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Aspireo Reports Data in Further Phase Ib Study

Published: Tuesday, April 22, 2014
Last Updated: Tuesday, April 22, 2014
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Somatoprim demonstrates superior side effect profile over octreotide.

Aspireo Pharmaceuticals Limited has reported final data from a further phase Ib study in healthy volunteers.

In this single-dose, randomized, 5-way cross-over study, healthy volunteers were treated with the highest approved dose of octreotide, three different doses of Somatoprim (DG3173) and placebo control.

The main purpose of the study was to investigate the effects of each treatment on the control of plasma glucose as well as the secretion of insulin and glucagon following a standard meal.

The final data demonstrate that octreotide significantly inhibits the secretion of insulin and glucagon in humans and shows a significant and sustained increase of plasma glucose levels.
In contrast, DG3173 has much less of an effect on insulin and glucagon release compared to octreotide, as well as the normalization of glucose control. This improved profile was observed even at high doses of DG3173.

Carsten Dehning, CEO of Aspireo Pharmaceuticals said: ”This study clearly demonstrates the superiority in the side effect profile of DG3173 over octreotide. These results confirm the findings from pre-clinical studies and support the unique profile of this promising investigational drug with respect to glycaemic control.”


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