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Thursday, September 18, 2014
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ETP Nanomedicine and NANOMED2020: Toward...

Featured Products
Featured Product - Biomarker Discovery & Development
Biomarker Discovery & Development

Webcasts
Webcasts - ETP Nanomedicine and NANOMED2020: Towards a New Nanomedicine HorizonETP Nanomedicine and NANOMED2020: Towards a New Nanomedicine Horizon
Olivier Fontaine, Nanobiotix, speaking at Nanomedicine 2014.
Webcasts - TagLite® 2 cell assay - the next dimension to discovering new antibody drugsTagLite® 2 cell assay - the next dimension to discovering new antibody drugs
Sandra Grau-Richards, Senior Scientist/Team Leader Roche-Glycart

Market Reports
Gene Expression Analysis Market by Technology, Consumables, Services & Applications - Global Forecast to 2018
MarketsandMarkets

Over the years, the gene expression analysis market, comprising of instruments, consumables, and services, has witnessed various technological advancements. These advancements have led to a growth in the number of gene expression applications.
Epigenetic Modification Screening Trends 2014
HTStec

This market report summarizes the results of HTStec’s 3nd industry-wide global web-based benchmarking survey on epigenetic modification screening carried out in May 2014.
Multi-Mode Microplate Reader Trends 2013
HTStec

This market report summarizes the results of HTStec’s 4th industry-wide global web-based benchmarking survey on multi-mode microplate readers carried out in September 2013.
GPCR Screening & Profiling Trends 2013
HTSTec

This market report summarizes the results of HTStec’s 5th industry-wide global web-based benchmarking survey on GPCR screening and profiling carried out in August 2013.
China Pharmaceutical Market Outlook
Global Data

The report details the macroeconomic environment of China, providing a background of the financial and demographic situations in the country, as well as identifying key demographics. It covers the pharmaceutical market broken down by market segment, and the popularity of biosimilars and biologics, identifying where the strongest market potentials lie.
Pathways to Efficient Drug Development - Advances in Modeling and Simulation Outcomes to Fuel Pipeline Productivity
GBI Research

The report examines the reasons why the pharmaceutical industry is looking for improvements in efficiency whilst acknowledging that pharmaceutical R&D remains a long and risky process. It looks in detail at precompetitive research and evaluates how the industry is pulling together to research solutions to problems that are common to all companies.
Drug Discovery and Development Market in Asia
Global Data

The report provides key data, information and analysis of the major trends and issues affecting the drug discovery and development market in seven major countries in Asia, namely China, India, Russia, Japan, Singapore, Taiwan and South Korea.
Biopharmaceutical Manufacturing in India, China and South Korea
GBI Research

The report provides an analysis of biopharmaceuticals approved in 2010 and 2011, operating dynamics in the biopharmaceutical industry, the current scenario in biopharmaceutical manufacturing, key stakeholders, the current market size (2011) of biopharmaceuticals, and forecasts to 2016 for India, China, South Korea and the global market.
Outsourced Ion Channel Testing Trends 2013
HTStec

HTStec's Outsourced Ion Channel Testing Trends 2013 report was published on 3 May 2013. This 58 page market report summarizes the results of HTStec's industry-wide global web-based benchmarking survey on outsourced ion channel testing carried out in April 2013.
Biomarkers in Late-Stage Clinical Trials: Applications, opportunities and activities of leading players
Business Insights

