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Lucentis Effective for Proliferative Diabetic Retinopathy
NIH-funded clinical trial marks first major advance in therapy in 40 years.
Blocking the Transmission Of Malaria Parasites
Vaccine candidate administered for the first time in humans in a phase I clinical trial led by Oxford University’s Jenner Institute, with partners Imaxio and GSK.
First Therapy Appearing to Reverse Decline in Parkinson’s
An FDA-approved drug for leukemia improved cognition, motor skills and non-motor function in patients with Parkinson’s disease and Lewy body dementia in a small clinical trial, say researchers at Georgetown University Medical Center (GUMC).
Gene Therapy Staves Off Blindness from Retinitis Pigmentosa in Canine Model
NIH-funded study suggests therapeutic window may extend to later-stage disease.
Treatment for Rare Bleeding Disorder is Effective
Researchers in Manchester have demonstrated for the first time the relative safety and effectiveness of treatment, eltrombopag, in children with persistent or chronic immune thrombocytopenia (ITP), as part of an international duo of studies.
HIV Vaccine Human Trials Begin
Baltimore-based Institute has begun enrolling volunteers for initial phase 1 clinical trials.
New Therapy Reduces Symptoms of Inherited Enzyme Deficiency
A phase three clinical trial of a new enzyme replacement medication, sebelipase alfa, showed a reduction in multiple disease-related symptoms in children and adults with lysosomal acid lipase deficiency, an inherited enzyme deficiency that can result in scarring of the liver and high cholesterol.
Fixing Holes in the Heart Without Invasive Surgery
UV-light enabled catheter is a medical device which represents a major shift in how cardiac defects are repaired.
Atriva Therapeutics GmbH Develops Innovative Flu Drug
Highly effective against seasonal and pandemic influenza.
Study Removes Cancer Doubt for Multiple Sclerosis Drug
Researchers from Queen Mary University of London are calling on the medical community to reconsider developing a known drug to treat people with relapsing Multiple sclerosis after new evidence shows it does not increase the risk of cancer as previously thought.
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Clinical Investigation
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Clinical Investigation is dedicated to systematic coverage of the methodology, progress and outcomes of clinical trials. As a peer-reviewed, monthly publication Clinical Investigation provides a forum for the rapid publication of original research and critically reviews the latest developments in medical research, from Phase 1 trials through to post-marketing studies and pharmacoeconomic research.

The fully-loaded costs involved in bringing a new medicine to market can be as high as $1.3 billion dollars, and much of this cost is incurred during clinical evaluation. Although dozens of new therapeutic entities enter clinical use each year, only one of every 10,000 potential medicines survives the development and approval process. The process of clinical development is therefore highly expensive, involved and complex, with huge demands placed on investigators to deliver robust, reproducible data and to meet the exacting requirements of regulatory authorities.

Clinical Investigation assimilates the wealth of information resulting from the clinical development of new medicines into concise yet comprehensive formats. The journal addresses contemporary issues in clinical drug development and methodology, and also provides a platform for the rapid publication of new drug data from human studies. Coverage spans all therapeutic areas and relates to conventional small-molecule drugs as well as biotech-derived therapeutic entities, including vaccines, monoclonal antibodies, antisense, cell and gene therapies and recombinant proteins. The journal publishes review articles, original papers, perspectives, commentaries, meeting reports, news, views and more.

Topics include:

    * Clinical study design and methodology
    * Overviews of the clinical progress of new drugs or drug classes
    * Clinical progress for specific diseases or therapeutic areas
    * Findings in Phase I to IV clinical studies
    * Healthcare outcomes and pharmacoeconomics
    * Patient stratification and individualized therapies
    * Commentary on trials in progress
    * Drug safety issues and adverse event monitoring
    * Biomarkers in clinical trials
    * Regulatory issues
    * Clinical trial data management and statistics

Further Information

Related Content

New Journal Dedicated to Clinical Investigation
In recognition of the methodology, progress and outcome of clinical trials, Future Science has announced the launch of Clinical Investigation. The journal is the latest addition to the Future Science’s collection of titles addressing those areas that most impact our daily lives.
Friday, December 17, 2010

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