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Monday, September 01, 2014
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GC-MS/MS ANALYSIS OF BENZODIAZEPINES USING ANALYTE PROTECTANTS
Jeremy Matthews, Alex Chen, Flavio Bedini

Purpose: Assess the feasibility of using analyte protectants to improve the analysis of benzodiazepines.

Targeted cancer therapy based on blocking the expression of genes and small doses of oxaliplatin.
Bavykin A.S.1, Korotaeva A.A.1, Poyarkov S.V.2, Syrtsev A.V.1, Karpukhin A.V.1

The major drawbacks of the prescribed chemotherapy, are still remain the significant side effects and drug - resistance. Even targeted chemotherapy by means of specific antibodies do not always help to solve these complications. Our purpose was to identify potential biological targets associated with the development of drug resistance and to develop a specific method of suppressing the viability of cancer cells exposed to low doses of standard chemotherapy.

Inverted Y Approach to Lumbosacral region - Analysis of 525 cases over 10 years
Dr Krishna Kumar and Dr Renjith Kumar

Traditional approach to lumosacral region utilizes midline incision, which often requires long incision to get sufficient exposure. We describe our experience with inverted Y approach to lumbosacral junction.

LC/MS/MS Quantitation of Eicosapentaenoic Acid in Rat Plasma
Rachel Sun, Jordan Nally, Tim Shoaf

Eicosapentaenoic acid (EPA) is an omega-3 fatty acid, which has been documented to be important in biochemical and physiological processes including inflammatory response, blood clotting and the immune system. Eicosapentaenoic acid (EPA) appears in different forms in the blood including triglyceride, ethyl ester, or free acid. In this work we presented an LC/MS/MS method to quantitate the total eicosapentaenoic acid in rat plasma with a 96-well plate format.

Comparison of Dissociated Phoria Measuring Methods. Repeatability and Reliability
Ane Murueta-Goyena Larrañaga

The aim of this study is to determine the reliability and compare reproducibility of different dissociated phoria measure tests.

Secondary Prevention of Stroke: The role of the General Practitioner
Rayna Patel

This study aims to review the literature to further elucidate the potential impact of primary care physicians in reducing the burden of stroke.

Participation in “The Airways Program” (TAP) and Associated Mortality Reduction
Pradeep Paul George, Bee Hoon Heng, Mavis Yeow Bee Ling, Loo See Yeow, Fong Seng Lim, Lim Tow Keang

Research objectives were to assess the impact of “The air way program” on patients length of stay, readmission and mortality.

Random Homozygous Gene Perturbation (RHGP) as a Tool for Target Discovery and Validation
Wu-Bo Li and Michael Goldblatt

Random homozygous gene perturbation (RHGP) can identify and validate any host (cellular) gene target that directly causes a desired phenotype without requiring prior knowledge of the target. The central feature of RHGP is a unique lentiviral-based genetic element, known as a gene search vector (GSV) designed to interrogate the entire genome and identify target genes that cause the phenotype of interest.

Gene expression analysis of CD14+ monocytes immunomagnetically separated directly from whole blood: adaptation of protocols towards clinical trial requirements
Gregor Winkels1, Ines Dischinger1, Katharina Bublitz1, Evert Luesink2, Nanguneri R. Nirmala2, Frank Staedtler2, Keith J. Johnson2, Alena Fitz1, Sabrina Schmitz1, Dirk Dietrich1, Sonja Balzer1, Sabine Classen1, Silvia Rüberg1, Uwe Janssen1, and Bernhard Gerstmayer1

Peripheral blood is widely used as starting material for biomarker discovery and validation using molecular biology technologies. The vast majority of currently published transcriptome data is based on RNA derived either from stabilized whole blood or peripheral blood mononuclear cells (PBMCs). Here, gene expression profiling studies and SOPs for fast, easy and specific manual or automated isolation of monocytes directly from whole blood are being described.

Quality Standards for 14C API for use in human clinical studies
I Shaw, G Johnston, K Dare, D Dams

The Good Manufacturing Practice (GMP) state that the active pharmaceutical ingredient (API) intended for use in early stage clinical trials should be of "suitable" quality. The Clinic Ready quality standard ensures that the API is synthesised with all the appropriate documentation to facilitate QP release of the final IMP for guman clinical dosing.

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Showing Results 1 - 10 of 39
Scientific News
NIH to Launch Human Safety Study of Ebola Vaccine Candidate
Trial is First in Series of Accelerated Safety Studies of Ebola Vaccines.
NIH Announces the Launch of 3 Integrated Precision Medicine Trials
ALCHEMIST is for patients with certain types of early-stage lung cancer.
Monthly Blood Transfusions Reduce Sickle Cell Anemia-related Brain Injury in Children
NIH-funded study provides hope for children with disease-related brain damage.
Experimental Chikungunya Vaccine Induces Robust Antibody Response
Vaccine developed by NIH scientists performs well in early clinical trial.
Clinical Trial Evaluates Safety of Stem Cell Transplantation in Spine
Phase I clinical trial is recruiting eight patients for the 5-year study.
First Gene Therapy Trial Launched for Heart Patients with Mechanical Pumps
Patient received new gene therapy at Harefield Hospital, London.
Stem Cells Show Promise for Stroke in Pilot Study
Findings are published in the journal Stem Cells Translational Medicine.
Transplanting Gene into Injured Hearts Creates Biological Pacemakers
Researchers develop first minimally invasive gene therapy procedure to treat heart rhythm disorders by transforming ordinary heart muscle cells into specialized rhythm-keeping cells, potentially eliminating future need for electronic pacemakers.
Rehabilitation Helps Prevent Depression from Age-Related Vision Loss
NIH-funded study brought together eye care and mental health professionals.
Major Cystic Fibrosis Breakthrough
Combination of ivacaftor with lumicaftor improves lung function and reduces patients hospitalizations.
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