Biomarkers reduce the attrition rate of late-stage clinical trials by assessing drug potential in terms of efficacy and toxicity at the early stages of clinical development. Thus, biomarkers significantly increase productivity, lower the cost and duration of clinical trials, and help researchers complete the drug development process at a faster pace.
Scientific News
Animal Testing can Mislead Drug Discovery and Development
Several blockbuster drugs would not be on the market, if scientists had relied solely on drug-uptake in animal trials, according to new research.
Leukemia Subtype Becomes More Common With Age
Genomic Analysis of 1,725 patients reveals the prevalence of Ph-like ALL increases with age.
Clinical Trial to Test Safety of Stem Cell-Derived Therapy for Type 1 Diabetes
UC San Diego is initial site for first-in-human testing of implanted cell therapy.
NIH to Launch Human Safety Study of Ebola Vaccine Candidate
Trial is First in Series of Accelerated Safety Studies of Ebola Vaccines.
NIH Announces the Launch of 3 Integrated Precision Medicine Trials
ALCHEMIST is for patients with certain types of early-stage lung cancer.
Monthly Blood Transfusions Reduce Sickle Cell Anemia-related Brain Injury in Children
NIH-funded study provides hope for children with disease-related brain damage.
Experimental Chikungunya Vaccine Induces Robust Antibody Response
Vaccine developed by NIH scientists performs well in early clinical trial.
Clinical Trial Evaluates Safety of Stem Cell Transplantation in Spine
Phase I clinical trial is recruiting eight patients for the 5-year study.
First Gene Therapy Trial Launched for Heart Patients with Mechanical Pumps
Patient received new gene therapy at Harefield Hospital, London.
Stem Cells Show Promise for Stroke in Pilot Study
Findings are published in the journal Stem Cells Translational Medicine.
Business News
PAREXEL Expands Perceptive® Partner Program
Life sciences service providers leverage PAREXEL’s eClinical solutions to simplify drug development for customers through technology partnership initiative.
Ovarian Cancer Collaboration with the Medical University of Vienna
Collaboration agreement to investigate the clinical use of the Parsortix system for ovarian cancer.
Quintiles Emerging Biopharma Solution Launched
Quintiles launches new customer solution to meet the unique needs of emerging biopharmaceutical companies.
13th Annual Partnerships in Clinical Trials Congress
The global outsourcing of the clinical trials industry is undergoing a period of rapid growth with research suggesting the market will reach $60.03 billion by 2018.
Cellerant Awarded $47.5 Million Under Existing U.S. Government Contract
Additional funding to support planned phase 2 trial with CLT-008 in AML.
Cancer Research UK, Cancer Research Technology And Asterias Biotherapeutics Partner
Partnership Developed to Trial Immunotherapy Vaccine For Lung Cancer
BGI and The Vancouver Prostate Centre Partner
Partnership announced to create joint research laboratory for advancement of translational cancer research.
DPT Acquires Meda Pharmaceuticals’ Lakewood, New Jersey, Location
Acquisition allow DPT to expand its footprint by adding two buildings.
AbbVie and Calico Announce a Novel Collaboration
Calico to create a leading R&D facility in the San Francisco Bay Area focused on aging and age-related diseases, including neurodegeneration and cancer.
Seattle Genetics and Genmab Enter into New ADC Collaboration
New ADC program will target AXL expressed on multiple tumor types.

Events
Orphan Drugs Market Access and
24 Sep 2014
Orphan Drugs Market Access and ...
More information
Academic Discovery Workshop
23 Sep 2014
Academic Discovery Workshop ...
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2nd Annual Congress of the Eur
22 Sep 2014
2nd Annual Congress of the Eur ...
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Webinar: How to improve your a
01 Oct 2014
Webinar: How to improve your a ...
More information

ePosters
Novel Gpr39 Agonists: Correlation Of Binding Affinity Using Label-Free Back-Scattering Interferometry With Potency In Functional Assays
(1)Molecular Sensing, Inc., Nashville, Tennessee, USA, (2) AstraZeneca Discovery Sciences, Mölndal, Sweden, (3) AstraZeneca CVMD iMED, Mölndal, Sweden

We describe the application of back-scattering interferometry (BSI) to the characterization of small molecule ligand binding to human GPR39 (a GPCR targeted for type-2 diabetes therapy) overexpressed in crude membrane fractions in free solution, including how BSI-derived affinity and functional assay-derived potency correlate for compounds of varying scaffolds.
Mixtures Analysis of Complex Mixtures
Mestrelab Research

