles.
Institute of Industrial Science, The University of Tokyo

We developed a microfluidic device for encapsulating gold nanoparticles in Micro-Alginate Beads (MABs). The size and the gap of the monodisperse alginate droplets were successfully controlled by adjusting the relative "oil/sample" flow rate ratio. Droplets reacted with calcium ion at the interface between oil phase and aqueous phase so that MABs precipitated spontaneously and undergone complete gelation. Purified MABs were successfully observed by fluorescence microscopy.

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Hyaluronan-Chitosan Polyelectrolytic Complex as a Platform for Delivery of Cytotoxic Agents
University of Minnesota Duluth. Dept Chemical Engineering

Described here is a biomimetic hydrogel adapted to serve as a high concentration, regional delivery system for cytotoxic agents. Paclitaxel was conjugated with low molecular weight hyaluronan to render it water soluble, then embedded in the HCP-h hydrogel for delivey to a culture of C8161 malignant melanoma cells. Live/dead staining of cells was used to monitor effectiveness of paclitaxel release from its HCP-h depot.

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Clinical Evaluation of human embryonic stem cells (hESCs) induced with directed differentiation to gonadotrope cells to cure vasculogenic impotency and to improve coital frequency in males. An open st
University Hospital Malmo Sweden, Stanford Biomed, Inc. Stanford, California, USA, Syed Skin Care, Inc. San Francisco, California, USA

This work demonstrates the clinical efficacy, tolerability and safety of patient-syngenic hESC induced with directed differentiation to gonadotrope cells. Hypothalamus transmits gonadotropin releasing factor to pituitary that sets off LH and FSH to Sertoli cell and Seminiferous tubule resulting Leydig cell to produces testosterone. This potential offers a rationale to evaluate hESCs to cure patients with vasculogenic impotency and to improve coital frequency in males.

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Structure Property Correlation of Bio-nanocomposites
Anasys Instruments Corp

Dimensional similarities between physical characteristics of polymers (such as radius of gyration and lamellar thickness) and nano-sized reinforcing particles lead to the necessity to go beyond filled systems [1] and explore in detail polymer-particle interactions responsible for the improved properties of polymer nanocomposites. Dispersion is a key issue in processing polymer nanocomposites, and has a strong impact on mechanical properties. As opposed to phase separation (more likely to occur w

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Raman Spectroscopy and nano-TA analysis of a Polymer Blend
Anasys Instruments Corp

Characterizing polymer blends can sometimes present a significant challenge for a single technique and the best way is a combination of techniques. In this application note, we discuss an PA6-PET blend which was initially characterized via Raman Spectroscopy at a 500nm spatial resolution. Subsequent thermal characterization at a sub-100nm spatial resolution via the nano-TA revealed a lot of interesting details and more complex sub-structures that were not available from the Raman study and helpe

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Failure Analysis - Identification of Particles in a Polymer Film
Anasys Instruments Corp

Nano-TA is a local thermal analysis technique which combines the high spatial resolution imaging capabilities of atomic force microscopy with the ability to obtain understanding of the thermal behaviour of materials with a spatial resolution of sub-100nm. This breakthrough in spatial resolution of thermal analysis, which is ~50X better than the state of the art, has profound implications for the fields of Polymers and Pharmaceuticals where local thermal understanding is key.

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Heated tip-AFM of nanocomposite Polymer Membranes
Anasys Instruments Corp

Nanocomposite Polymer Membranes: Unlike traditional composite materials whose properties are influenced largely by the constituent components, nanocomposites exhibit such large specific surface areas that interfacial properties can significantly affect bulk behaviour. Poly trimethyl silyl propyne (PTMSP) has garnered attention since its discovery due to its very high permeability, high Tg and exhibited reverse selectivity[1, 2]. However, it was the discovery that the permeability and reverse sel

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Heated Tip-AFM of Energetic Materials: Nano-dectonics
Anasys Instruments Corp

Energetic Materials are materials that exhibit dramatic release of stored chemical energy as thermal and mechanical energies. The primary difference between an energetic material and any material that undergoes a chemical decomposition process is the rate at which the decomposition occurs. The decomposition rate is determined by a number of factors including the particle characteristics (chemical composition, size, morphology), the magnitude and duration of the reaction stimulus, and material co

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Correlation between nanoscale and bulk Thermal Analysis
Anasys Instruments Corp

Thermal methods such as differential scanning calorimetry (DSC) and modulated temperature DSC (MDSC), thermogravimetric analysis (TGA), thermomechanical analysis (TMA), and dynamic mechanical analysis (DMA) are well-established techniques for characterizing the morphology and composition of polymers. It is often possible to identify and quantify materials by reference to their characteristic transition temperatures and thermal stability. However, a serious limitation of conventional thermal meth

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Analyzing Nanoscale inclusions within a Polymer Matrix
Anasys Instruments Corp

Nano-TA is a local thermal analysis technique which combines the high spatial resolution imaging capabilities of atomic force microscopy with the ability to obtain an understanding of the thermal behaviour of materials with a spatial resolution of sub-100nm. This breakthrough in spatial resolution of thermal analysis, which is ~50x better than the state of the art, has profound implications for the fields of polymers and pharmaceuticals where understanding local thermal properties is key.

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Nano-Structure Properties of a Drug Release Coating
Anasys Instruments Corp

HPMC-EC: Blends of hydroxypropyl methylcellulose (HPMC) and ethyl cellulose (EC) are widely used as coatings for solid dosage forms to control drug release rates. This study aimed to map and determine the morphological properties of a phase-separated HPMC/EC blend at the nanometer scale using a new nanothermal analysis (nano-TA) technique, thus providing further understanding of the nature of the intermolecular interactions between the components in the blend.

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Nanobubbles – a New Class of Structure Ready for Exploitation?
NanoSight Ltd

Despite initial scepticism, acceptance of the existence and special properties of nanobubbles is now growing and their formation and characteristics are now becoming the subject of an increasing amount of study, especially in Japan.

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Direct Visualisation, Sizing & Counting of Viruses and Phages in Liquid Suspension
NanoSight Ltd

A new laser-based nanoparticle tracking analysis system is now available which allows nanoscale particles such as viruses and virus aggregates to be directly and individually visualised in liquids in real-time, from which high-resolution particle size distribution profiles can be obtained. The technique is fast, robust, accurate and low cost representing an attractive alternative or complement to existing methods of nanoparticle analysis such as Dynamic Light Scattering (DLS), Photon Correlation

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