Corporate Banner
Satellite Banner
Pharma Outsourcing
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Plexpress Announces ADME-Tox Programs for CRO’s

Published: Friday, May 03, 2013
Last Updated: Friday, May 03, 2013
Bookmark and Share
EMA and FDA recommend mRNA testing in ADME-Tox studies for superior sensitivity.

Plexpress has announced dedicated ADME-Tox programs for contract research organizations (CROs). This follows FDA draft guidance suggesting measurement of CYP mRNA levels for ADME-Tox studies, and EMA final guidelines stating that mRNA analysis should be used in drug interaction studies in order to increase the sensitivity of assays.

Plexpress has developed two ADME-Tox screening services for CROs to ensure compliance with regulatory guidelines. For the early screening of compounds of interest, the TRACPACK CYP+ mRNA Screening Service quickly and efficiently identifies unsuitable compounds, allowing them to ‘fail early’ before further time and money is invested.

This service specifically analyzes mRNA expression of the key ADME-Tox markers in a time and cost-effective manner. Plexpress’ TRACPACK INDUCTION, has been developed for the in-depth screening of high priority drug candidates generating data that completely fulfills the global guidelines.

TRACPACK INDUCTION measures both mRNA expression and enzyme activity, using hepatocytes from three different donors.

TRAC’s unique multiplexing with high sample throughput fills the gap between microarrays and traditional targeted approaches such as qPCR, offering numerous time, cost and accuracy benefits to alternative methods.

Plexpress is offering two easy ways for CRO’s to incorporate TRAC into their workflow. The Plexpress Partner Program, an outsourced service which is ideal for small to medium throughput, and the Plexpress Licensing Program suited to a higher throughput with TRAC assays undertaken in-house by the CRO.

Dr. Jari Rautio, CEO of Plexpress, said: “In light of recent recommendations, drug companies are requesting mRNA data for CYP targets to fulfill regulatory guidelines. Our TRAC CRO services and products have been designed to fulfill this exact need and are highly attractive tools thanks to the numerous benefits they offer in comparison to other technologies. TRAC combines gene multiplexing with high sample throughput to increase assay speed and minimize technical variation, providing significant economic and efficiency boosts. We have made it easy for CROs to incorporate TRAC into their workflow with our dedicated Plexpress Partner Program and Plexpress Licensing Program allowing them the choice of outsourcing or fully supported in-house set-up.”


Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,500+ scientific posters on ePosters
  • More than 3,700+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.


Scientific News
NIH Study Finds Calorie Restriction Lowers Some Risk Factors for Age-Related Diseases
Two-year trial did not produce expected metabolic changes, but influenced other life span markers.
Immunotherapy Agent Benefits Patients with Drug-Resistant Multiple Myeloma in First Human Trial
Daratumumab proved generally safe in patients, even at the highest doses.
NIH Study Shows No Benefit of Omega-3 Supplements for Cognitive Decline
Research was published in the Journal of the American Medical Association.
NIH Launches Human RSV Study
Study aims to understand infection in healthy adults to aid development of RSV medicines, vaccines.
Computerized Flexible Needles Prove Themselves in Biological Tissue
The advantage of the system is that you can avoid obstacles with the needles or critical tissues and that the system during the insertion of the needle in real time can adjust the path if, for example, the tissue deforms.
DARWIN 2 24-week Monotherapy Data in RA Confirm Previous Results
Safety profile in DARWIN 2 consistent with previous filgotinib RA studies.
Researchers Publish Landmark “Basket Study”
Researchers from Memorial Sloan Kettering Cancer Center (MSK) have announced results from the first published basket study, a new form of clinical trial design that explores responses to drugs based on the specific mutations in patients’ tumors rather than where their cancer originated.
Agricultural Intervention Improves HIV Outcomes
A multifaceted farming intervention can reduce food insecurity while improving HIV outcomes in patients in Kenya, according to a randomized, controlled trial led by researchers at UC San Francisco.
Overdose of Vitamin D in Teenagers May Lead to Increased Cholesterol Levels
Dosing obese teens with vitamin D shows no benefits for their heart health or diabetes risk, and could have the unintended consequences of increasing cholesterol and fat-storing triglycerides. These are the latest findings in a series of Mayo Clinic studies in childhood obesity.
Phase 2 Trials Underway for New Single Dose Malaria Treatment
The new drug, which prevents the malaria parasite from reproducing and spreading, is now undergoing Phase II clinical trials in humans.
Scroll Up
Scroll Down
SELECTBIO

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,500+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
3,700+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FREE!