Corporate Banner
Satellite Banner
Pharma Outsourcing
Scientific Community
Become a Member | Sign in
Home>News>This Article

Clasado and University of Oxford Demonstrate Effect of Prebiotics on Brain and Gut

Published: Monday, January 27, 2014
Last Updated: Monday, January 27, 2014
Bookmark and Share
Study results provide positive data for ongoing human trials.

Clasado and The Department of Psychiatry, University of Oxford have announced the results of pre-clinical research demonstrating prebiotics affect the relationship between the gut and the brain. This collaborative research will complement and serve as a precursor to current human trials.

The research was supported by funding provided by the Biotechnology, Biological Sciences, Research Council (BBSRC).

The research showed for the first time that the modulation of gut microbiota by prebiotics can lead to changes in brain biochemistry. The study is published in the journal Neurochemistry International, entitled ‘Prebiotic feeding elevates central brain derived neurotrophic factor, N-methyl-D-aspartate receptor subunits and D-serine’.

The researchers hope that the findings could offer insight into the potential treatment of cognitive dysfunction, emotional disturbances in neuropsychiatric illness and age related decline.

In the trial, rats were fed either FOS (fructo-oligosaccahride) or second generation GOS (galacto-oligosaccharide) prebiotics (Bimuno). In both cases significant effects on the neuronal biochemistry of the rats were demonstrated. These effects are believed to have resulted from changes in the gut microbiota including an increase in bifidobacteria facilitated via the feeding of prebiotics.

Brain Derived Neurotrophic Factor (BDNF), an important molecule involved in the development and maintenance of neural cells, increased in the brain after repeated ingestion of prebiotics, compared with rats that did not receive the prebiotics.

Additionally, components of the N-methyl-D-aspartate (NMDA) receptor, which have a critical role in brain development, learning and memory, also increased in the rat brain after just two weeks of daily prebiotic feedings.

Second generation GOS intake, which induced the greatest elevation of bifidobacteria compared to FOS and controls led to an increase of NR1 and NR2A subunits in the hypocampus and NR1 subunits and D-serine in the frontal cortex.

The administration of FOS, which caused a relatively minor proliferation of bifidobacteria, increased the levels of NR1 in the hypocampus only. However, FOS administration also raised the concentration of hippocampal BDNF, an effect previously observed with probiotics.

Further studies will determine whether the increase in NMDA and BDNF were as a result of factors other than only microbiota. This is because there is some evidence suggesting that 2nd generation prebiotics such as Bimuno may also interact directly with the gut. Further research is also needed to test whether the changes seen in the rat brain translate to improved neural function and behaviour, and whether prebiotics can benefit human brain health.

“The study has provided valuable insights into the complex interactions between the gut and brain,” said Dr Phil Burnet, head researcher, University Department of Psychiatry, University of Oxford. “Our results have also provided the basis for further research in humans.”

“There is a growing body of evidence linking the gut to various aspects of brain health,” said Geoff Collins, Head of Consumer Marketing, Clasado. “We are hopeful that this new research, the first of its kind using a prebiotic, will pave the way for further discoveries and potential brain associated health applications for this technology.”

Human clinical trials have recently been conducted by Clasado and The Department of Psychiatry, University of Oxford. Enrolment for this study was completed in Q4, 2012 with the study itself having been completed at the end of 2013. The results of the study are due to be published in the coming months.

Prebiotic technology could prove to be a useful contribution to the management and treatment of depressive disorders, particularly as unlike some existing drug therapies it is free from unwanted side effects. Clasado hopes to demonstrate that the addition of specific prebiotics to the diet of an ageing population could hold real benefits in ensuring an improved quality of life.

Clasado is seeking partnerships on an ongoing basis with Research Centres, Institutions and Companies who have an interest in human health.

Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,600+ scientific posters on ePosters
  • More than 3,800+ scientific videos on LabTube
  • 35 community eNewsletters

Sign In

Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Clasado Announces Positive Results of Clinical Study of Bimuno® for Metabolic Syndrome
Results will be published in the March 2013 issue of The Journal of Nutrition.
Friday, February 15, 2013
Scientific News
Fixing Holes in the Heart Without Invasive Surgery
UV-light enabled catheter is a medical device which represents a major shift in how cardiac defects are repaired.
Atriva Therapeutics GmbH Develops Innovative Flu Drug
Highly effective against seasonal and pandemic influenza.
Study Removes Cancer Doubt for Multiple Sclerosis Drug
Researchers from Queen Mary University of London are calling on the medical community to reconsider developing a known drug to treat people with relapsing Multiple sclerosis after new evidence shows it does not increase the risk of cancer as previously thought.
Antibody Treatment Efficacious in Psoriasis
An experimental, biologic treatment, brodalumab, achieved 100 percent reduction in psoriasis symptoms in twice as many patients as a second, commonly used treatment, according to the results of a multicenter clinical trial led by Mount Sinai researchers.
Scientists Test New Gene Therapy for Vision Loss from a Mitochondrial Disease
NIH-funded study shows success in targeting mitochondrial DNA in mice.
HIV Patients Should Be Included in Early Clinical Trials of Anti-TB Drugs
Tuberculosis is the number one cause of death in HIV-infected patients in Africa and a leading cause of death in this population worldwide.
Multi-Gene Test Enables Some Breast Cancer Patients to Safely Avoid Chemotherapy
A major study is providing the best evidence to date that a 21-gene test done on the tumor can identify breast cancer patients who can safely avoid chemotherapy.
Low Dose Beta-Blockers As Effective As High Dose After a Heart Attack?
Heart attack patients live as long – or even longer – on one-quarter the suggested dose.
Antidepressants Plus Blood-Thinners Slow Down Brain Cancer
EPFL scientists have found that combining antidepressants with anticoagulants slows down brain tumors (gliomas) in mice.
Old Drug Performs New Tricks
Cambridge-led research reveals the powers of a "wonder drug" that has lain under the noses of doctors for 50 years.
Scroll Up
Scroll Down

Skyscraper Banner
Go to LabTube
Go to eposters
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,600+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
3,800+ scientific videos