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Immunotherapy Agent Benefits Patients with Drug-Resistant Multiple Myeloma in First Human Trial
Daratumumab proved generally safe in patients, even at the highest doses.
NIH Study Shows No Benefit of Omega-3 Supplements for Cognitive Decline
Research was published in the Journal of the American Medical Association.
NIH Launches Human RSV Study
Study aims to understand infection in healthy adults to aid development of RSV medicines, vaccines.
Computerized Flexible Needles Prove Themselves in Biological Tissue
The advantage of the system is that you can avoid obstacles with the needles or critical tissues and that the system during the insertion of the needle in real time can adjust the path if, for example, the tissue deforms.
DARWIN 2 24-week Monotherapy Data in RA Confirm Previous Results
Safety profile in DARWIN 2 consistent with previous filgotinib RA studies.
Researchers Publish Landmark “Basket Study”
Researchers from Memorial Sloan Kettering Cancer Center (MSK) have announced results from the first published basket study, a new form of clinical trial design that explores responses to drugs based on the specific mutations in patients’ tumors rather than where their cancer originated.
Agricultural Intervention Improves HIV Outcomes
A multifaceted farming intervention can reduce food insecurity while improving HIV outcomes in patients in Kenya, according to a randomized, controlled trial led by researchers at UC San Francisco.
Overdose of Vitamin D in Teenagers May Lead to Increased Cholesterol Levels
Dosing obese teens with vitamin D shows no benefits for their heart health or diabetes risk, and could have the unintended consequences of increasing cholesterol and fat-storing triglycerides. These are the latest findings in a series of Mayo Clinic studies in childhood obesity.
Phase 2 Trials Underway for New Single Dose Malaria Treatment
The new drug, which prevents the malaria parasite from reproducing and spreading, is now undergoing Phase II clinical trials in humans.
Promising Drug for Parkinson's Disease
A drug which has already been in use for decades to treat liver disease could be an effective treatment to slow down progression of Parkinson’s disease, scientists from the University of Sheffield have discovered.
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Clinical Investigation
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Clinical Investigation is dedicated to systematic coverage of the methodology, progress and outcomes of clinical trials. As a peer-reviewed, monthly publication Clinical Investigation provides a forum for the rapid publication of original research and critically reviews the latest developments in medical research, from Phase 1 trials through to post-marketing studies and pharmacoeconomic research.

The fully-loaded costs involved in bringing a new medicine to market can be as high as $1.3 billion dollars, and much of this cost is incurred during clinical evaluation. Although dozens of new therapeutic entities enter clinical use each year, only one of every 10,000 potential medicines survives the development and approval process. The process of clinical development is therefore highly expensive, involved and complex, with huge demands placed on investigators to deliver robust, reproducible data and to meet the exacting requirements of regulatory authorities.

Clinical Investigation assimilates the wealth of information resulting from the clinical development of new medicines into concise yet comprehensive formats. The journal addresses contemporary issues in clinical drug development and methodology, and also provides a platform for the rapid publication of new drug data from human studies. Coverage spans all therapeutic areas and relates to conventional small-molecule drugs as well as biotech-derived therapeutic entities, including vaccines, monoclonal antibodies, antisense, cell and gene therapies and recombinant proteins. The journal publishes review articles, original papers, perspectives, commentaries, meeting reports, news, views and more.

Topics include:

    * Clinical study design and methodology
    * Overviews of the clinical progress of new drugs or drug classes
    * Clinical progress for specific diseases or therapeutic areas
    * Findings in Phase I to IV clinical studies
    * Healthcare outcomes and pharmacoeconomics
    * Patient stratification and individualized therapies
    * Commentary on trials in progress
    * Drug safety issues and adverse event monitoring
    * Biomarkers in clinical trials
    * Regulatory issues
    * Clinical trial data management and statistics

Further Information

Related Content

New Journal Dedicated to Clinical Investigation
In recognition of the methodology, progress and outcome of clinical trials, Future Science has announced the launch of Clinical Investigation. The journal is the latest addition to the Future Science’s collection of titles addressing those areas that most impact our daily lives.
Friday, December 17, 2010
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