Corporate Banner
Satellite Banner
Pharma Outsourcing
Scientific Community
Become a Member | Sign in
Home>News>This Article

New Taste-Masking Technologies Facilitate User-Friendly Pharmaceuticals

Published: Wednesday, September 12, 2012
Last Updated: Wednesday, September 12, 2012
Bookmark and Share
Hermes Pharma, INNOJET Herbert Hüttlin, RCPE and Karl Franzens University research new approaches to increase patient compliance and improve production processes.

Hermes Pharma has announced the start of a research project with the Research Center Pharmaceutical Engineering GmbH(RCPE), INNOJET Herbert Hüttlin and the Karl Franzens University.

The goal of the project is to jointly develop new pharmaceutical formulations and design manufacturing processes accordingly.

The scope of the project includes developing new approaches to masking unpleasant taste and smell of active pharmaceutical ingredients (APIs) which patients often experience when pharmaceuticals dissolve in the mouth.

The four partners plan to develop new technologies to coat APIs with lipids and simultaneously overcome the drawbacks of conventional production processes.

The research spans formulation development to the design and implementation of new production processes.

A special focus will be on achieving greater efficiency through shorter processing times by developing techniques that eliminate the use of solvents, and by increasing yields.

Lengthy process cycles and elaborate coating make processing complex and expensive
In the pharmaceutical industry, coating with polymethacrylate or with modified cellulose is state-of-the-art. The disadvantage of this process is that an enormous amount of solvents must be used, but only for processing purposes.

The coating of active agent particles with lipids as part of the hot melt coating process is, in comparison, a less costly and more innovative approach to masking the unpleasant taste inherent in APIs.

Because solvents are not needed when coating with lipids, process cycle times are shortened and sub coating of particles or tablets for isolating purposes becomes redundant.

However, coating with lipids presents other challenges: According to Prof. Dr. Andreas Zimmer of the Institute for Pharmaceutical Sciences of the University of Graz (Austria), such coatings are often associated with release and stability problems, as during shelf life unwanted changes in polymorphic form can occur.

The characterization of lipids and stability projection are therefore prerequisites for the successful development of pharmaceuticals which incorporate unpleasant substances and dissolve in the mouth.

The goal: To obtain new formulations and develop novel process techniques
“The goal of the research project is to obtain a basic understanding of the crystallization processes during coating and storage of the final products,“ said Dr. Sharareh Salar-Behzadi, Senior Researcher at the RCPE. “As a result, we will be able to predict polymorphic changes better and develop formulations which guarantee not only the required release profile but also effective taste masking over the entire shelf life of the product.”

In addition to highly product-oriented research, the team aims to concentrate on the implementation of new technical processes in production.

At the onset of the research project, the selection of the most suitable process technologies was undertaken so that scale up of the formulation from lab settings to larger facilities can be transitioned easily.

Part of this technology selection involved the development of a PAT (Process Analytical Technology) solution for direct in-process measurement of critical product attributes.

In conjunction with PAT, the development of a solution is being considered which provides direct real-time information about the chemical composition of the product, for example, the coating layer thickness or water content.

It is expected that critical process and quality attributes such as the duration of the process, temperature, spray and release rates could then be predicted more accurately.

The concept of Quality by Design (QbD), the pursuit of a holistic approach to product lifecycle, will serve as the link between product and process development. Appropriate process technologies will be embedded early in order to produce high quality pharmaceutical products profitably.

The researchers plan to take production process steps into account - even in the product development phase. The partners aim to substitute to a large extent post production quality control and analytics for in-process measurements with corresponding process control, and expect to obtain related cost savings.

Four specialists intent on achieving one goal
“Hermes Pharma is the expert in the development and production of user-friendly dosage forms,” said Dr. Detlev Haack, Head of R&D, Hermes Pharma. “In order to provide solutions at every point along the entire pharmaceutical value chain, we engage time and again in the first steps of research and development. We drive innovative technologies which are incorporated into our products and services and provide our customers with a competitive advantage.”

Hermes Pharma has selected three partners for this project: INNOJET Herbert Hüttlin will be supporting the project with its technical expertise in coating and granulation of solid substances, and providing an INNOJET VENTILUS® Fluid Bed System.

The latter has already been pre-installed with a hot melt unit. Through linear up-scaling, the advanced equipment will facilitate the implementation of PAT. The underlying internationally-patented Air Gliding Technology was developed by Dr. h.c. Herbert Hüttlin.
As a non-university research organization, the RCPE will be providing technical knowledge related to pharmaceutical process and product development.

The Karl Franzens University Graz will be supporting the development of new formulations with scientific know-how. “Close networking between higher education and industry is important, not only when ground-breaking ideas are developed but when they are implemented for customer solutions,” emphasized Dr. h.c. Herbert Hüttlin, General Manager and founder of INNOJET Herbert Hüttlin.

The research project will be carried out by the partner specialists in Graz at the RCPE and at the Karl Franzens University. The initial findings are expected mid 2013.

Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,800+ scientific posters on ePosters
  • More than 4,000+ scientific videos on LabTube
  • 35 community eNewsletters

Sign In

Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Scientific News
Lucentis Effective for Proliferative Diabetic Retinopathy
NIH-funded clinical trial marks first major advance in therapy in 40 years.
Blocking the Transmission Of Malaria Parasites
Vaccine candidate administered for the first time in humans in a phase I clinical trial led by Oxford University’s Jenner Institute, with partners Imaxio and GSK.
First Therapy Appearing to Reverse Decline in Parkinson’s
An FDA-approved drug for leukemia improved cognition, motor skills and non-motor function in patients with Parkinson’s disease and Lewy body dementia in a small clinical trial, say researchers at Georgetown University Medical Center (GUMC).
Gene Therapy Staves Off Blindness from Retinitis Pigmentosa in Canine Model
NIH-funded study suggests therapeutic window may extend to later-stage disease.
Treatment for Rare Bleeding Disorder is Effective
Researchers in Manchester have demonstrated for the first time the relative safety and effectiveness of treatment, eltrombopag, in children with persistent or chronic immune thrombocytopenia (ITP), as part of an international duo of studies.
HIV Vaccine Human Trials Begin
Baltimore-based Institute has begun enrolling volunteers for initial phase 1 clinical trials.
New Therapy Reduces Symptoms of Inherited Enzyme Deficiency
A phase three clinical trial of a new enzyme replacement medication, sebelipase alfa, showed a reduction in multiple disease-related symptoms in children and adults with lysosomal acid lipase deficiency, an inherited enzyme deficiency that can result in scarring of the liver and high cholesterol.
Fixing Holes in the Heart Without Invasive Surgery
UV-light enabled catheter is a medical device which represents a major shift in how cardiac defects are repaired.
Atriva Therapeutics GmbH Develops Innovative Flu Drug
Highly effective against seasonal and pandemic influenza.
Study Removes Cancer Doubt for Multiple Sclerosis Drug
Researchers from Queen Mary University of London are calling on the medical community to reconsider developing a known drug to treat people with relapsing Multiple sclerosis after new evidence shows it does not increase the risk of cancer as previously thought.
Scroll Up
Scroll Down

Skyscraper Banner
Go to LabTube
Go to eposters
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,800+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,000+ scientific videos