Corporate Banner
Satellite Banner
Pharma Outsourcing
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Patient Enrollment is a Critical Cost Driver in Phase 1 Clinical Trials

Published: Wednesday, June 19, 2013
Last Updated: Wednesday, June 19, 2013
Bookmark and Share
Cutting Edge Information’s recent study of oncology trials revealed a strong correlation between number of patients and trial cost.

Both the number of patients and trial duration heavily impact a Phase 1 oncology trial’s total cost. The underlying force driving most costs is patient enrollment. As the time to reach full enrollment increases, the trial lasts longer and the cost of maintaining and staffing clinical sites rises.

Cutting Edge Information’s study “Oncology Clinical Trials: Drug Development Resources and Case Studies” discovered that for Phase 1 clinical trials, patient enrollment ranges from 25 to 97 patients with an average of 47.8 patients. As the patient pool increases, trial costs rise as well. Trials enrolling 40 or fewer patients report an average cost of $2.7 million. Trials enrolling more than 40 patients report an average cost of $7.6 million.

The Phase 1 oncology trials included in the study reported very little variability in the average planned and actual enrollments. The planned and actual enrollment numbers differ on average by fewer than two patients. Additionally, Phase 1 is the only phase to report small increases from planned to actual patient enrollment.

“Overall, the trend shows an increase in trial costs with increasing patient enrollment,” said Ryan McGuire research team leader at Cutting Edge Information. “The correlation coefficient between number of patients and trial cost is relatively strong. The expected patient enrollment helps a clinical program leader gauge the total cost of the trial. Higher enrollment generally requires more time, staff and site.”

“Oncology Clinical Trials: Drug Development Resources and Case Studies” features detailed oncology clinical development data including specific methods for best allocating resources in Phase 3. The research also highlights up-to-date metrics illustrating oncology clinical trial costs, one of the largest areas of study for the pharmaceutical industry. Drug companies that manufacture oncology medicines can use this report to:

•    Explore areas of higher activity for different types of cancer drug development.
•    Determine the cost per patient and other critical cost drivers for different types of oncology clinical trials.
•    Compare predicted and actual patient enrollment metrics of 30 oncology clinical trials from Phase 1 to Phase 3.


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,500+ scientific posters on ePosters
  • More than 5,000+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

New Product Planning Spend Up to Half their Time on BD
A new survey of drug manufacturers found that new product planning teams dedicate upwards of 50% of their time on business development activities.
Tuesday, January 29, 2013
Central and Eastern Europe Building Clinical Trial Success
Development teams benefit from tougher investigator standards and active patient populations, finds Cutting Edge Information.
Monday, February 14, 2011
Scientific News
Advanced Lymphoma in Remission After T-Cell Therapy
63% of trial participants who recieved two-drug combination chemo plus intermediate dose of engineered T cells went into complete remission.
New Treatment for Immune Cancers
Clinical trial shows new drug holds promise for treating advanced mastocytosis.
Sickle Cell Gene Therapy Passes Test
Researchers found a precision-engineered gene therapy virus reduced sickle-induced red-cell damage in mice with sickle cell disease.
Opening Door to Oesophageal Cancer Targeted Treatments
Scientists have discovered that oesophageal cancer can be classified into three different subtypes.
Inovio Launches Zika Vaccine Trial
Inovio launches Zika vaccine trial in midst of Puerto Rico epidemic to explore early signals of vaccine efficacy.
Vitamin C May Boost Leukemia Treatment
Studies show that supplementing an epigenetic cancer drug with vitamin C enhanced the drug's effectiveness.
New Hope for Zika Treatment Found in Large-Scale Screen of Existing Drugs
Johns Hopkins researchers join collaborative group to screen 6,000 existing drugs in hopes of finding treatments for Zika Virus infection
FINCH Filgotinib Phase 3 Program Initiated
Galapagos NV reports the initiation of the FINCH global Phase 3 program in rheumatoid arthritis patient populations.
Stem Cell Therapy Heals Injured Mouse Brain
A team of researchers has developed a therapeutic technique that dramatically increases the production of nerve cells in mice with stroke-induced brain damage.
Zika Vaccine Testing in Humans
The NAAID has initiated a clinical trail of a vaccine candidate for the prevention of the Zika virus infection.
Scroll Up
Scroll Down
SELECTBIO

SELECTBIO Market Reports
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,500+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
5,000+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!