We describe an NMR method to quantify mixture components in wine, edible oils, etc. The method is fully customizable, and amenable to high throughput operation.
Novel Gpr39 Agonists: Correlation Of Binding Affinity Using Label-Free Back-Scattering Interferometry With Potency In Functional Assays
(1) Molecular Sensing, Inc., Nashville, Tennessee, USA, (2) AstraZeneca Discovery Sciences, Mölndal, Sweden, (3) AstraZeneca CVMD iMED, Mölndal, Sweden

We describe the application of back-scattering interferometry (BSI) to the characterization of small molecule ligand binding to human GPR39 (a GPCR targeted for type-2 diabetes therapy) overexpressed in crude membrane fractions in free solution, including how BSI-derived affinity and functional assay-derived potency correlate for compounds of varying scaffolds
GC-MS/MS ANALYSIS OF BENZODIAZEPINES USING ANALYTE PROTECTANTS
Thermo Fisher Scientific

Purpose: Assess the feasibility of using analyte protectants to improve the analysis of benzodiazepines.

Targeted cancer therapy based on blocking the expression of genes and small doses of oxaliplatin.
Centre for Medical Genetics Russian Academy of Medical Sciences, Koltsov Institute of Developmental Biology Russian Academy of Sciences

The major drawbacks of the prescribed chemotherapy, are still remain the significant side effects and drug - resistance. Even targeted chemotherapy by means of specific antibodies do not always help to solve these complications. Our purpose was to identify potential biological targets associated with the development of drug resistance and to develop a specific method of suppressing the viability of cancer cells exposed to low doses of standard chemotherapy.
Inverted Y Approach to Lumbosacral region - Analysis of 525 cases over 10 years
Amrita Institute of Medical Sciences

Traditional approach to lumosacral region utilizes midline incision, which often requires long incision to get sufficient exposure. We describe our experience with inverted Y approach to lumbosacral junction.
LC/MS/MS Quantitation of Eicosapentaenoic Acid in Rat Plasma
BASi

Eicosapentaenoic acid (EPA) is an omega-3 fatty acid, which has been documented to be important in biochemical and physiological processes including inflammatory response, blood clotting and the immune system. Eicosapentaenoic acid (EPA) appears in different forms in the blood including triglyceride, ethyl ester, or free acid. In this work we presented an LC/MS/MS method to quantitate the total eicosapentaenoic acid in rat plasma with a 96-well plate format.
Comparison of Dissociated Phoria Measuring Methods. Repeatability and Reliability
CBO

The aim of this study is to determine the reliability and compare reproducibility of different dissociated phoria measure tests.
Secondary Prevention of Stroke: The role of the General Practitioner
NHS

This study aims to review the literature to further elucidate the potential impact of primary care physicians in reducing the burden of stroke.
Participation in “The Airways Program” (TAP) and Associated Mortality Reduction
National Healthcare Group

Research objectives were to assess the impact of “The air way program” on patients length of stay, readmission and mortality.
Application Notes
Cellular Dopamine and Intracellular Calcium Signaling Using the Next Generation HTS Microplate Reader
BMG Labtech

Two cell-based signaling assays from Invitrogen, Fluo-4 Direct™ Calcium Assay and Tango™-bla U2OS GPCR Assay, were performed on the PHERAstar FS HTS instrument. The PHERAstar FS has several unique features that enhance the performance of these assays including direct optic bottom reading, high resolution cell layer scanning, injection at the point of measurement and dual emission detection.
Reaction Optimisation and Large Scale Synthesis
Syrris Ltd

A major benefit of flow chemistry is the ease and consistency of reaction scale up. In a flow reactor, high quality, reproducible mixing, excellent temperature control and superheating are maintained when increasing reaction volume.
Automated Turnkey Solubility and Permeability Assays
Molecular Devices

Millipore Corporation and Molecular Devices have partnered to provide platforms for solubility and permeability screening. The objective is to create automation-compatible 96- and 384-based systems with pre-validated methods, devices and analysis that can be run manually or in conjunction with standard laboratory automation.
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