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  Events - March 2013

NGS for Drugs, Patients and Clinical Trials

21 Mar 2013 - 22 Mar 2013 - San Diego, CA, USA

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Next-Generation Sequencing (NGS) is poised to revolutionize the drug discovery paradigm by offering unprecedented interrogation of the human genome at high resolution and relatively low costs. While the widespread implementation of NGS is apparent, issues specific to drug development present new challenges for developers.  Join Cambridge Healthtech Institute for NGS for Drugs, Patients and Clinical Trials and explore the unparalleled advantages and arising challenges in using NGS technologies for translational research.                                                                                                                                                           

Discussions will cover:

  • NGS for Decision Making During Drug Development and Clinical Trials
  • Developing Informatics Infrastructure & Pipelines to Handle Complex NGS Data
  • Navigating Regulatory Hurdles of Informed Consent and Data Sharing
  • Harnessing NGS Technologies for Identification of Causal Variants and "Driver" Mechanisms in Disease

Featured presentations include:

Profiling and NGS in Cancer: Challenges and Applications to Targets, Models, and Resistance

Paul Rejto, Ph.D., Director, Computational Biology, Oncology Research Unit, Pfizer, Inc.

Devising Methods for Intuitively Handling Huge Data Sets to Simplify Biomarker Discovery

Dongliang Ge, Ph.D., Director, Bioinformatics, Gilead Sciences, Inc.

Further information
Scientific News
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NIH-funded clinical trial marks first major advance in therapy in 40 years.
Blocking the Transmission Of Malaria Parasites
Vaccine candidate administered for the first time in humans in a phase I clinical trial led by Oxford University’s Jenner Institute, with partners Imaxio and GSK.
First Therapy Appearing to Reverse Decline in Parkinson’s
An FDA-approved drug for leukemia improved cognition, motor skills and non-motor function in patients with Parkinson’s disease and Lewy body dementia in a small clinical trial, say researchers at Georgetown University Medical Center (GUMC).
Gene Therapy Staves Off Blindness from Retinitis Pigmentosa in Canine Model
NIH-funded study suggests therapeutic window may extend to later-stage disease.
Treatment for Rare Bleeding Disorder is Effective
Researchers in Manchester have demonstrated for the first time the relative safety and effectiveness of treatment, eltrombopag, in children with persistent or chronic immune thrombocytopenia (ITP), as part of an international duo of studies.
HIV Vaccine Human Trials Begin
Baltimore-based Institute has begun enrolling volunteers for initial phase 1 clinical trials.
New Therapy Reduces Symptoms of Inherited Enzyme Deficiency
A phase three clinical trial of a new enzyme replacement medication, sebelipase alfa, showed a reduction in multiple disease-related symptoms in children and adults with lysosomal acid lipase deficiency, an inherited enzyme deficiency that can result in scarring of the liver and high cholesterol.
Fixing Holes in the Heart Without Invasive Surgery
UV-light enabled catheter is a medical device which represents a major shift in how cardiac defects are repaired.
Atriva Therapeutics GmbH Develops Innovative Flu Drug
Highly effective against seasonal and pandemic influenza.
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