Corporate Banner
Satellite Banner
Pharma Outsourcing
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Dezima In-Licenses CETP Inhibitor Program from MTPC

Published: Thursday, April 25, 2013
Last Updated: Thursday, April 25, 2013
Bookmark and Share
World-renowned dyslipidemia experts join Dezima’s Scientific Advisory Board.

Dezima Pharma (‘Dezima’) has announced the in-licensing of a cholesteryl ester transfer protein (CETP) inhibitor DEZ-001 (formerly TA-8995) from Mitsubishi Tanabe Pharma Corporation (MTPC). Terms of the deal were not disclosed.

DEZ-001 has completed single and multiple ascending dose studies showing an unprecedented effect on high density lipoprotein (HDL) and low density lipoprotein (LDL) levels in healthy volunteers with a very favourable side-effect profile.

The company plans to support clinical development of DEZ-001 to Phase 3 clinical trials.

Professor John Kastelein, founder of Dezima, co-founder of UniQure and advisor to Forbion Capital Partners, identified DEZ-001 as a potentially best-in-class, potent and safe CETP inhibitor.

At the same time, Dezima also reported the strengthening of its Scientific Advisory Board (SAB) with the addition of two world-leading experts in the dyslipidemia space: Dr Philip Barter, President of the International Atherosclerosis Society and Conjoint Professor at The University of New South Wales, Sydney, Australia, and Dr Bryan Brewer, Director at Washington Cardiovascular Associates and Senior Research Consultant of Lipoprotein and Atherosclerosis Research at the Medstar Research Institute, Washington DC, USA.

Professor Kastelein, Dezima’s CSO and Chairman of its SAB, commented: “CETP inhibitors hold enormous potential to further normalize lipid levels in millions of dyslipidemic patients worldwide. This product was a compelling in-licensing prospect because of its promising early clinical efficacy and safety profile. By applying a smart development program, DEZ-001 could potentially enter the market at a time similar to competing CETP inhibitors.”

Sander van Deventer, Dezima’s interim-CEO and General Partner at Forbion Capital Partners, who seed-financed Dezima together with BioGeneration Ventures, added: “The dyslipidemia space represents an attractive investment opportunity due to the continued high unmet medical need and the introduction of several next-generation therapeutic approaches. The addition of these two renowned experts to Dezima’s SAB will support the company in advancing DEZ-001, and in helping to identify additional earlier-stage dyslipidemia assets in order to develop a range of promising therapies in the CVD field.”


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,500+ scientific posters on ePosters
  • More than 5,000+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Dezima Reports Positive Results in its Phase 2b TULIP Trial
Combines outstanding efficacy and safety profile with favourable pharmacokinetics.
Saturday, August 30, 2014
Dezima Extends Clinical Development Program for its CETP Inhibitor TA-8995
Phase 2b TULIP study readout in August 2014, new Lipoprotein(a) study approved.
Thursday, July 10, 2014
Dezima Completes Patient Enrolment for TULIP Phase 2b Study
Aim of the study is to investigate the effects of TA-8995 in mild dyslipidemia patients.
Monday, January 13, 2014
Dezima Initiates Phase 2b TULIP Study on CETP Inhibitor Program DEZ-001
TULIP study will investigate the effects of different doses of DEZ-001 on CVD biomarkers.
Friday, August 30, 2013
Dezima Pharma Appoints Seasoned New CEO
Appointment of Rob de Ree as Company’s new Chief Executive Officer.
Thursday, June 13, 2013
Scientific News
Advanced Lymphoma in Remission After T-Cell Therapy
63% of trial participants who recieved two-drug combination chemo plus intermediate dose of engineered T cells went into complete remission.
New Treatment for Immune Cancers
Clinical trial shows new drug holds promise for treating advanced mastocytosis.
Sickle Cell Gene Therapy Passes Test
Researchers found a precision-engineered gene therapy virus reduced sickle-induced red-cell damage in mice with sickle cell disease.
Opening Door to Oesophageal Cancer Targeted Treatments
Scientists have discovered that oesophageal cancer can be classified into three different subtypes.
Inovio Launches Zika Vaccine Trial
Inovio launches Zika vaccine trial in midst of Puerto Rico epidemic to explore early signals of vaccine efficacy.
Vitamin C May Boost Leukemia Treatment
Studies show that supplementing an epigenetic cancer drug with vitamin C enhanced the drug's effectiveness.
New Hope for Zika Treatment Found in Large-Scale Screen of Existing Drugs
Johns Hopkins researchers join collaborative group to screen 6,000 existing drugs in hopes of finding treatments for Zika Virus infection
FINCH Filgotinib Phase 3 Program Initiated
Galapagos NV reports the initiation of the FINCH global Phase 3 program in rheumatoid arthritis patient populations.
Stem Cell Therapy Heals Injured Mouse Brain
A team of researchers has developed a therapeutic technique that dramatically increases the production of nerve cells in mice with stroke-induced brain damage.
Zika Vaccine Testing in Humans
The NAAID has initiated a clinical trail of a vaccine candidate for the prevention of the Zika virus infection.
Scroll Up
Scroll Down
SELECTBIO

SELECTBIO Market Reports
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,500+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
5,000+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!