|Mixtures Analysis of Complex Mixtures|
Michael Bernstein; Carlos Cobas; Santi Domínguez; Manuel Pérez; Agustín Barba
We describe an NMR method to quantify mixture components in wine, edible oils, etc. The method is fully customizable, and amenable to high throughput operation.
|Novel Gpr39 Agonists: Correlation Of Binding Affinity Using Label-Free Back-Scattering Interferometry With Potency In Functional Assays|
Daniel Brown (1), Niklas Larsson (2), Ola Fjellström (3), Anders Johansson (3), Sara Lundqvist (2), Johan Brengdahl (2), and Richard J. Isaacs (1)
We describe the application of back-scattering interferometry (BSI) to the characterization of small molecule ligand binding to human GPR39 (a GPCR targeted for type-2 diabetes therapy) overexpressed in crude membrane fractions in free solution, including how BSI-derived affinity and functional assay-derived potency correlate for compounds of varying scaffolds
|GC-MS/MS ANALYSIS OF BENZODIAZEPINES USING ANALYTE PROTECTANTS|
Jeremy Matthews, Alex Chen, Flavio Bedini
Purpose: Assess the feasibility of using analyte protectants to improve the analysis of benzodiazepines.
|Targeted cancer therapy based on blocking the expression of genes and small doses of oxaliplatin.|
Bavykin A.S.1, Korotaeva A.A.1, Poyarkov S.V.2, Syrtsev A.V.1, Karpukhin A.V.1
The major drawbacks of the prescribed chemotherapy, are still remain the significant side effects and drug - resistance. Even targeted chemotherapy by means of specific antibodies do not always help to solve these complications. Our purpose was to identify potential biological targets associated with the development of drug resistance and to develop a specific method of suppressing the viability of cancer cells exposed to low doses of standard chemotherapy.
|Inverted Y Approach to Lumbosacral region - Analysis of 525 cases over 10 years|
Dr Krishna Kumar and Dr Renjith Kumar
Traditional approach to lumosacral region utilizes midline incision, which often requires long incision to get sufficient exposure. We describe our experience with inverted Y approach to lumbosacral junction.
|Evaluation of an automated SPE method for samples derived from capillary microsampling|
Paul-Gerhard Lassahn1, Petra Lombardi1, Winfried Wagner-Redeker1, Marie-Claude Robaudi-Fraschini2, Reto Bolliger3, Guenter Boehm3
In this poster we describe an automated SPE procedure using small, single use cartridges in a modified PAL System liquid handler for the analysis of samples derived from capillary microsampling. Results are compared to results obtained from identical samples processed manually by protein precipitation.
|LC/MS/MS Quantitation of Eicosapentaenoic Acid in Rat Plasma|
Rachel Sun, Jordan Nally, Tim Shoaf
Eicosapentaenoic acid (EPA) is an omega-3 fatty acid, which has been documented to be important in biochemical and physiological processes including inflammatory response, blood clotting and the immune system. Eicosapentaenoic acid (EPA) appears in different forms in the blood including triglyceride, ethyl ester, or free acid. In this work we presented an LC/MS/MS method to quantitate the total eicosapentaenoic acid in rat plasma with a 96-well plate format.
|Comparison of Dissociated Phoria Measuring Methods. Repeatability and Reliability|
Ane Murueta-Goyena Larrañaga
The aim of this study is to determine the reliability and compare reproducibility of different dissociated phoria measure tests.
|Secondary Prevention of Stroke: The role of the General Practitioner|
This study aims to review the literature to further elucidate the potential impact of primary care physicians in reducing the burden of stroke.
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